Karyopharm Therapeutics KPTI
NASDAQ KPTI
$1.96 +0.14 (+7.69%)
At close: Aug 21, 2026 · 4:00 PM EDT

Karyopharm Therapeutics (KPTI) Non Operating Income (2013 - 2026)

Karyopharm Therapeutics' (KPTI) quarterly Non Operating Income came in at -$84.4 million in Q4 2025, down 21635.97% YoY from N/an in Q4 2024, and down 372.34% on a QoQ basis from -$17.9 million in Q3 2025.

Karyopharm Therapeutics (KPTI) Non Operating Income (2013 - 2026) Analysis & Trends

Karyopharm Therapeutics (KPTI) has 13 years of Non Operating Income data on file, last reported at -$84.4 million in Q4 2025.

  • Quarterly Non Operating Income fell 21635.97% year-over-year to -$84.4 million in Q4 2025, while the trailing twelve-month figure through Dec 2025 was -$105.3 million (down 344.41% YoY) and the FY2025 annual result came in at -$105.3 million, down 344.41% from the prior year.
  • Non Operating Income slipped to -$84.4 million in Q4 2025, from -$17.9 million in the prior quarter.
  • In the past five years, Non Operating Income ranged from a high of $52.0 million in Q2 2024 to a low of -$84.4 million in Q4 2025.
  • A 5-year average of -$6.2 million and a median of -$4.7 million in 2021 frame the typical range for Non Operating Income.
  • Annual changes were most pronounced in 2024 — Non Operating Income surged 1874.03% — and 2025, when it tumbled 21635.97%.
  • Tracing KPTI's Non Operating Income over 5 years: stood at -$8.4 million in 2021, then surged by 45.43% to -$4.6 million in 2022, then rose by 14.57% to -$3.9 million in 2023, then surged by 110.05% to $392000.0 in 2024, then plunged by 21635.97% to -$84.4 million in 2025.
  • The last three Non Operating Income figures came in at -$84.4 million (Q4 2025), -$17.9 million (Q3 2025), and -$12.8 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Non Op. Inc. (Qtr)
1 Vertex Pharmaceuticals 139.13 Bn 131.28 Bn 2.84 Bn -
2 Regeneron Pharmaceuticals 85.77 Bn 77.77 Bn 3.93 Bn 234.30 Mn
3 Argenx Se 64.64 Bn 59.46 Bn 1.37 Bn -
4 Moderna 58.29 Bn 53.16 Bn 52.00 Mn -
5 BeOne Medicines 41.92 Bn 36.82 Bn 1.53 Bn -
6 Alnylam Pharmaceuticals 31.58 Bn 28.28 Bn 992.69 Mn -53.64 Mn
7 BioNTech SE 28.12 Bn 9.73 Bn 668.28 Mn -
8 Insmed 27.39 Bn 26.22 Bn 358.27 Mn -
9 Royalty Pharma 27.27 Bn 26.43 Bn - -51.63 Mn
10 Karyopharm Therapeutics 56.72 Mn 56.72 Mn 32.35 Mn -44.50 Mn

Historic Data

Download Data
DateValue
Jun 30, 2026 -44.50 Mn
Dec 31, 2025 -84.42 Mn
Sep 30, 2025 -17.87 Mn
Jun 30, 2025 -12.83 Mn
Mar 31, 2025 9.83 Mn
Dec 31, 2024 392,000.00
Sep 30, 2024 -5.76 Mn
Jun 30, 2024 51.98 Mn
Mar 31, 2024 -3.53 Mn
Dec 31, 2023 -3.90 Mn
Sep 30, 2023 -3.23 Mn
Jun 30, 2023 -2.93 Mn
Mar 31, 2023 -3.17 Mn
Dec 31, 2022 -4.56 Mn
Sep 30, 2022 -5.44 Mn
Jun 30, 2022 -6.03 Mn
Mar 31, 2022 -6.68 Mn
Dec 31, 2021 -8.36 Mn
Sep 30, 2021 -7.89 Mn
Jun 30, 2021 -4.40 Mn