Karyopharm Therapeutics (KPTI) EBITDA Margin (2012 - 2025)
Karyopharm Therapeutics (KPTI) recorded EBITDA Margin of -52.30% in Q4 2025, up 49.85 percentage points from -102.15% a year earlier but down 18.02 percentage points from the prior quarter.
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Analysis
Karyopharm Therapeutics (KPTI) EBITDA Margin (2012 - 2025) Analysis & Trends
For FY2025, Karyopharm Therapeutics reported EBITDA Margin of -61.90%, up 20.11 percentage points from FY2024.
- Annual EBITDA Margin has increased for three straight years, with a five-year change of +96.20 percentage points (FY2020 to FY2025).
- Across earlier years, EBITDA Margin came in at -82.01% in FY2024 (+6.34 pp), -88.34% in FY2023 (+1.79 pp), -90.14% in FY2022 (-43.68 pp) and -46.46% in FY2021 (+111.64 pp).
- Quarterly EBITDA Margin has ranged from -224.15% in Q1 2021 to 37.30% in Q4 2021 over the past five years.
- On a year-over-year basis, EBITDA Margin has increased for three consecutive quarters, with an average year-over-year change of +11.84 percentage points over the last eight quarters.
- Peak year-over-year performance for EBITDA Margin in the last five years was a gain of 151.97 percentage points in Q1 2022, against a drop of 137.83 percentage points in Q4 2022 at the low end.
- Per Business Quant, the preceding three quarters came in at -34.28% (Q3 2025), -64.09% (Q2 2025) and -110.54% (Q1 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,136.97 Bn | 1,105.55 Bn | 19.71 Bn | 53.49% |
| 2 | Johnson & Johnson | 619.72 Bn | 538.25 Bn | 17.26 Bn | 35.95% |
| 3 | AbbVie | 503.40 Bn | 476.52 Bn | 12.70 Bn | 49.01% |
| 4 | Merck | 370.15 Bn | 324.53 Bn | 12.21 Bn | 6.02% |
| 5 | Novartis Ag | 298.64 Bn | 262.63 Bn | 11.24 Bn | - |
| 6 | Astrazeneca | 261.07 Bn | 234.76 Bn | 12.86 Bn | 33.11% |
| 7 | Amgen | 237.00 Bn | 192.40 Bn | 7.24 Bn | 46.01% |
| 8 | Gilead Sciences | 191.24 Bn | 165.43 Bn | 6.22 Bn | -124.26% |
| 9 | Pfizer | 170.31 Bn | 116.96 Bn | 10.94 Bn | 39.16% |
| 10 | Karyopharm Therapeutics | 12.16 Mn | -214.27 Mn | 32.35 Mn | - |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Dec 31, 2025 | -45.13% |
| Sep 30, 2025 | -27.91% |
| Jun 30, 2025 | -56.92% |
| Mar 31, 2025 | -101.97% |
| Dec 31, 2024 | -94.44% |
| Sep 30, 2024 | -61.35% |
| Jun 30, 2024 | -62.24% |
| Mar 31, 2024 | -101.03% |
| Dec 31, 2023 | -111.16% |
| Sep 30, 2023 | -86.02% |
| Jun 30, 2023 | -77.97% |
| Mar 31, 2023 | -78.58% |
| Dec 31, 2022 | -99.90% |
| Sep 30, 2022 | -84.26% |
| Jun 30, 2022 | -107.25% |
| Mar 31, 2022 | -71.77% |
| Dec 31, 2021 | 37.46% |
| Sep 30, 2021 | -115.24% |
| Jun 30, 2021 | -215.14% |
| Mar 31, 2021 | -223.33% |
API Access
Karyopharm Therapeutics EBITDA Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=ebitda-margin&ticker=KPTI&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "ebitda-margin", "ticker": "KPTI", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=ebitda-margin&ticker=KPTI&period=max&api_key=YOUR_API_KEY");
const data = await res.json();