Karyopharm Therapeutics (KPTI) Return on Sales [ROS] (2012 - 2026)
Karyopharm Therapeutics' Return on Sales [ROS] came in at -67.38% for Q2 2026, down 3.08 percentage points from -64.30% a year earlier.
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Analysis
Karyopharm Therapeutics (KPTI) Return on Sales [ROS] (2012 - 2026) Analysis & Trends
Over the trailing twelve months to Jun 30, 2026, Karyopharm Therapeutics reported Return on Sales [ROS] of -53.50%, up 30.43 percentage points year-over-year; for FY2025, it was -62.10%, up 20.14 percentage points from FY2024.
- Return on Sales [ROS] has increased in each of the last three years, with a five-year change of +96.90 percentage points (FY2020 to FY2025).
- Going back by year, Return on Sales [ROS] was -82.24% in FY2024 (+6.47 pp), -88.71% in FY2023 (+1.83 pp), -90.53% in FY2022 (-43.70 pp) and -46.84% in FY2021 (+112.16 pp).
- The Q2 2026 figure represents the lowest quarterly Return on Sales [ROS] since Q1 2025.
- Year-over-year, Return on Sales [ROS] increased in five of the last seven quarters, with an average year-over-year change of +14.48 percentage points.
- The fastest year-over-year change in Return on Sales [ROS] over five years came in Q1 2022 (a gain of 152.61 percentage points), and the weakest in Q4 2022 (a drop of 138.05 percentage points).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROS (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,076.25 Bn | 1,044.84 Bn | 19.71 Bn | 51.16% |
| 2 | Johnson & Johnson | 617.18 Bn | 535.70 Bn | 17.26 Bn | 28.21% |
| 3 | AbbVie | 464.58 Bn | 437.73 Bn | 12.70 Bn | 37.86% |
| 4 | Merck | 356.04 Bn | 310.47 Bn | 12.21 Bn | -3.52% |
| 5 | Novartis Ag | 269.07 Bn | 224.94 Bn | 11.24 Bn | 32.97% |
| 6 | Astrazeneca | 243.21 Bn | 216.77 Bn | 12.86 Bn | 20.57% |
| 7 | Amgen | 217.88 Bn | 173.28 Bn | 7.24 Bn | 34.95% |
| 8 | Gilead Sciences | 179.62 Bn | 153.74 Bn | 6.22 Bn | -133.21% |
| 9 | Pfizer | 158.45 Bn | 105.40 Bn | 10.94 Bn | 28.37% |
| 10 | Karyopharm Therapeutics | 23.15 Mn | -203.27 Mn | 32.35 Mn | -67.38% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -67.38% |
| Dec 31, 2025 | -52.36% |
| Sep 30, 2025 | -34.56% |
| Jun 30, 2025 | -64.30% |
| Mar 31, 2025 | -110.80% |
| Dec 31, 2024 | -102.42% |
| Sep 30, 2024 | -67.77% |
| Jun 30, 2024 | -65.72% |
| Mar 31, 2024 | -101.91% |
| Dec 31, 2023 | -112.03% |
| Sep 30, 2023 | -86.81% |
| Jun 30, 2023 | -78.70% |
| Mar 31, 2023 | -79.85% |
| Dec 31, 2022 | -100.86% |
| Sep 30, 2022 | -85.32% |
| Jun 30, 2022 | -108.14% |
| Mar 31, 2022 | -72.55% |
| Dec 31, 2021 | 37.19% |
| Sep 30, 2021 | -116.25% |
| Jun 30, 2021 | -217.02% |
API Access
Karyopharm Therapeutics Return on Sales [ROS] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-sales-%5Bros%5D&ticker=KPTI&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-sales-[ros]", "ticker": "KPTI", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-sales-%5Bros%5D&ticker=KPTI&period=max&api_key=YOUR_API_KEY");
const data = await res.json();