Karyopharm Therapeutics (KPTI) Return on Capital Employed [ROCE] (2013 - 2025)
Karyopharm Therapeutics' Return on Capital Employed [ROCE] was -883.74% in Q4 2025, down 742.69 percentage points from -141.05% a year earlier and down 106.46 percentage points from the prior quarter.
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Analysis
Karyopharm Therapeutics (KPTI) Return on Capital Employed [ROCE] (2013 - 2025) Analysis & Trends
For FY2025, Return on Capital Employed [ROCE] at Karyopharm Therapeutics came in at -204.49%, down 96.07 percentage points from FY2024.
- Return on Capital Employed [ROCE] has now declined for four consecutive years, with a five-year change of -134.01 percentage points (FY2020 to FY2025).
- In earlier years, Return on Capital Employed [ROCE] was -108.42% in FY2024 (-52.06 pp), -56.36% in FY2023 (-2.87 pp), -53.49% in FY2022 (-11.76 pp) and -41.74% in FY2021 (+28.75 pp).
- The Q4 2025 figure marks the lowest quarterly Return on Capital Employed [ROCE] in data going back to Q4 2013.
- Compared with a year earlier, Return on Capital Employed [ROCE] has declined for 13 straight quarters, with an average year-over-year change of -290.48 percentage points over the last eight quarters.
- The best year-over-year quarter for Return on Capital Employed [ROCE] over five years was Q3 2022 (a gain of 56.78 percentage points); the worst was Q4 2025 (a drop of 742.69 percentage points).
- Per Business Quant data, KPTI's Return on Capital Employed [ROCE] in the three quarters before Q4 2025 was -777.28% (Q3 2025), -674.55% (Q2 2025) and -213.56% (Q1 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROCE (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,137.66 Bn | 1,106.24 Bn | 19.71 Bn | 46.74% |
| 2 | Johnson & Johnson | 636.13 Bn | 556.00 Bn | 17.30 Bn | 17.52% |
| 3 | AbbVie | 505.28 Bn | 478.39 Bn | 12.70 Bn | 17.92% |
| 4 | Merck | 358.10 Bn | 312.48 Bn | 12.21 Bn | 6.28% |
| 5 | Novartis Ag | 292.59 Bn | 256.58 Bn | 11.24 Bn | 19.32% |
| 6 | Astrazeneca | 265.81 Bn | 239.50 Bn | 12.86 Bn | 16.76% |
| 7 | Amgen | 237.53 Bn | 192.93 Bn | 7.24 Bn | 16.66% |
| 8 | Gilead Sciences | 194.67 Bn | 168.86 Bn | 6.22 Bn | -5.97% |
| 9 | Pfizer | 171.17 Bn | 117.82 Bn | 10.94 Bn | 11.86% |
| 10 | Karyopharm Therapeutics | 14.83 Mn | -211.60 Mn | 32.35 Mn | - |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Dec 31, 2025 | -883.74% |
| Sep 30, 2025 | -777.28% |
| Jun 30, 2025 | -674.55% |
| Mar 31, 2025 | -213.56% |
| Dec 31, 2024 | -141.05% |
| Sep 30, 2024 | -89.83% |
| Jun 30, 2024 | -86.38% |
| Mar 31, 2024 | -84.27% |
| Dec 31, 2023 | -69.75% |
| Sep 30, 2023 | -56.62% |
| Jun 30, 2023 | -49.50% |
| Mar 31, 2023 | -49.39% |
| Dec 31, 2022 | -62.15% |
| Sep 30, 2022 | -33.70% |
| Jun 30, 2022 | -34.95% |
| Mar 31, 2022 | -34.49% |
| Dec 31, 2021 | -47.71% |
| Sep 30, 2021 | -90.49% |
| Jun 30, 2021 | -83.37% |
| Mar 31, 2021 | -76.25% |
API Access
Karyopharm Therapeutics Return on Capital Employed [ROCE] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-capital-employed-%5Broce%5D&ticker=KPTI&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-capital-employed-[roce]", "ticker": "KPTI", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-capital-employed-%5Broce%5D&ticker=KPTI&period=max&api_key=YOUR_API_KEY");
const data = await res.json();