Karyopharm Therapeutics (KPTI) Operating Expenses (2012 - 2026)
Karyopharm Therapeutics (KPTI) posted Operating Expenses of $55.96 million for Q2 2026, down 10.2% from $62.32 million a year earlier.
Powered by 
Analysis
Karyopharm Therapeutics (KPTI) Operating Expenses (2012 - 2026) Analysis & Trends
For the trailing twelve months through Jun 30, 2026, Operating Expenses at Karyopharm Therapeutics was $229.46 million, down 9.1% year-over-year; for FY2025, it came in at $236.77 million, down 10.5% from FY2024.
- Annual Operating Expenses has declined for four consecutive years, with a five-year compound annual growth rate of -3.3% (FY2020 to FY2025).
- In prior years, Karyopharm Therapeutics' Operating Expenses was $264.68 million in FY2024 (-4.0%), $275.57 million in FY2023 (-7.9%), $299.28 million in FY2022 (-2.9%) and $308.09 million in FY2021 (+10.1%).
- Quarterly Operating Expenses has run from a low of $51.92 million in Q4 2025 to a high of $82.59 million in Q2 2022 over five years.
- The strongest year-over-year quarter for Operating Expenses in the past five years was Q3 2021, with growth of 19.1%; the weakest was Q2 2023, with a decline of 18.7%.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Opex (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,136.97 Bn | 1,105.55 Bn | 19.71 Bn | 7.95 Bn |
| 2 | Johnson & Johnson | 619.72 Bn | 538.25 Bn | 17.26 Bn | 10.12 Bn |
| 3 | AbbVie | 503.40 Bn | 476.52 Bn | 12.70 Bn | 10.56 Bn |
| 4 | Merck | 370.15 Bn | 324.53 Bn | 12.21 Bn | 12.80 Bn |
| 5 | Novartis Ag | 298.64 Bn | 262.63 Bn | 11.24 Bn | 6.09 Bn |
| 6 | Astrazeneca | 261.07 Bn | 234.76 Bn | 12.86 Bn | 9.70 Bn |
| 7 | Amgen | 237.00 Bn | 192.40 Bn | 7.24 Bn | 6.54 Bn |
| 8 | Gilead Sciences | 191.24 Bn | 165.43 Bn | 6.22 Bn | 18.20 Bn |
| 9 | Pfizer | 170.31 Bn | 116.96 Bn | 10.94 Bn | 6.68 Bn |
| 10 | Karyopharm Therapeutics | 12.16 Mn | -214.27 Mn | 32.35 Mn | 55.96 Mn |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | 55.96 Mn |
| Dec 31, 2025 | 51.92 Mn |
| Sep 30, 2025 | 59.26 Mn |
| Jun 30, 2025 | 62.32 Mn |
| Mar 31, 2025 | 63.27 Mn |
| Dec 31, 2024 | 61.82 Mn |
| Sep 30, 2024 | 65.07 Mn |
| Jun 30, 2024 | 70.91 Mn |
| Mar 31, 2024 | 66.89 Mn |
| Dec 31, 2023 | 71.56 Mn |
| Sep 30, 2023 | 67.27 Mn |
| Jun 30, 2023 | 67.15 Mn |
| Mar 31, 2023 | 69.60 Mn |
| Dec 31, 2022 | 67.45 Mn |
| Sep 30, 2022 | 66.98 Mn |
| Jun 30, 2022 | 82.59 Mn |
| Mar 31, 2022 | 82.26 Mn |
| Dec 31, 2021 | 79.31 Mn |
| Sep 30, 2021 | 81.50 Mn |
| Jun 30, 2021 | 71.65 Mn |
API Access
Karyopharm Therapeutics Operating Expenses API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-expenses&ticker=KPTI&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-expenses", "ticker": "KPTI", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-expenses&ticker=KPTI&period=max&api_key=YOUR_API_KEY");
const data = await res.json();