Karyopharm Therapeutics (KPTI) Interest Coverage Ratio (2015 - 2025)
Karyopharm Therapeutics (KPTI) reported Interest Coverage Ratio of 2.51 for Q4 2025, up 189.99% on a YoY basis from 0.87 in Q4 2024, and up 281.71% quarter-over-quarter from 1.38 in Q3 2025.
Karyopharm Therapeutics (KPTI) Interest Coverage Ratio (2015 - 2025) Analysis & Trends
Karyopharm Therapeutics has reported Interest Coverage Ratio for 8 years, with the latest figure at 2.51 in Q4 2025.
- For the quarter ending Q4 2025, Interest Coverage Ratio rose 189.99% year-over-year to 2.51; the trailing twelve-month figure through Dec 2025 stood at 0.9 (up 71.87% YoY), and the FY2025 full-year result was 0.9, up 71.87% from the prior year.
- Interest Coverage Ratio for Q4 2025 stood at 2.51, up from 1.38 in the prior quarter.
- The five-year high for Interest Coverage Ratio was 5.91 in Q4 2021, with the low at 10.28 in Q1 2021.
- Historically, Interest Coverage Ratio has averaged 4.11 across 5 years, with a median of 5.13 in 2023.
- Annual changes were most pronounced in 2021 — Interest Coverage Ratio soared 212.85% — and 2022, when it slumped 197.3%.
- Karyopharm Therapeutics' Interest Coverage Ratio stood at 5.91 in 2021, then plunged by 197.3% to 5.76 in 2022, then slipped by 5.82% to 6.09 in 2023, then soared by 54.16% to 2.79 in 2024, then surged by 189.99% to 2.51 in 2025.
- The last three Interest Coverage Ratio figures came in at 2.51 (Q4 2025), 1.38 (Q3 2025), and 2.17 (Q2 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Interest Cover (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 762,369.55 Bn | 762,369.51 Bn | - | - |
| 2 | Belite Bio | 55,096.00 Bn | 55,096.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,755.80 Bn | 17,755.79 Bn | - | - |
| 4 | Legend Biotech | 3,486.00 Bn | 3,485.71 Bn | 242.10 Mn | 3.58 |
| 5 | Akari Therapeutics | 1,737.42 Bn | 1,737.41 Bn | - | -258.33 |
| 6 | Evaxion A | 1,551.28 Bn | 1,551.26 Bn | - | 11.50 |
| 7 | Psyence Biomedical | 227.32 Bn | 227.31 Bn | - | 547.67 |
| 8 | Vertex Pharmaceuticals | 110.84 Bn | 103.59 Bn | 2.59 Bn | - |
| 9 | Abivax | 91.71 Bn | 91.71 Bn | - | 11.79 |
| 10 | Karyopharm Therapeutics | 95.31 Mn | 31.56 Mn | 32.74 Mn | 2.51 |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 2.51 |
| Sep 30, 2025 | -1.38 |
| Jun 30, 2025 | -2.17 |
| Mar 31, 2025 | -3.02 |
| Dec 31, 2024 | -2.79 |
| Sep 30, 2024 | -2.31 |
| Jun 30, 2024 | -3.14 |
| Mar 31, 2024 | -5.74 |
| Dec 31, 2023 | -6.09 |
| Sep 30, 2023 | -5.15 |
| Jun 30, 2023 | -5.11 |
| Mar 31, 2023 | -5.37 |
| Dec 31, 2022 | -5.76 |
| Sep 30, 2022 | -5.04 |
| Jun 30, 2022 | -6.80 |
| Mar 31, 2022 | -5.17 |
| Dec 31, 2021 | 5.91 |
| Sep 30, 2021 | -5.47 |
| Jun 30, 2021 | -9.81 |
| Mar 31, 2021 | -10.28 |