Karyopharm Therapeutics (KPTI) Tax Rate (2017 - 2025)
Karyopharm Therapeutics' (KPTI) quarterly Tax Rate came in at 45.79% in Q4 2025, down 4556.0% YoY from 1.03% in Q4 2024, and down 44472.77% on a QoQ basis from 0.1% in Q3 2025.
Karyopharm Therapeutics (KPTI) Tax Rate (2017 - 2025) Analysis & Trends
Karyopharm Therapeutics (KPTI) has 9 years of Tax Rate data on file, last reported at 45.79% in Q4 2025.
- Quarterly Tax Rate fell 4556.0% year-over-year to 45.79% in Q4 2025, while the trailing twelve-month figure through Dec 2025 was 1139.19% (up 106794.0% YoY) and the FY2025 annual result came in at 1139.19%, up 106794.0% from the prior year.
- Tax Rate eased to 45.79% in Q4 2025, from 0.1% in the prior quarter.
- In the past five years, Tax Rate ranged from a high of 0.28% in Q2 2024 to a low of 45.79% in Q4 2025.
- A 5-year average of 2.44% and a median of 0.2% in 2021 frame the typical range for Tax Rate.
- Annual changes were most pronounced in 2024 — Tax Rate surged 67 bps — and 2025, when it slumped 4556 bps.
- Tracing KPTI's Tax Rate over 5 years: stood at 0.31% in 2021, then grew by 16 bps to 0.26% in 2022, then surged by 149 bps to 0.13% in 2023, then sank by 286 bps to 0.24% in 2024, then sank by 19040 bps to 45.79% in 2025.
- The last three Tax Rate figures came in at 45.79% (Q4 2025), 0.1% (Q3 2025), and 0.11% (Q2 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Tax Rate (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 139.13 Bn | 131.28 Bn | 2.84 Bn | 20.98% |
| 2 | Regeneron Pharmaceuticals | 85.77 Bn | 77.77 Bn | 3.93 Bn | 15.11% |
| 3 | Argenx Se | 64.64 Bn | 59.46 Bn | 1.37 Bn | 10.91% |
| 4 | Moderna | 58.29 Bn | 53.16 Bn | 52.00 Mn | -1.96% |
| 5 | BeOne Medicines | 41.92 Bn | 36.82 Bn | 1.53 Bn | 24.15% |
| 6 | Alnylam Pharmaceuticals | 31.58 Bn | 28.28 Bn | 992.69 Mn | 7.49% |
| 7 | BioNTech SE | 28.12 Bn | 9.73 Bn | 668.28 Mn | 34.12% |
| 8 | Insmed | 27.39 Bn | 26.22 Bn | 358.27 Mn | -16.71% |
| 9 | Royalty Pharma | 27.27 Bn | 26.43 Bn | - | - |
| 10 | Karyopharm Therapeutics | 56.72 Mn | 56.72 Mn | 32.35 Mn | - |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -45.79% |
| Dec 31, 2025 | -45.79% |
| Dec 31, 2025 | -45.79% |
| Sep 30, 2025 | -0.10% |
| Sep 30, 2025 | -0.10% |
| Sep 30, 2025 | -0.10% |
| Jun 30, 2025 | -0.11% |
| Jun 30, 2025 | -0.11% |
| Jun 30, 2025 | -0.11% |
| Mar 31, 2025 | -0.15% |
| Mar 31, 2025 | -0.15% |
| Mar 31, 2025 | -0.15% |
| Dec 31, 2024 | -0.24% |
| Dec 31, 2024 | -0.24% |
| Dec 31, 2024 | -0.24% |
| Sep 30, 2024 | -0.09% |
| Sep 30, 2024 | -0.09% |
| Sep 30, 2024 | -0.09% |
| Jun 30, 2024 | 0.28% |
| Jun 30, 2024 | 0.28% |