Prelude Therapeutics PRLD
NASDAQ PRLD
$5.48 +0.23 (+4.38%)
As of: Sep 4, 2026 · 2:25 PM EDT

Prelude Therapeutics (PRLD) Operating Income (2019 - 2026)

Prelude Therapeutics (PRLD) posted Operating Income of -$14.2 million for Q1 2026, up 18.28% sequentially from -$17.3 million in Q4 2025, and up 59.03% YoY from -$8.9 million in Q1 2025.

Analysis

Prelude Therapeutics (PRLD) Operating Income (2019 - 2026) Analysis & Trends

Prelude Therapeutics has reported Operating Income for 8 years, with the latest figure at -$14.2 million in Q1 2026.

  • Quarterly Operating Income rose 59.03% year-over-year to -$14.2 million in Q1 2026, while the trailing twelve-month figure through Mar 2026 was -$84.1 million (up 39.89% YoY) and the FY2025 annual result came in at -$104.6 million, up 25.16% from the prior year.
  • Operating Income advanced to -$14.2 million in Q1 2026 per PRLD's latest filing, from -$17.3 million in the prior quarter.
  • Over five years, Operating Income peaked at -$14.2 million in Q1 2026 and troughed at -$37.4 million in Q4 2023.
  • A 5-year average of -$30.3 million and a median of -$32.4 million in 2023 frame the typical range for Operating Income.
  • The sharpest annual moves came in 2022 and 2026: Operating Income plunged 37.88% in 2022, then soared 59.03% in 2026.
  • Over 5 years, Operating Income stood at -$33.4 million in 2022, then declined by 11.96% to -$37.4 million in 2023, then gained by 9.49% to -$33.8 million in 2024, then surged by 48.72% to -$17.3 million in 2025, then rose by 18.28% to -$14.2 million in 2026.
  • According to Business Quant data, Operating Income over the past three periods registered -$14.2 million, -$17.3 million, and -$20.4 million for Q1 2026, Q4 2025, and Q3 2025 respectively.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Op. Inc (Qtr)
1 Vertex Pharmaceuticals 138.87 Bn 131.01 Bn 2.84 Bn 1.25 Bn
2 Regeneron Pharmaceuticals 85.57 Bn 77.57 Bn 3.93 Bn 1.29 Bn
3 Argenx Se 63.51 Bn 58.32 Bn 1.37 Bn 493.00 Mn
4 Moderna 58.19 Bn 53.05 Bn 52.00 Mn -815.00 Mn
5 Revolution Medicines 44.07 Bn 44.07 Bn - -505.13 Mn
6 BeOne Medicines 39.99 Bn 34.89 Bn 1.53 Bn 325.05 Mn
7 Alnylam Pharmaceuticals 35.38 Bn 32.07 Bn 992.69 Mn 231.44 Mn
8 Royalty Pharma 28.42 Bn 27.58 Bn - 133.12 Mn
9 Insmed 27.41 Bn 26.25 Bn 358.27 Mn -1.55 Mn
10 Prelude Therapeutics 539.17 Mn 258.54 Mn - -15.45 Mn
Historic Data

Historic Data

Download Data
DateValue
Jun 30, 2026 -15.45 Mn
Mar 31, 2026 -14.18 Mn
Dec 31, 2025 -17.35 Mn
Sep 30, 2025 -20.42 Mn
Jun 30, 2025 -32.19 Mn
Mar 31, 2025 -34.61 Mn
Dec 31, 2024 -33.83 Mn
Sep 30, 2024 -34.38 Mn
Jun 30, 2024 -37.16 Mn
Mar 31, 2024 -34.34 Mn
Dec 31, 2023 -37.38 Mn
Sep 30, 2023 -33.39 Mn
Jun 30, 2023 -32.40 Mn
Mar 31, 2023 -29.12 Mn
Dec 31, 2022 -33.39 Mn
Sep 30, 2022 -30.41 Mn
Jun 30, 2022 -29.46 Mn
Mar 31, 2022 -30.29 Mn
Dec 31, 2021 -33.01 Mn
Sep 30, 2021 -30.84 Mn