Orchestra BioMed Holdings (OBIO) EBITDA (2021 - 2026)

Orchestra BioMed Holdings' (OBIO) quarterly EBITDA came in at -$22.1 million in Q1 2026, down 16.67% year-on-year from -$26.5 million in Q1 2025, and down 426.86% on a QoQ basis from $6.8 million in Q4 2025.

Orchestra BioMed Holdings (OBIO) EBITDA (2021 - 2026) Analysis & Trends

Orchestra BioMed Holdings (OBIO) has 6 years of EBITDA data on file, last reported at -$22.1 million in Q1 2026.

  • On a quarterly basis, EBITDA fell 16.67% year-over-year to -$22.1 million in Q1 2026; TTM through Mar 2026 was -$55.0 million, a 20.11% increase from a year earlier, with the FY2025 full-year figure at -$51.8 million, up 19.43% from the prior year.
  • EBITDA for Q1 2026 stood at -$22.1 million, down from $6.8 million in the prior quarter.
  • Over the last five years, EBITDA for OBIO reached as high as $6.8 million in Q4 2025 and fell as low as -$22.1 million in Q1 2026.
  • Historically, EBITDA has averaged -$13.1 million across 5 years, with a median of -$14.4 million in 2024.
  • Across the five-year window, EBITDA tumbled 10577.39% in 2022 and surged 140.5% in 2025, its largest moves.
  • Year by year, EBITDA stood at -$9.8 million in 2022, then fell by 26.99% to -$12.5 million in 2023, then tumbled by 33.62% to -$16.7 million in 2024, then jumped by 140.5% to $6.8 million in 2025, then slumped by 426.86% to -$22.1 million in 2026.
  • Per Business Quant data, the three most recent EBITDA figures were -$22.1 million in Q1 2026, $6.8 million in Q4 2025, and -$20.3 million in Q3 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBITDA (Qtr)
1 Oculis Holding AG 67,072.09 Bn 67,072.09 Bn - -27.75 Mn
2 Nanobiotix 1,894.61 Bn 1,894.55 Bn - -
3 Akari Therapeutics 1,014.18 Bn 1,014.18 Bn - -15.76 Mn
4 BeOne Medicines 471.64 Bn 466.85 Bn 1.35 Bn 249.90 Mn
5 Vertex Pharmaceuticals 121.72 Bn 114.47 Bn 2.59 Bn 1.14 Bn
6 Regeneron Pharmaceuticals 68.28 Bn 59.52 Bn 3.31 Bn 642.90 Mn
7 Belite Bio 61.40 Bn 61.40 Bn - -32.68 Mn
8 Argenx Se 56.94 Bn 56.94 Bn 1.18 Bn 394.00 Mn
9 Revolution Medicines 37.37 Bn 37.37 Bn - -445.22 Mn
10 Orchestra BioMed Holdings 235.83 Mn 141.43 Mn 78,000.00 -22.08 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -22.08 Mn
Dec 31, 2025 6.75 Mn
Sep 30, 2025 -20.31 Mn
Jun 30, 2025 -19.33 Mn
Mar 31, 2025 -18.92 Mn
Dec 31, 2024 -16.68 Mn
Sep 30, 2024 -16.34 Mn
Jun 30, 2024 -16.86 Mn
Mar 31, 2024 -14.42 Mn
Dec 31, 2023 -12.48 Mn
Sep 30, 2023 -14.52 Mn
Jun 30, 2023 -12.96 Mn
Mar 31, 2023 -11.55 Mn
Dec 31, 2022 -9.83 Mn
Sep 30, 2022 -10.07 Mn
Jun 30, 2022 -7.63 Mn
Mar 31, 2022 -5.13 Mn
Dec 31, 2021 -92,045.00
Sep 30, 2021 -94,445.00
Jun 30, 2021 -96,318.00