Prelude Therapeutics Inc (PRLD) Institutional Ownership

Institutions by Trading Activity

75,865,385Shares Outstanding

4,375Shares held by institutions

$9,494Value of institutional holdings

1.88%Institutional ownership %

41.92%Shares Changed QoQ

6No. of institutional investors

Recent 13F filings as of December 2025 show that 6 institutional investors hold a position in Prelude Therapeutics Inc (NASDAQ:PRLD).

Prelude Therapeutics saw its institutional ownership percentage fell to 1.9% in December 2025 from 35.8% in September 2025.
On a quarter-over-quarter basis, institutional holdings shifted by 41.92%, with a year-over-year a decrease of 90.16% in the count of filers.
During the quarter, 2 institutions bought more Prelude Therapeutics shares, 2 sold shares, and 2 of the 6 total investors held their position steady.
Collectively, institutional investors increased their stake in Prelude Therapeutics to 1.42Mn shares as of December 2025, a change that is up by 420.29K shares quarter on quarter and down 30.57Mn shares year over year.
The top institutional stake in Prelude Therapeutics as of December 31, 2025 belongs to VANGUARD GROUP INC, which owns 1.41Mn shares, or 1.86% of the company.
Among the most significant buyers of Prelude Therapeutics during December 2025 were VANGUARD GROUP INC (421.13K), CALDWELL SUTTER CAPITAL, INC. (2.00K).
Leading sellers of Prelude Therapeutics stock in December 2025 included UBS Group AG (2.31K), CWM, LLC (527).
The top 6 institutional holders of Prelude Therapeutics for the quarter ending December 2025 included VANGUARD GROUP INC (1.41Mn), SBI Securities Co., Ltd. (2.74K), CALDWELL SUTTER CAPITAL, INC. (2.00K), UBS Group AG (1.86K), NISA INVESTMENT ADVISORS, LLC (1.63K), CWM, LLC (692).

4,375 Total Shares Held

Rows:

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
ORBIMED ADVISORS LLC	30 Sep, 2025	10,909,256	0	0.00%	$15,709,329.00
BAKER BROS. ADVISORS LP	30 Sep, 2025	10,123,824	0	0.00%	$14,578,307.00
MILLENNIUM MANAGEMENT LLC	30 Sep, 2025	1,147,044	898,621	361.73%	$1,651,743.00
VANGUARD GROUP INC	30 Sep, 2025	992,854	60,284	6.46%	$1,429,710.00
PRICE T ROWE ASSOCIATES INC /MD/	30 Sep, 2025	876,338	-51,270	-5.53%	$1,262.00
RENAISSANCE TECHNOLOGIES LLC	30 Sep, 2025	544,000	-37,800	-6.50%	$783,360.00
ACADIAN ASSET MANAGEMENT LLC	30 Sep, 2025	540,565	0	0.00%	$777.00
MORGAN STANLEY	30 Sep, 2025	284,203	-179	-0.06%	$409,252.00
BlackRock, Inc.	30 Sep, 2025	264,973	-167,586	-38.74%	$381,562.00
TWO SIGMA ADVISERS, LP	30 Sep, 2025	222,700	-2,300	-1.02%	$320,688.00
GEODE CAPITAL MANAGEMENT, LLC	30 Sep, 2025	217,568	0	0.00%	$313,366.00
TD ASSET MANAGEMENT INC	30 Sep, 2025	160,652	0	0.00%	$231,339.00
TWO SIGMA INVESTMENTS, LP	30 Sep, 2025	152,233	-2,744	-1.77%	$219,216.00
Shay Capital LLC	30 Sep, 2025	100,000	25,000	33.33%	$144,000.00
STATE STREET CORP	30 Sep, 2025	97,592	0	0.00%	$140,532.00
GOLDMAN SACHS GROUP INC	30 Sep, 2025	79,327	-69,851	-46.82%	$114,231.00
GSA CAPITAL PARTNERS LLP	30 Sep, 2025	75,161	3,783	5.30%	$108.00
MANUFACTURERS LIFE INSURANCE COMPANY, THE	30 Sep, 2025	69,252	0	0.00%	$99,723.00
BRIDGEWAY CAPITAL MANAGEMENT, LLC	30 Sep, 2025	53,500	-35,000	-39.55%	$77,040.00
NORTHERN TRUST CORP	30 Sep, 2025	36,421	-1,706	-4.47%	$52,446.00

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