Prelude Therapeutics (PRLD) Return on Capital Employed (2020 - 2026)

Prelude Therapeutics' (PRLD) quarterly Return on Capital Employed came in at 94.79% in Q1 2026, up 620.0% year-on-year from 13.17% in Q1 2025, and up 41.04% quarter-over-quarter from 160.77% in Q4 2025.

Prelude Therapeutics (PRLD) Return on Capital Employed (2020 - 2026) Analysis & Trends

Prelude Therapeutics has disclosed Return on Capital Employed across 7 years of filings, most recently posting 94.79% for Q1 2026.

  • Return on Capital Employed for Q1 2026 came in at 94.79%, up 620.0% year-over-year; the trailing twelve-month figure through Mar 2026 was 94.79% (up 620.0% YoY), and the FY2025 annual result was 99.19%, down 2966.0% from the prior year.
  • Return on Capital Employed came in at 94.79% for Q1 2026 at Prelude Therapeutics, up from 160.77% in the prior quarter.
  • In the past five years, Return on Capital Employed ranged from a high of 44.09% in Q1 2022 to a low of 160.77% in Q4 2025.
  • The 5-year median for Return on Capital Employed is 64.49% (2023), against an average of 78.74%.
  • Across the five-year window, Return on Capital Employed soared 831 bps in 2024 and plunged 7384 bps in 2025, its largest moves.
  • Prelude Therapeutics' Return on Capital Employed stood at 58.91% in 2022, then increased by 9 bps to 53.71% in 2023, then sank by 62 bps to 86.93% in 2024, then tumbled by 85 bps to 160.77% in 2025, then soared by 41 bps to 94.79% in 2026.
  • The last three Return on Capital Employed figures came in at 94.79% (Q1 2026), 160.77% (Q4 2025), and 139.7% (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) ROCE (Qtr)
1 Alterity Therapeutics 723,416.35 Bn 723,416.32 Bn - -
2 Belite Bio 57,340.00 Bn 57,340.00 Bn - -
3 Quantum Biopharma 19,125.08 Bn 19,125.08 Bn - 450.31%
4 Legend Biotech 3,262.00 Bn 3,261.71 Bn 242.10 Mn 51.73%
5 Akari Therapeutics 1,789.67 Bn 1,789.67 Bn - -107.40%
6 Evaxion A 1,480.39 Bn 1,480.37 Bn - -
7 Psyence Biomedical 241.78 Bn 241.78 Bn - -
8 Vertex Pharmaceuticals 113.54 Bn 106.29 Bn 2.59 Bn 21.10%
9 Abivax 94.26 Bn 94.26 Bn - -50.43%
10 Prelude Therapeutics 314.40 Mn 169.80 Mn - -94.79%

Historic Data

Download Data
DateValue
Mar 31, 2026 -94.79%
Dec 31, 2025 -160.77%
Sep 30, 2025 -139.70%
Jun 30, 2025 -125.96%
Mar 31, 2025 -100.99%
Dec 31, 2024 -86.93%
Sep 30, 2024 -75.99%
Jun 30, 2024 -66.99%
Mar 31, 2024 -56.18%
Dec 31, 2023 -53.71%
Sep 30, 2023 -50.77%
Jun 30, 2023 -55.87%
Mar 31, 2023 -64.49%
Dec 31, 2022 -58.91%
Sep 30, 2022 -53.75%
Jun 30, 2022 -48.65%
Mar 31, 2022 -44.09%
Dec 31, 2021 -38.04%
Sep 30, 2021 -31.23%
Jun 30, 2021 -25.35%