Karyopharm Therapeutics (KPTI) Operating Margin (2012 - 2026)
Karyopharm Therapeutics' Operating Margin was -67.38% in Q2 2026, down 3.08 percentage points from -64.30% a year earlier.
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Analysis
Karyopharm Therapeutics (KPTI) Operating Margin (2012 - 2026) Analysis & Trends
On a trailing twelve-month basis, Karyopharm Therapeutics' Operating Margin was -53.50% through Jun 30, 2026, up 30.43 percentage points year-over-year; for FY2025, it came in at -62.10%, up 20.14 percentage points from FY2024.
- Operating Margin has now increased for three consecutive years, with a five-year change of +96.90 percentage points (FY2020 to FY2025).
- In earlier years, Operating Margin was -82.24% in FY2024 (+6.47 pp), -88.71% in FY2023 (+1.83 pp), -90.53% in FY2022 (-43.70 pp) and -46.84% in FY2021 (+112.16 pp).
- The Q2 2026 figure marks the lowest quarterly Operating Margin since Q1 2025.
- Compared with a year earlier, Operating Margin was higher in five of the last seven quarters, with an average year-over-year change of +14.48 percentage points.
- The best year-over-year quarter for Operating Margin over five years was Q1 2022 (a gain of 152.61 percentage points); the worst was Q4 2022 (a drop of 138.05 percentage points).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,136.97 Bn | 1,105.55 Bn | 19.71 Bn | 51.16% |
| 2 | Johnson & Johnson | 619.72 Bn | 538.25 Bn | 17.26 Bn | 28.21% |
| 3 | AbbVie | 503.40 Bn | 476.52 Bn | 12.70 Bn | 37.86% |
| 4 | Merck | 370.15 Bn | 324.53 Bn | 12.21 Bn | -3.52% |
| 5 | Novartis Ag | 298.64 Bn | 262.63 Bn | 11.24 Bn | 32.97% |
| 6 | Astrazeneca | 261.07 Bn | 234.76 Bn | 12.86 Bn | 20.57% |
| 7 | Amgen | 237.00 Bn | 192.40 Bn | 7.24 Bn | 34.95% |
| 8 | Gilead Sciences | 191.24 Bn | 165.43 Bn | 6.22 Bn | -133.21% |
| 9 | Pfizer | 170.31 Bn | 116.96 Bn | 10.94 Bn | 28.37% |
| 10 | Karyopharm Therapeutics | 12.16 Mn | -214.27 Mn | 32.35 Mn | -67.38% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -67.38% |
| Dec 31, 2025 | -52.36% |
| Sep 30, 2025 | -34.56% |
| Jun 30, 2025 | -64.30% |
| Mar 31, 2025 | -110.80% |
| Dec 31, 2024 | -102.42% |
| Sep 30, 2024 | -67.77% |
| Jun 30, 2024 | -65.72% |
| Mar 31, 2024 | -101.91% |
| Dec 31, 2023 | -112.03% |
| Sep 30, 2023 | -86.81% |
| Jun 30, 2023 | -78.70% |
| Mar 31, 2023 | -79.85% |
| Dec 31, 2022 | -100.86% |
| Sep 30, 2022 | -85.32% |
| Jun 30, 2022 | -108.14% |
| Mar 31, 2022 | -72.55% |
| Dec 31, 2021 | 37.19% |
| Sep 30, 2021 | -116.25% |
| Jun 30, 2021 | -217.02% |
API Access
Karyopharm Therapeutics Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=KPTI&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "KPTI", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=KPTI&period=max&api_key=YOUR_API_KEY");
const data = await res.json();