Prime Medicine (PRME) EBIT (2021 - 2026)

Prime Medicine posted quarterly EBIT of -$50.7 million for Q1 2026, up 3.32% year-on-year from -$49.0 million in Q1 2025, and down 4.21% on a QoQ basis from -$48.6 million in Q4 2025.

Prime Medicine (PRME) has 6 years of EBIT data on file, last reported at -$50.7 million in Q1 2026.

  • For the quarter ending Q1 2026, EBIT rose 3.32% year-over-year to -$50.7 million; the trailing twelve-month figure through Mar 2026 stood at -$206.6 million (changed 0.05% YoY), and the FY2025 full-year result was -$208.4 million, down 2.91% from the prior year.
  • EBIT for Q1 2026 stood at -$50.7 million, down from -$48.6 million in the prior quarter.
  • Across five years, EBIT topped out at -$19.9 million in Q1 2022 and bottomed at -$68.0 million in Q4 2023.
  • The 5-year median for EBIT is -$48.6 million (2025), against an average of -$46.0 million.
  • Peak annual rise in EBIT reached 35.6% in 2022, while the deepest fall reached 203.59% in 2022.
  • A 5-year view of EBIT shows it stood at -$38.7 million in 2022, then tumbled by 75.89% to -$68.0 million in 2023, then jumped by 35.01% to -$44.2 million in 2024, then slipped by 9.92% to -$48.6 million in 2025, then declined by 4.21% to -$50.7 million in 2026.
  • The last three EBIT figures came in at -$50.7 million (Q1 2026), -$48.6 million (Q4 2025), and -$54.0 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBIT (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - -2.97 Mn
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - -
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn -19.70 Mn
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - -15.76 Mn
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 1.14 Bn
7 Evaxion A 62.56 Bn 62.54 Bn - -3.82 Mn
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn 642.90 Mn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 268.64 Mn
10 Prime Medicine 601.24 Mn 601.24 Mn - -50.65 Mn

Historic Data

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DateValue
Mar 31, 2026 -50.65 Mn
Dec 31, 2025 -48.61 Mn
Sep 30, 2025 -53.97 Mn
Jun 30, 2025 -53.38 Mn
Mar 31, 2025 -52.39 Mn
Dec 31, 2024 -44.22 Mn
Sep 30, 2024 -54.23 Mn
Jun 30, 2024 -55.67 Mn
Mar 31, 2024 -48.34 Mn
Dec 31, 2023 -68.04 Mn
Sep 30, 2023 -51.46 Mn
Jun 30, 2023 -45.26 Mn
Mar 31, 2023 -40.03 Mn
Dec 31, 2022 -38.69 Mn
Sep 30, 2022 -31.66 Mn
Jun 30, 2022 -26.31 Mn
Mar 31, 2022 -19.90 Mn
Dec 31, 2021 -60.08 Mn
Sep 30, 2021 -10.43 Mn