Karyopharm Therapeutics (KPTI) FCF Margin (2012 - 2025)
Karyopharm Therapeutics' FCF Margin was -34.71% in Q4 2025, up 49.63 percentage points from -84.33% a year earlier but down 21.40 percentage points from the prior quarter.
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Analysis
Karyopharm Therapeutics (KPTI) FCF Margin (2012 - 2025) Analysis & Trends
For FY2025, FCF Margin at Karyopharm Therapeutics came in at -51.60%, up 36.28 percentage points from FY2024.
- FCF Margin shows a five-year change of +96.78 percentage points (FY2020 to FY2025).
- In earlier years, FCF Margin was -87.88% in FY2024 (-24.38 pp), -63.49% in FY2023 (+31.79 pp), -95.29% in FY2022 (-44.13 pp) and -51.15% in FY2021 (+97.23 pp).
- Quarterly FCF Margin has moved between -246.66% (Q2 2021) and 20.01% (Q4 2021) over five years.
- Compared with a year earlier, FCF Margin has increased for four straight quarters, with an average year-over-year change of +3.39 percentage points over the last eight quarters.
- The best year-over-year quarter for FCF Margin over five years was Q2 2022 (a gain of 158.09 percentage points); the worst was Q2 2021 (a drop of 126.43 percentage points).
- Per Business Quant data, KPTI's FCF Margin in the three quarters before Q4 2025 was -13.30% (Q3 2025), -49.29% (Q2 2025) and -129.88% (Q1 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | FCF Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,136.97 Bn | 1,105.55 Bn | 19.71 Bn | 33.76% |
| 2 | Johnson & Johnson | 619.72 Bn | 538.25 Bn | 17.26 Bn | 28.82% |
| 3 | AbbVie | 503.40 Bn | 476.52 Bn | 12.70 Bn | 18.33% |
| 4 | Merck | 370.15 Bn | 324.53 Bn | 12.21 Bn | 26.96% |
| 5 | Novartis Ag | 298.64 Bn | 262.63 Bn | 11.24 Bn | 38.60% |
| 6 | Astrazeneca | 261.07 Bn | 234.76 Bn | 12.86 Bn | 6.55% |
| 7 | Amgen | 237.00 Bn | 192.40 Bn | 7.24 Bn | 34.70% |
| 8 | Gilead Sciences | 191.24 Bn | 165.43 Bn | 6.22 Bn | 44.00% |
| 9 | Pfizer | 170.31 Bn | 116.96 Bn | 10.94 Bn | 2.01% |
| 10 | Karyopharm Therapeutics | 12.16 Mn | -214.27 Mn | 32.35 Mn | - |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Dec 31, 2025 | -34.71% |
| Sep 30, 2025 | -13.30% |
| Jun 30, 2025 | -49.29% |
| Mar 31, 2025 | -129.88% |
| Dec 31, 2024 | -84.33% |
| Sep 30, 2024 | -50.16% |
| Jun 30, 2024 | -89.98% |
| Mar 31, 2024 | -132.58% |
| Dec 31, 2023 | -55.07% |
| Sep 30, 2023 | -82.01% |
| Jun 30, 2023 | -68.38% |
| Mar 31, 2023 | -48.87% |
| Dec 31, 2022 | -79.94% |
| Sep 30, 2022 | -78.60% |
| Jun 30, 2022 | -88.57% |
| Mar 31, 2022 | -124.35% |
| Dec 31, 2021 | 20.01% |
| Sep 30, 2021 | -63.57% |
| Jun 30, 2021 | -246.66% |
| Mar 31, 2021 | -227.38% |
API Access
Karyopharm Therapeutics FCF Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=fcf-margin&ticker=KPTI&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "fcf-margin", "ticker": "KPTI", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=fcf-margin&ticker=KPTI&period=max&api_key=YOUR_API_KEY");
const data = await res.json();