Puma Biotechnology (PBYI) Operating Income (2010 - 2026)
Puma Biotechnology (PBYI) posted Operating Income of -$3.8 million for Q1 2026, down 122.38% on a QoQ basis from $17.1 million in Q4 2025, and down 196.08% year-over-year from $4.0 million in Q1 2025.
Puma Biotechnology (PBYI) Operating Income (2010 - 2026) Analysis & Trends
Puma Biotechnology's Operating Income history runs 17 years deep, the most recent figure standing at -$3.8 million for Q1 2026.
- Quarterly Operating Income fell 196.08% year-over-year to -$3.8 million in Q1 2026, while the trailing twelve-month figure through Mar 2026 was $29.5 million (down 20.84% YoY) and the FY2025 annual result came in at $37.3 million, up 20.45% from the prior year.
- Operating Income was -$3.8 million for Q1 2026 at Puma Biotechnology, down from $17.1 million in the prior quarter.
- Across five years, Operating Income topped out at $22.1 million in Q3 2024 and bottomed at -$3.8 million in Q1 2026.
- A 5-year average of $7.1 million and a median of $6.6 million in 2025 frame the typical range for Operating Income.
- Annual changes were most pronounced in 2023 — Operating Income surged 684.34% — and 2026, when it slumped 196.08%.
- Puma Biotechnology's Operating Income stood at $10.0 million in 2022, then surged by 47.74% to $14.8 million in 2023, then dropped by 9.68% to $13.4 million in 2024, then increased by 27.99% to $17.1 million in 2025, then tumbled by 122.38% to -$3.8 million in 2026.
- Business Quant data shows PBYI's Operating Income at -$3.8 million in Q1 2026, $17.1 million in Q4 2025, and $9.6 million in Q3 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Op. Inc (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | -27.75 Mn |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 249.90 Mn |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | -3.72 Mn |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 1.14 Bn |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 642.90 Mn |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | -32.68 Mn |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | 493.00 Mn |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | -445.22 Mn |
| 10 | Puma Biotechnology | 407.27 Mn | 368.99 Mn | 34.39 Mn | -3.83 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -3.83 Mn |
| Dec 31, 2025 | 17.11 Mn |
| Sep 30, 2025 | 9.57 Mn |
| Jun 30, 2025 | 6.64 Mn |
| Mar 31, 2025 | 3.98 Mn |
| Dec 31, 2024 | 13.37 Mn |
| Sep 30, 2024 | 22.08 Mn |
| Jun 30, 2024 | -2.18 Mn |
| Mar 31, 2024 | -2.30 Mn |
| Dec 31, 2023 | 14.80 Mn |
| Sep 30, 2023 | 8.59 Mn |
| Jun 30, 2023 | 4.89 Mn |
| Mar 31, 2023 | 4.37 Mn |
| Dec 31, 2022 | 10.02 Mn |
| Sep 30, 2022 | 2.39 Mn |
| Jun 30, 2022 | 12.06 Mn |
| Mar 31, 2022 | -747,000.00 |
| Dec 31, 2021 | 6.83 Mn |
| Sep 30, 2021 | -8.95 Mn |
| Jun 30, 2021 | -16.63 Mn |