Monopar Therapeutics (MNPR) Net Cash Flow (2017 - 2025)
Quarterly results put Net Cash Flow at -$65.9 million for Q4 2025, down 265.69% from a year ago — trailing twelve months through Dec 2025 was $15.9 million (down 58.7% YoY), and the annual figure for FY2025 was $15.9 million, down 58.7%.
Monopar Therapeutics has reported Net Cash Flow over the past 9 years, most recently at -$65.9 million for Q4 2025.
- Net Cash Flow reached -$65.9 million in Q4 2025 per MNPR's latest filing, down from $88.2 million in the prior quarter.
- Across five years, Net Cash Flow topped out at $88.2 million in Q3 2025 and bottomed at -$65.9 million in Q4 2025.
- Median Net Cash Flow over the past 5 years was -$1.6 million (2021), compared with a mean of $2.3 million.
- The largest annual shift saw Net Cash Flow plummeted 2814.45% in 2021 before it soared 84636.59% in 2025.
- Over 5 years, Net Cash Flow stood at -$2.0 million in 2021, then crashed by 198.16% to -$6.1 million in 2022, then surged by 128.92% to $1.8 million in 2023, then skyrocketed by 2162.54% to $39.8 million in 2024, then plummeted by 265.69% to -$65.9 million in 2025.
- Business Quant data shows Net Cash Flow for MNPR at -$65.9 million in Q4 2025, $88.2 million in Q3 2025, and -$206922.0 in Q2 2025.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Cash Flow (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,384,976.65 Bn | 1,384,976.64 Bn | - | 2.44 Mn |
| 2 | Alterity Therapeutics | 777,208.84 Bn | 777,208.81 Bn | - | - |
| 3 | Legend Biotech | 2,801.00 Bn | 2,800.10 Bn | 242.10 Mn | 625.70 Mn |
| 4 | Nanobiotix | 2,226.01 Bn | 2,225.95 Bn | - | - |
| 5 | Akari Therapeutics | 605.66 Bn | 605.66 Bn | - | -2.44 Mn |
| 6 | Vertex Pharmaceuticals | 110.17 Bn | 102.92 Bn | 2.59 Bn | 457.40 Mn |
| 7 | Regeneron Pharmaceuticals | 66.86 Bn | 58.11 Bn | 3.31 Bn | -152.20 Mn |
| 8 | Evaxion A | 65.12 Bn | 65.10 Bn | - | - |
| 9 | Alnylam Pharmaceuticals | 39.94 Bn | 36.94 Bn | 959.66 Mn | 60.68 Mn |
| 10 | Monopar Therapeutics | 466.82 Mn | 466.82 Mn | - | -65.94 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -65.94 Mn |
| Dec 31, 2025 | -65.94 Mn |
| Sep 30, 2025 | 88.18 Mn |
| Sep 30, 2025 | 88.18 Mn |
| Jun 30, 2025 | -206,922.00 |
| Jun 30, 2025 | -206,922.00 |
| Mar 31, 2025 | -6.10 Mn |
| Mar 31, 2025 | -6.10 Mn |
| Dec 31, 2024 | 39.80 Mn |
| Dec 31, 2024 | 39.80 Mn |
| Sep 30, 2024 | -104,304.00 |
| Sep 30, 2024 | -104,304.00 |
| Jun 30, 2024 | -1.69 Mn |
| Jun 30, 2024 | -1.69 Mn |
| Mar 31, 2024 | 543,151.00 |
| Mar 31, 2024 | 543,151.00 |
| Dec 31, 2023 | 1.76 Mn |
| Dec 31, 2023 | 1.76 Mn |
| Sep 30, 2023 | -1.71 Mn |
| Sep 30, 2023 | -1.71 Mn |
| Jun 30, 2023 | 1.49 Mn |
| Jun 30, 2023 | 1.49 Mn |
| Mar 31, 2023 | -2.45 Mn |
| Mar 31, 2023 | -2.45 Mn |
| Dec 31, 2022 | -6.08 Mn |
| Dec 31, 2022 | -6.08 Mn |
| Sep 30, 2022 | -2.17 Mn |
| Sep 30, 2022 | -2.17 Mn |
| Jun 30, 2022 | -1.38 Mn |
| Jun 30, 2022 | -1.38 Mn |
| Mar 31, 2022 | -2.48 Mn |
| Mar 31, 2022 | -2.48 Mn |
| Dec 31, 2021 | -2.04 Mn |
| Dec 31, 2021 | -2.04 Mn |
| Sep 30, 2021 | -1.95 Mn |
| Sep 30, 2021 | -1.95 Mn |
| Jun 30, 2021 | -1.43 Mn |
| Jun 30, 2021 | -1.43 Mn |
| Mar 31, 2021 | 8.98 Mn |
| Mar 31, 2021 | 8.98 Mn |
| Dec 31, 2020 | -1.25 Mn |
| Dec 31, 2020 | -1.25 Mn |
| Sep 30, 2020 | 5.43 Mn |
| Sep 30, 2020 | 5.43 Mn |
| Jun 30, 2020 | -49,070.00 |
| Jun 30, 2020 | -49,070.00 |
| Mar 31, 2020 | -617,526.00 |
| Mar 31, 2020 | -617,526.00 |
| Dec 31, 2019 | 8.72 Mn |
| Dec 31, 2019 | 8.72 Mn |
| Sep 30, 2019 | -626,549.00 |
| Sep 30, 2019 | -626,549.00 |
| Jun 30, 2019 | -752,057.00 |
| Jun 30, 2019 | -752,057.00 |
| Mar 31, 2019 | -1.01 Mn |
| Mar 31, 2019 | -1.01 Mn |
| Dec 31, 2018 | -725,482.00 |
| Dec 31, 2018 | -725,482.00 |
| Sep 30, 2018 | -599,563.00 |
| Sep 30, 2018 | -599,563.00 |
| Jun 30, 2018 | -752,863.00 |
| Jun 30, 2018 | -752,863.00 |
| Mar 31, 2018 | -808,849.00 |
| Mar 31, 2018 | -808,849.00 |
| Dec 31, 2017 | -806,020.00 |
| Dec 31, 2017 | -806,020.00 |
| Sep 30, 2017 | 6.31 Mn |
| Sep 30, 2017 | 6.31 Mn |
| Jun 30, 2017 | 729,912.00 |
| Jun 30, 2017 | 729,912.00 |
| Mar 31, 2017 | 678,516.00 |
| Mar 31, 2017 | 678,516.00 |