Prelude Therapeutics Inc (PRLD) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

76,035,374Shares Outstanding

21,252,929Shares held by institutions

$44,843,680Value of institutional holdings

36.43%Institutional ownership %

6.36%Shares Changed QoQ

46No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Prelude Therapeutics Inc (NASDAQ:PRLD) currently has 46 active institutional owners and shareholders as of today (December 2025), that have filed 13F forms with the Securities Exchange Commission (SEC).

The percentage of Prelude Therapeutics owned by institutions changed from 35.7% in September 2025 to 36.4% in December 2025, marking a slight up trend.
Quarterly data indicates a 6.36% shift in institutional share volume, and the annual owner count reflects a decrease of 24.59%.
The latest 13F cycle for Prelude Therapeutics reveals that of 46 total investors, 24 funds grew their exposure, whereas 13 reduced theirs and 9 made no changes.
Collectively, institutional investors increased their stake in Prelude Therapeutics to 27.70Mn shares as of December 2025, a change that is up by 1.66Mn shares quarter on quarter and down 4.30Mn shares year over year.
The top institutional stake in Prelude Therapeutics as of December 31, 2025 belongs to ORBIMED ADVISORS LLC, which owns 10.91Mn shares, or 14.35% of the company.
Among the most significant buyers of Prelude Therapeutics during December 2025 were Kynam Capital Management, LP (788.87K), TWO SIGMA INVESTMENTS, LP (636.46K), VANGUARD GROUP INC (421.13K), MARSHALL WACE, LLP (273.88K), SUSQUEHANNA INTERNATIONAL GROUP, LLP (135.91K).
Leading sellers of Prelude Therapeutics stock in December 2025 included MILLENNIUM MANAGEMENT LLC (996.05K), RENAISSANCE TECHNOLOGIES LLC (272.70K), PRUDENTIAL FINANCIAL INC (10.32K), CITIGROUP INC (5.97K), ROYAL BANK OF CANADA (5.97K).
The top 10 institutional holders of Prelude Therapeutics for the quarter ending December 2025 included ORBIMED ADVISORS LLC (10.91Mn), BAKER BROS. ADVISORS LP (10.12Mn), VANGUARD GROUP INC (1.41Mn), Kynam Capital Management, LP (788.87K), TWO SIGMA INVESTMENTS, LP (788.70K), ACADIAN ASSET MANAGEMENT LLC (535.70K), MORGAN STANLEY (334.92K), MARSHALL WACE, LLP (273.88K), GEODE CAPITAL MANAGEMENT, LLC (272.89K), RENAISSANCE TECHNOLOGIES LLC (271.30K).

46 Institutional Holders

21,252,929 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
ORBIMED ADVISORS LLC	31 Dec, 2025	10,909,256	0	0.00%	$31,636,842.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	10,123,824	0	0.00%	$29,359,090.00
VANGUARD GROUP INC	31 Dec, 2025	1,413,986	421,132	42.42%	$4,100,559.00
Kynam Capital Management, LP	31 Dec, 2025	788,867	788,867	0.00%	$2,287,714.00
TWO SIGMA INVESTMENTS, LP	31 Dec, 2025	788,695	636,462	418.08%	$2,287,216.00
ACADIAN ASSET MANAGEMENT LLC	31 Dec, 2025	535,703	-4,862	-0.90%	$1,551.00
MORGAN STANLEY	31 Dec, 2025	334,916	50,713	17.84%	$971,257.00
MARSHALL WACE, LLP	31 Dec, 2025	273,883	273,883	0.00%	$794,260.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	272,886	55,318	25.43%	$791,502.00
RENAISSANCE TECHNOLOGIES LLC	31 Dec, 2025	271,300	-272,700	-50.13%	$786,770.00
BlackRock, Inc.	31 Dec, 2025	266,280	1,307	0.49%	$772,212.00
TWO SIGMA ADVISERS, LP	31 Dec, 2025	237,300	14,600	6.56%	$688,170.00
TD ASSET MANAGEMENT INC	31 Dec, 2025	160,652	0	0.00%	$465,891.00
MILLENNIUM MANAGEMENT LLC	31 Dec, 2025	150,997	-996,047	-86.84%	$437,891.00
SUSQUEHANNA INTERNATIONAL GROUP, LLP	31 Dec, 2025	135,909	135,909	0.00%	$394,136.00
STATE STREET CORP	31 Dec, 2025	127,292	29,700	30.43%	$369,147.00
SPHERA FUNDS MANAGEMENT LTD.	31 Dec, 2025	122,752	122,752	0.00%	$355,981.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	117,477	38,150	48.09%	$340,683.00
JANE STREET GROUP, LLC	31 Dec, 2025	111,040	76,218	218.88%	$322,016.00
OMERS ADMINISTRATION Corp	31 Dec, 2025	73,000	73,000	0.00%	$211,700.00

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