Karyopharm Therapeutics (KPTI) EBT (2012 - 2026)
Karyopharm Therapeutics' (KPTI) quarterly EBT came in at -$67.0 million in Q2 2026, down 80.11% on a YoY basis from -$337.0 million in Q2 2025, and up 34.46% quarter-over-quarter from -$102.3 million in Q4 2025.
Analysis
Karyopharm Therapeutics (KPTI) EBT (2012 - 2026) Analysis & Trends
Karyopharm Therapeutics (KPTI) has reported EBT for 15 consecutive years, with -$67.0 million the latest figure, recorded in Q2 2026.
- For the quarter ending Q2 2026, EBT fell 80.11% year-over-year to -$67.0 million; the trailing twelve-month figure through Jun 2026 stood at -$239.6 million (down 93.77% YoY), and the FY2025 full-year result was -$196.0 million, down 156.39% from the prior year.
- EBT climbed to -$67.0 million in Q2 2026 per KPTI's latest filing, from -$102.3 million in the prior quarter.
- Across five years, EBT topped out at $23.9 million in Q2 2024 and bottomed at -$102.3 million in Q4 2025.
- Historically, EBT has averaged -$38.1 million across 5 years, with a median of -$36.3 million in 2022.
- The sharpest annual moves came in 2024 and 2025: EBT surged 173.41% in 2024, then plunged 255.97% in 2025.
- Over 5 years, EBT stood at -$39.3 million in 2022, then slipped by 6.69% to -$42.0 million in 2023, then climbed by 26.18% to -$31.0 million in 2024, then slumped by 230.22% to -$102.3 million in 2025, then soared by 34.46% to -$67.0 million in 2026.
- According to Business Quant data, EBT over the past three periods registered -$67.0 million, -$102.3 million, and -$33.1 million for Q2 2026, Q4 2025, and Q3 2025 respectively.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBT (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 663.08 Bn | 642.33 Bn | 17.26 Bn | 6.75 Bn |
| 2 | AbbVie | 453.04 Bn | 446.51 Bn | 12.70 Bn | 4.28 Bn |
| 3 | Merck | 370.87 Bn | 363.78 Bn | 12.21 Bn | -683.00 Mn |
| 4 | Novartis Ag | 305.29 Bn | 298.00 Bn | 11.24 Bn | 4.27 Bn |
| 5 | Pfizer | 162.10 Bn | 150.70 Bn | 10.94 Bn | -653.00 Mn |
| 6 | Sanofi | 53.95 Bn | 46.98 Bn | 10.79 Bn | 1.64 Bn |
| 7 | Revolution Medicines | 45.00 Bn | 45.00 Bn | - | -644.37 Mn |
| 8 | Incyte | 25.47 Bn | 20.94 Bn | 1.57 Bn | 751.51 Mn |
| 9 | United Therapeutics | 20.81 Bn | 18.15 Bn | 683.80 Mn | 372.70 Mn |
| 10 | Karyopharm Therapeutics | 51.80 Mn | -13.31 Mn | 32.35 Mn | -67.02 Mn |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -67.02 Mn |
| Dec 31, 2025 | -102.27 Mn |
| Sep 30, 2025 | -33.09 Mn |
| Jun 30, 2025 | -37.21 Mn |
| Mar 31, 2025 | -23.43 Mn |
| Dec 31, 2024 | -30.97 Mn |
| Sep 30, 2024 | -32.04 Mn |
| Jun 30, 2024 | 23.86 Mn |
| Mar 31, 2024 | -37.29 Mn |
| Dec 31, 2023 | -41.95 Mn |
| Sep 30, 2023 | -34.49 Mn |
| Jun 30, 2023 | -32.50 Mn |
| Mar 31, 2023 | -34.07 Mn |
| Dec 31, 2022 | -39.33 Mn |
| Sep 30, 2022 | -36.28 Mn |
| Jun 30, 2022 | -48.94 Mn |
| Mar 31, 2022 | -41.27 Mn |
| Dec 31, 2021 | 38.60 Mn |
| Sep 30, 2021 | -51.71 Mn |
| Jun 30, 2021 | -53.45 Mn |