Prelude Therapeutics (PRLD) EBITDA (2019 - 2026)

Prelude Therapeutics' (PRLD) quarterly EBITDA came in at -$10.4 million in Q1 2026, up 67.5% year-on-year from -$6.2 million in Q1 2025, and up 36.58% quarter-over-quarter from -$16.5 million in Q4 2025.

Prelude Therapeutics (PRLD) EBITDA (2019 - 2026) Analysis & Trends

Prelude Therapeutics has disclosed EBITDA across 8 years of filings, most recently posting -$10.4 million for Q1 2026.

  • EBITDA for Q1 2026 came in at -$10.4 million, up 67.5% year-over-year; the trailing twelve-month figure through Mar 2026 was -$77.9 million (up 38.98% YoY), and the FY2025 annual result was -$99.5 million, up 21.86% from the prior year.
  • EBITDA came in at -$10.4 million for Q1 2026 at Prelude Therapeutics, up from -$16.5 million in the prior quarter.
  • In the past five years, EBITDA ranged from a high of -$10.4 million in Q1 2026 to a low of -$34.8 million in Q2 2024.
  • The 5-year median for EBITDA is -$30.5 million (2023), against an average of -$27.9 million.
  • Across the five-year window, EBITDA slumped 45.85% in 2022 and jumped 67.5% in 2026, its largest moves.
  • Prelude Therapeutics' EBITDA stood at -$28.0 million in 2022, then declined by 15.29% to -$32.2 million in 2023, then gained by 10.49% to -$28.9 million in 2024, then soared by 43.0% to -$16.5 million in 2025, then surged by 36.58% to -$10.4 million in 2026.
  • The last three EBITDA figures came in at -$10.4 million (Q1 2026), -$16.5 million (Q4 2025), and -$19.7 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBITDA (Qtr)
1 Alterity Therapeutics 723,416.35 Bn 723,416.32 Bn - -
2 Belite Bio 57,340.00 Bn 57,340.00 Bn - -26.92 Mn
3 Quantum Biopharma 19,125.08 Bn 19,125.08 Bn - -13.63 Mn
4 Legend Biotech 3,262.00 Bn 3,261.71 Bn 242.10 Mn -19.70 Mn
5 Akari Therapeutics 1,789.67 Bn 1,789.67 Bn - -14.44 Mn
6 Evaxion A 1,480.39 Bn 1,480.37 Bn - -3.82 Mn
7 Psyence Biomedical 241.78 Bn 241.78 Bn - -752,618.00
8 Vertex Pharmaceuticals 113.54 Bn 106.29 Bn 2.59 Bn 1.14 Bn
9 Abivax 94.26 Bn 94.26 Bn - -65.83 Mn
10 Prelude Therapeutics 314.40 Mn 169.80 Mn - -10.43 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -10.43 Mn
Dec 31, 2025 -16.45 Mn
Sep 30, 2025 -19.72 Mn
Jun 30, 2025 -31.24 Mn
Mar 31, 2025 -32.11 Mn
Dec 31, 2024 -28.86 Mn
Sep 30, 2024 -31.81 Mn
Jun 30, 2024 -34.80 Mn
Mar 31, 2024 -31.89 Mn
Dec 31, 2023 -32.25 Mn
Sep 30, 2023 -30.50 Mn
Jun 30, 2023 -30.74 Mn
Mar 31, 2023 -26.42 Mn
Dec 31, 2022 -27.97 Mn
Sep 30, 2022 -30.03 Mn
Jun 30, 2022 -27.36 Mn
Mar 31, 2022 -31.07 Mn
Dec 31, 2021 -33.38 Mn
Sep 30, 2021 -30.86 Mn
Jun 30, 2021 -26.87 Mn