Monopar Therapeutics (MNPR) Change in Cash (2017 - 2025)
Monopar Therapeutics (MNPR) posted Change in Cash of -$65.8 million for Q4 2025, down 174.67% sequentially from $88.2 million in Q3 2025, and down 265.45% YoY from $39.8 million in Q4 2024.
Analysis
Monopar Therapeutics (MNPR) Change in Cash (2017 - 2025) Analysis & Trends
Monopar Therapeutics has reported Change in Cash for 9 years, with the latest figure at -$65.8 million in Q4 2025.
- Quarterly Change in Cash fell 265.45% year-over-year to -$65.8 million in Q4 2025, while the trailing twelve-month figure through Dec 2025 was $16.0 million (down 58.45% YoY) and the FY2025 annual result came in at $16.0 million, down 58.45% from the prior year.
- Change in Cash retreated to -$65.8 million in Q4 2025 per MNPR's latest filing, from $88.2 million in the prior quarter.
- Over five years, Change in Cash peaked at $88.2 million in Q3 2025 and troughed at -$65.8 million in Q4 2025.
- A 5-year average of $2.3 million and a median of -$1.6 million in 2021 frame the typical range for Change in Cash.
- The sharpest annual moves came in 2021 and 2025: Change in Cash slumped 2997.62% in 2021, then jumped 88410.54% in 2025.
- Over 5 years, Change in Cash stood at -$2.0 million in 2021, then plunged by 200.84% to -$6.1 million in 2022, then soared by 128.56% to $1.8 million in 2023, then soared by 2173.12% to $39.8 million in 2024, then plunged by 265.45% to -$65.8 million in 2025.
- According to Business Quant data, Change in Cash over the past three periods registered -$65.8 million, $88.2 million, and -$209473.0 for Q4 2025, Q3 2025, and Q2 2025 respectively.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Change in Cash (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 138.47 Bn | 130.62 Bn | 2.84 Bn | 649.20 Mn |
| 2 | Regeneron Pharmaceuticals | 85.18 Bn | 77.19 Bn | 3.93 Bn | -504.60 Mn |
| 3 | Argenx Se | 63.38 Bn | 58.19 Bn | 1.37 Bn | - |
| 4 | Moderna | 58.09 Bn | 52.95 Bn | 52.00 Mn | -185.00 Mn |
| 5 | Revolution Medicines | 44.33 Bn | 44.33 Bn | - | 374.50 Mn |
| 6 | BeOne Medicines | 40.02 Bn | 34.92 Bn | 1.53 Bn | 427.25 Mn |
| 7 | Alnylam Pharmaceuticals | 35.57 Bn | 32.27 Bn | 992.69 Mn | -2.94 Mn |
| 8 | Royalty Pharma | 28.45 Bn | 27.61 Bn | - | 225.59 Mn |
| 9 | Insmed | 27.48 Bn | 26.32 Bn | 358.27 Mn | -37.42 Mn |
| 10 | Monopar Therapeutics | 1.01 Bn | 954.06 Mn | - | - |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Dec 31, 2025 | -65.84 Mn |
| Sep 30, 2025 | 88.18 Mn |
| Jun 30, 2025 | -209,473.00 |
| Mar 31, 2025 | -6.10 Mn |
| Dec 31, 2024 | 39.80 Mn |
| Sep 30, 2024 | -99,847.00 |
| Jun 30, 2024 | -1.69 Mn |
| Mar 31, 2024 | 541,499.00 |
| Dec 31, 2023 | 1.75 Mn |
| Sep 30, 2023 | -1.70 Mn |
| Jun 30, 2023 | 1.49 Mn |
| Mar 31, 2023 | -2.46 Mn |
| Dec 31, 2022 | -6.13 Mn |
| Sep 30, 2022 | -2.15 Mn |
| Jun 30, 2022 | -1.36 Mn |
| Mar 31, 2022 | -2.48 Mn |
| Dec 31, 2021 | -2.04 Mn |
| Sep 30, 2021 | -1.95 Mn |
| Jun 30, 2021 | -1.43 Mn |
| Mar 31, 2021 | 8.99 Mn |