Monopar Therapeutics (MNPR) Change in Cash (2017 - 2025)

Monopar Therapeutics (MNPR) reported Change in Cash of -$65.8 million for Q4 2025, down 265.45% on a YoY basis from $39.8 million in Q4 2024, and down 174.67% sequentially from $88.2 million in Q3 2025.

Monopar Therapeutics (MNPR) Change in Cash (2017 - 2025) Analysis & Trends

Monopar Therapeutics (MNPR) has 9 years of Change in Cash data on file, last reported at -$65.8 million in Q4 2025.

  • For the quarter ending Q4 2025, Change in Cash fell 265.45% year-over-year to -$65.8 million; the trailing twelve-month figure through Dec 2025 stood at $16.0 million (down 58.45% YoY), and the FY2025 full-year result was $16.0 million, down 58.45% from the prior year.
  • Change in Cash retreated to -$65.8 million in Q4 2025, from $88.2 million in the prior quarter.
  • In the past five years, Change in Cash ranged from a high of $88.2 million in Q3 2025 to a low of -$65.8 million in Q4 2025.
  • A 5-year average of $2.3 million and a median of -$1.6 million in 2021 frame the typical range for Change in Cash.
  • Across the five-year window, Change in Cash plunged 2997.62% in 2021 and surged 88410.54% in 2025, its largest moves.
  • Tracing MNPR's Change in Cash over 5 years: stood at -$2.0 million in 2021, then sank by 200.84% to -$6.1 million in 2022, then soared by 128.56% to $1.8 million in 2023, then soared by 2173.12% to $39.8 million in 2024, then sank by 265.45% to -$65.8 million in 2025.
  • Business Quant data shows MNPR's Change in Cash at -$65.8 million in Q4 2025, $88.2 million in Q3 2025, and -$209473.0 in Q2 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Change in Cash (Qtr)
1 Oculis Holding AG 68,785.72 Bn 68,785.72 Bn - -22.03 Mn
2 Nanobiotix 1,895.57 Bn 1,895.51 Bn - -
3 BeOne Medicines 471.35 Bn 466.56 Bn 1.35 Bn 243.78 Mn
4 NuCana 279.75 Bn 279.75 Bn - -1.34 Mn
5 Vertex Pharmaceuticals 120.24 Bn 113.00 Bn 2.59 Bn 417.10 Mn
6 Regeneron Pharmaceuticals 67.80 Bn 59.04 Bn 3.31 Bn -153.10 Mn
7 Belite Bio 62.51 Bn 62.51 Bn - -
8 Argenx Se 57.38 Bn 57.38 Bn 1.41 Bn -
9 Revolution Medicines 37.78 Bn 37.78 Bn - 57.19 Mn
10 Monopar Therapeutics 707.36 Mn 645.53 Mn - -65.84 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 -65.84 Mn
Sep 30, 2025 88.18 Mn
Jun 30, 2025 -209,473.00
Mar 31, 2025 -6.10 Mn
Dec 31, 2024 39.80 Mn
Sep 30, 2024 -99,847.00
Jun 30, 2024 -1.69 Mn
Mar 31, 2024 541,499.00
Dec 31, 2023 1.75 Mn
Sep 30, 2023 -1.70 Mn
Jun 30, 2023 1.49 Mn
Mar 31, 2023 -2.46 Mn
Dec 31, 2022 -6.13 Mn
Sep 30, 2022 -2.15 Mn
Jun 30, 2022 -1.36 Mn
Mar 31, 2022 -2.48 Mn
Dec 31, 2021 -2.04 Mn
Sep 30, 2021 -1.95 Mn
Jun 30, 2021 -1.43 Mn
Mar 31, 2021 8.99 Mn