Karyopharm Therapeutics KPTI
NASDAQ KPTI
$1.69 -0.03 (-1.74%)
As of: Sep 9, 2026 · 3:59 PM EDT

Karyopharm Therapeutics (KPTI) EBT (2012 - 2026)

Karyopharm Therapeutics' (KPTI) quarterly EBT came in at -$67.0 million in Q2 2026, down 80.11% on a YoY basis from -$337.0 million in Q2 2025, and up 34.46% quarter-over-quarter from -$102.3 million in Q4 2025.

Analysis

Karyopharm Therapeutics (KPTI) EBT (2012 - 2026) Analysis & Trends

Karyopharm Therapeutics (KPTI) has reported EBT for 15 consecutive years, with -$67.0 million the latest figure, recorded in Q2 2026.

  • For the quarter ending Q2 2026, EBT fell 80.11% year-over-year to -$67.0 million; the trailing twelve-month figure through Jun 2026 stood at -$239.6 million (down 93.77% YoY), and the FY2025 full-year result was -$196.0 million, down 156.39% from the prior year.
  • EBT climbed to -$67.0 million in Q2 2026 per KPTI's latest filing, from -$102.3 million in the prior quarter.
  • Across five years, EBT topped out at $23.9 million in Q2 2024 and bottomed at -$102.3 million in Q4 2025.
  • Historically, EBT has averaged -$38.1 million across 5 years, with a median of -$36.3 million in 2022.
  • The sharpest annual moves came in 2024 and 2025: EBT surged 173.41% in 2024, then plunged 255.97% in 2025.
  • Over 5 years, EBT stood at -$39.3 million in 2022, then slipped by 6.69% to -$42.0 million in 2023, then climbed by 26.18% to -$31.0 million in 2024, then slumped by 230.22% to -$102.3 million in 2025, then soared by 34.46% to -$67.0 million in 2026.
  • According to Business Quant data, EBT over the past three periods registered -$67.0 million, -$102.3 million, and -$33.1 million for Q2 2026, Q4 2025, and Q3 2025 respectively.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBT (Qtr)
1 Johnson & Johnson 663.08 Bn 642.33 Bn 17.26 Bn 6.75 Bn
2 AbbVie 453.04 Bn 446.51 Bn 12.70 Bn 4.28 Bn
3 Merck 370.87 Bn 363.78 Bn 12.21 Bn -683.00 Mn
4 Novartis Ag 305.29 Bn 298.00 Bn 11.24 Bn 4.27 Bn
5 Pfizer 162.10 Bn 150.70 Bn 10.94 Bn -653.00 Mn
6 Sanofi 53.95 Bn 46.98 Bn 10.79 Bn 1.64 Bn
7 Revolution Medicines 45.00 Bn 45.00 Bn - -644.37 Mn
8 Incyte 25.47 Bn 20.94 Bn 1.57 Bn 751.51 Mn
9 United Therapeutics 20.81 Bn 18.15 Bn 683.80 Mn 372.70 Mn
10 Karyopharm Therapeutics 51.80 Mn -13.31 Mn 32.35 Mn -67.02 Mn
Historic Data

Historic Data

Download Data
DateValue
Jun 30, 2026 -67.02 Mn
Dec 31, 2025 -102.27 Mn
Sep 30, 2025 -33.09 Mn
Jun 30, 2025 -37.21 Mn
Mar 31, 2025 -23.43 Mn
Dec 31, 2024 -30.97 Mn
Sep 30, 2024 -32.04 Mn
Jun 30, 2024 23.86 Mn
Mar 31, 2024 -37.29 Mn
Dec 31, 2023 -41.95 Mn
Sep 30, 2023 -34.49 Mn
Jun 30, 2023 -32.50 Mn
Mar 31, 2023 -34.07 Mn
Dec 31, 2022 -39.33 Mn
Sep 30, 2022 -36.28 Mn
Jun 30, 2022 -48.94 Mn
Mar 31, 2022 -41.27 Mn
Dec 31, 2021 38.60 Mn
Sep 30, 2021 -51.71 Mn
Jun 30, 2021 -53.45 Mn