Orchestra BioMed Holdings (OBIO) EBITDA (2021 - 2026)
Orchestra BioMed Holdings' (OBIO) quarterly EBITDA came in at -$22.1 million in Q1 2026, down 16.67% year-on-year from -$26.5 million in Q1 2025, and down 426.86% on a QoQ basis from $6.8 million in Q4 2025.
Orchestra BioMed Holdings (OBIO) EBITDA (2021 - 2026) Analysis & Trends
Orchestra BioMed Holdings (OBIO) has 6 years of EBITDA data on file, last reported at -$22.1 million in Q1 2026.
- On a quarterly basis, EBITDA fell 16.67% year-over-year to -$22.1 million in Q1 2026; TTM through Mar 2026 was -$55.0 million, a 20.11% increase from a year earlier, with the FY2025 full-year figure at -$51.8 million, up 19.43% from the prior year.
- EBITDA for Q1 2026 stood at -$22.1 million, down from $6.8 million in the prior quarter.
- Over the last five years, EBITDA for OBIO reached as high as $6.8 million in Q4 2025 and fell as low as -$22.1 million in Q1 2026.
- Historically, EBITDA has averaged -$13.1 million across 5 years, with a median of -$14.4 million in 2024.
- Across the five-year window, EBITDA tumbled 10577.39% in 2022 and surged 140.5% in 2025, its largest moves.
- Year by year, EBITDA stood at -$9.8 million in 2022, then fell by 26.99% to -$12.5 million in 2023, then tumbled by 33.62% to -$16.7 million in 2024, then jumped by 140.5% to $6.8 million in 2025, then slumped by 426.86% to -$22.1 million in 2026.
- Per Business Quant data, the three most recent EBITDA figures were -$22.1 million in Q1 2026, $6.8 million in Q4 2025, and -$20.3 million in Q3 2025.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 67,072.09 Bn | 67,072.09 Bn | - | -27.75 Mn |
| 2 | Nanobiotix | 1,894.61 Bn | 1,894.55 Bn | - | - |
| 3 | Akari Therapeutics | 1,014.18 Bn | 1,014.18 Bn | - | -15.76 Mn |
| 4 | BeOne Medicines | 471.64 Bn | 466.85 Bn | 1.35 Bn | 249.90 Mn |
| 5 | Vertex Pharmaceuticals | 121.72 Bn | 114.47 Bn | 2.59 Bn | 1.14 Bn |
| 6 | Regeneron Pharmaceuticals | 68.28 Bn | 59.52 Bn | 3.31 Bn | 642.90 Mn |
| 7 | Belite Bio | 61.40 Bn | 61.40 Bn | - | -32.68 Mn |
| 8 | Argenx Se | 56.94 Bn | 56.94 Bn | 1.18 Bn | 394.00 Mn |
| 9 | Revolution Medicines | 37.37 Bn | 37.37 Bn | - | -445.22 Mn |
| 10 | Orchestra BioMed Holdings | 235.83 Mn | 141.43 Mn | 78,000.00 | -22.08 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -22.08 Mn |
| Dec 31, 2025 | 6.75 Mn |
| Sep 30, 2025 | -20.31 Mn |
| Jun 30, 2025 | -19.33 Mn |
| Mar 31, 2025 | -18.92 Mn |
| Dec 31, 2024 | -16.68 Mn |
| Sep 30, 2024 | -16.34 Mn |
| Jun 30, 2024 | -16.86 Mn |
| Mar 31, 2024 | -14.42 Mn |
| Dec 31, 2023 | -12.48 Mn |
| Sep 30, 2023 | -14.52 Mn |
| Jun 30, 2023 | -12.96 Mn |
| Mar 31, 2023 | -11.55 Mn |
| Dec 31, 2022 | -9.83 Mn |
| Sep 30, 2022 | -10.07 Mn |
| Jun 30, 2022 | -7.63 Mn |
| Mar 31, 2022 | -5.13 Mn |
| Dec 31, 2021 | -92,045.00 |
| Sep 30, 2021 | -94,445.00 |
| Jun 30, 2021 | -96,318.00 |