Monopar Therapeutics MNPR
NASDAQ MNPR
$117.56 -0.99 (-0.84%)
At close: Sep 4, 2026 · 4:00 PM EDT

Monopar Therapeutics (MNPR) Change in Cash (2017 - 2025)

Monopar Therapeutics (MNPR) posted Change in Cash of -$65.8 million for Q4 2025, down 174.67% sequentially from $88.2 million in Q3 2025, and down 265.45% YoY from $39.8 million in Q4 2024.

Analysis

Monopar Therapeutics (MNPR) Change in Cash (2017 - 2025) Analysis & Trends

Monopar Therapeutics has reported Change in Cash for 9 years, with the latest figure at -$65.8 million in Q4 2025.

  • Quarterly Change in Cash fell 265.45% year-over-year to -$65.8 million in Q4 2025, while the trailing twelve-month figure through Dec 2025 was $16.0 million (down 58.45% YoY) and the FY2025 annual result came in at $16.0 million, down 58.45% from the prior year.
  • Change in Cash retreated to -$65.8 million in Q4 2025 per MNPR's latest filing, from $88.2 million in the prior quarter.
  • Over five years, Change in Cash peaked at $88.2 million in Q3 2025 and troughed at -$65.8 million in Q4 2025.
  • A 5-year average of $2.3 million and a median of -$1.6 million in 2021 frame the typical range for Change in Cash.
  • The sharpest annual moves came in 2021 and 2025: Change in Cash slumped 2997.62% in 2021, then jumped 88410.54% in 2025.
  • Over 5 years, Change in Cash stood at -$2.0 million in 2021, then plunged by 200.84% to -$6.1 million in 2022, then soared by 128.56% to $1.8 million in 2023, then soared by 2173.12% to $39.8 million in 2024, then plunged by 265.45% to -$65.8 million in 2025.
  • According to Business Quant data, Change in Cash over the past three periods registered -$65.8 million, $88.2 million, and -$209473.0 for Q4 2025, Q3 2025, and Q2 2025 respectively.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Change in Cash (Qtr)
1 Vertex Pharmaceuticals 138.47 Bn 130.62 Bn 2.84 Bn 649.20 Mn
2 Regeneron Pharmaceuticals 85.18 Bn 77.19 Bn 3.93 Bn -504.60 Mn
3 Argenx Se 63.38 Bn 58.19 Bn 1.37 Bn -
4 Moderna 58.09 Bn 52.95 Bn 52.00 Mn -185.00 Mn
5 Revolution Medicines 44.33 Bn 44.33 Bn - 374.50 Mn
6 BeOne Medicines 40.02 Bn 34.92 Bn 1.53 Bn 427.25 Mn
7 Alnylam Pharmaceuticals 35.57 Bn 32.27 Bn 992.69 Mn -2.94 Mn
8 Royalty Pharma 28.45 Bn 27.61 Bn - 225.59 Mn
9 Insmed 27.48 Bn 26.32 Bn 358.27 Mn -37.42 Mn
10 Monopar Therapeutics 1.01 Bn 954.06 Mn - -
Historic Data

Historic Data

Download Data
DateValue
Dec 31, 2025 -65.84 Mn
Sep 30, 2025 88.18 Mn
Jun 30, 2025 -209,473.00
Mar 31, 2025 -6.10 Mn
Dec 31, 2024 39.80 Mn
Sep 30, 2024 -99,847.00
Jun 30, 2024 -1.69 Mn
Mar 31, 2024 541,499.00
Dec 31, 2023 1.75 Mn
Sep 30, 2023 -1.70 Mn
Jun 30, 2023 1.49 Mn
Mar 31, 2023 -2.46 Mn
Dec 31, 2022 -6.13 Mn
Sep 30, 2022 -2.15 Mn
Jun 30, 2022 -1.36 Mn
Mar 31, 2022 -2.48 Mn
Dec 31, 2021 -2.04 Mn
Sep 30, 2021 -1.95 Mn
Jun 30, 2021 -1.43 Mn
Mar 31, 2021 8.99 Mn