Prelude Therapeutics (PRLD) Operating Income (2019 - 2026)

Prelude Therapeutics' (PRLD) quarterly Operating Income came in at -$14.2 million in Q1 2026, up 59.03% year-on-year from -$8.9 million in Q1 2025, and up 18.28% quarter-over-quarter from -$17.3 million in Q4 2025.

Prelude Therapeutics (PRLD) Operating Income (2019 - 2026) Analysis & Trends

Prelude Therapeutics has disclosed Operating Income across 8 years of filings, most recently posting -$14.2 million for Q1 2026.

  • Operating Income for Q1 2026 came in at -$14.2 million, up 59.03% year-over-year; the trailing twelve-month figure through Mar 2026 was -$84.1 million (up 39.89% YoY), and the FY2025 annual result was -$104.6 million, up 25.16% from the prior year.
  • Operating Income came in at -$14.2 million for Q1 2026 at Prelude Therapeutics, up from -$17.3 million in the prior quarter.
  • In the past five years, Operating Income ranged from a high of -$14.2 million in Q1 2026 to a low of -$37.4 million in Q4 2023.
  • The 5-year median for Operating Income is -$32.4 million (2023), against an average of -$30.3 million.
  • Across the five-year window, Operating Income plunged 37.88% in 2022 and jumped 59.03% in 2026, its largest moves.
  • Prelude Therapeutics' Operating Income stood at -$33.4 million in 2022, then slipped by 11.96% to -$37.4 million in 2023, then increased by 9.49% to -$33.8 million in 2024, then soared by 48.72% to -$17.3 million in 2025, then grew by 18.28% to -$14.2 million in 2026.
  • The last three Operating Income figures came in at -$14.2 million (Q1 2026), -$17.3 million (Q4 2025), and -$20.4 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Op. Inc (Qtr)
1 Alterity Therapeutics 723,416.35 Bn 723,416.32 Bn - -
2 Belite Bio 57,340.00 Bn 57,340.00 Bn - -32.68 Mn
3 Quantum Biopharma 19,125.08 Bn 19,125.08 Bn - -2.97 Mn
4 Legend Biotech 3,262.00 Bn 3,261.71 Bn 242.10 Mn -19.70 Mn
5 Akari Therapeutics 1,789.67 Bn 1,789.67 Bn - -15.76 Mn
6 Evaxion A 1,480.39 Bn 1,480.37 Bn - -3.82 Mn
7 Psyence Biomedical 241.78 Bn 241.78 Bn - -
8 Vertex Pharmaceuticals 113.54 Bn 106.29 Bn 2.59 Bn 1.14 Bn
9 Abivax 94.26 Bn 94.26 Bn - -65.83 Mn
10 Prelude Therapeutics 314.40 Mn 169.80 Mn - -14.18 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -14.18 Mn
Dec 31, 2025 -17.35 Mn
Sep 30, 2025 -20.42 Mn
Jun 30, 2025 -32.19 Mn
Mar 31, 2025 -34.61 Mn
Dec 31, 2024 -33.83 Mn
Sep 30, 2024 -34.38 Mn
Jun 30, 2024 -37.16 Mn
Mar 31, 2024 -34.34 Mn
Dec 31, 2023 -37.38 Mn
Sep 30, 2023 -33.39 Mn
Jun 30, 2023 -32.40 Mn
Mar 31, 2023 -29.12 Mn
Dec 31, 2022 -33.39 Mn
Sep 30, 2022 -30.41 Mn
Jun 30, 2022 -29.46 Mn
Mar 31, 2022 -30.29 Mn
Dec 31, 2021 -33.01 Mn
Sep 30, 2021 -30.84 Mn
Jun 30, 2021 -27.92 Mn