Karyopharm Therapeutics (KPTI) Operating Leases (2019 - 2025)

Karyopharm Therapeutics (KPTI) reported Operating Leases of $5.7 million for Q4 2025, down 14.44% on a YoY basis from $6.7 million in Q4 2024, and down 4.41% quarter-over-quarter from $6.0 million in Q3 2025.

Karyopharm Therapeutics (KPTI) Operating Leases (2019 - 2025) Analysis & Trends

Karyopharm Therapeutics has reported Operating Leases for 7 years, with the latest figure at $5.7 million in Q4 2025.

  • For the quarter ending Q4 2025, Operating Leases fell 14.44% year-over-year to $5.7 million; the trailing twelve-month figure through Dec 2025 stood at $5.7 million (down 14.44% YoY), and the FY2025 full-year result was $5.7 million, down 14.44% from the prior year.
  • Operating Leases for Q4 2025 stood at $5.7 million, down from $6.0 million in the prior quarter.
  • The five-year high for Operating Leases was $10.7 million in Q1 2021, with the low at $955000.0 in Q2 2024.
  • Historically, Operating Leases has averaged $6.2 million across 5 years, with a median of $6.3 million in 2025.
  • Annual changes were most pronounced in 2024 — Operating Leases slumped 78.78% — and 2025, when it surged 554.55%.
  • Karyopharm Therapeutics' Operating Leases stood at $9.0 million in 2021, then sank by 32.02% to $6.1 million in 2022, then sank by 54.26% to $2.8 million in 2023, then surged by 140.66% to $6.7 million in 2024, then dropped by 14.44% to $5.7 million in 2025.
  • The last three Operating Leases figures came in at $5.7 million (Q4 2025), $6.0 million (Q3 2025), and $6.3 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr)
1 Alterity Therapeutics 762,369.55 Bn 762,369.51 Bn -
2 Belite Bio 55,096.00 Bn 55,096.00 Bn -
3 Quantum Biopharma 17,755.80 Bn 17,755.79 Bn -
4 Legend Biotech 3,486.00 Bn 3,485.71 Bn 242.10 Mn
5 Akari Therapeutics 1,737.42 Bn 1,737.41 Bn -
6 Evaxion A 1,551.28 Bn 1,551.26 Bn -
7 Psyence Biomedical 227.32 Bn 227.31 Bn -
8 Vertex Pharmaceuticals 110.84 Bn 103.59 Bn 2.59 Bn
9 Abivax 91.71 Bn 91.71 Bn -
10 Karyopharm Therapeutics 95.31 Mn 31.56 Mn 32.74 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 5.74 Mn
Sep 30, 2025 6.01 Mn
Jun 30, 2025 6.25 Mn
Mar 31, 2025 6.49 Mn
Dec 31, 2024 6.71 Mn
Jun 30, 2024 955,000.00
Mar 31, 2024 1.88 Mn
Dec 31, 2023 2.79 Mn
Sep 30, 2023 3.67 Mn
Jun 30, 2023 4.50 Mn
Mar 31, 2023 5.31 Mn
Dec 31, 2022 6.10 Mn
Sep 30, 2022 6.86 Mn
Jun 30, 2022 7.58 Mn
Mar 31, 2022 8.29 Mn
Dec 31, 2021 8.97 Mn
Sep 30, 2021 9.63 Mn
Jun 30, 2021 10.20 Mn
Mar 31, 2021 10.75 Mn
Dec 31, 2020 11.29 Mn