Karyopharm Therapeutics (KPTI) Non Operating Income (2013 - 2026)
Karyopharm Therapeutics' (KPTI) quarterly Non Operating Income came in at -$84.4 million in Q4 2025, down 21635.97% YoY from N/an in Q4 2024, and down 372.34% on a QoQ basis from -$17.9 million in Q3 2025.
Karyopharm Therapeutics (KPTI) Non Operating Income (2013 - 2026) Analysis & Trends
Karyopharm Therapeutics (KPTI) has 13 years of Non Operating Income data on file, last reported at -$84.4 million in Q4 2025.
- Quarterly Non Operating Income fell 21635.97% year-over-year to -$84.4 million in Q4 2025, while the trailing twelve-month figure through Dec 2025 was -$105.3 million (down 344.41% YoY) and the FY2025 annual result came in at -$105.3 million, down 344.41% from the prior year.
- Non Operating Income slipped to -$84.4 million in Q4 2025, from -$17.9 million in the prior quarter.
- In the past five years, Non Operating Income ranged from a high of $52.0 million in Q2 2024 to a low of -$84.4 million in Q4 2025.
- A 5-year average of -$6.2 million and a median of -$4.7 million in 2021 frame the typical range for Non Operating Income.
- Annual changes were most pronounced in 2024 — Non Operating Income surged 1874.03% — and 2025, when it tumbled 21635.97%.
- Tracing KPTI's Non Operating Income over 5 years: stood at -$8.4 million in 2021, then surged by 45.43% to -$4.6 million in 2022, then rose by 14.57% to -$3.9 million in 2023, then surged by 110.05% to $392000.0 in 2024, then plunged by 21635.97% to -$84.4 million in 2025.
- The last three Non Operating Income figures came in at -$84.4 million (Q4 2025), -$17.9 million (Q3 2025), and -$12.8 million (Q2 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Non Op. Inc. (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 139.13 Bn | 131.28 Bn | 2.84 Bn | - |
| 2 | Regeneron Pharmaceuticals | 85.77 Bn | 77.77 Bn | 3.93 Bn | 234.30 Mn |
| 3 | Argenx Se | 64.64 Bn | 59.46 Bn | 1.37 Bn | - |
| 4 | Moderna | 58.29 Bn | 53.16 Bn | 52.00 Mn | - |
| 5 | BeOne Medicines | 41.92 Bn | 36.82 Bn | 1.53 Bn | - |
| 6 | Alnylam Pharmaceuticals | 31.58 Bn | 28.28 Bn | 992.69 Mn | -53.64 Mn |
| 7 | BioNTech SE | 28.12 Bn | 9.73 Bn | 668.28 Mn | - |
| 8 | Insmed | 27.39 Bn | 26.22 Bn | 358.27 Mn | - |
| 9 | Royalty Pharma | 27.27 Bn | 26.43 Bn | - | -51.63 Mn |
| 10 | Karyopharm Therapeutics | 56.72 Mn | 56.72 Mn | 32.35 Mn | -44.50 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Jun 30, 2026 | -44.50 Mn |
| Dec 31, 2025 | -84.42 Mn |
| Sep 30, 2025 | -17.87 Mn |
| Jun 30, 2025 | -12.83 Mn |
| Mar 31, 2025 | 9.83 Mn |
| Dec 31, 2024 | 392,000.00 |
| Sep 30, 2024 | -5.76 Mn |
| Jun 30, 2024 | 51.98 Mn |
| Mar 31, 2024 | -3.53 Mn |
| Dec 31, 2023 | -3.90 Mn |
| Sep 30, 2023 | -3.23 Mn |
| Jun 30, 2023 | -2.93 Mn |
| Mar 31, 2023 | -3.17 Mn |
| Dec 31, 2022 | -4.56 Mn |
| Sep 30, 2022 | -5.44 Mn |
| Jun 30, 2022 | -6.03 Mn |
| Mar 31, 2022 | -6.68 Mn |
| Dec 31, 2021 | -8.36 Mn |
| Sep 30, 2021 | -7.89 Mn |
| Jun 30, 2021 | -4.40 Mn |