Karyopharm Therapeutics (KPTI) EBITDA (2012 - 2025)
Karyopharm Therapeutics (KPTI) posted EBITDA of -$17.83 million for Q4 2025, compared with -$31.2 million a year earlier.
Powered by 
Analysis
Karyopharm Therapeutics (KPTI) EBITDA (2012 - 2025) Analysis & Trends
For FY2025, Karyopharm Therapeutics' EBITDA came in at -$90.41 million.
- In prior years, Karyopharm Therapeutics' EBITDA was -$119.1 million in FY2024, -$129.01 million in FY2023, -$141.58 million in FY2022 and -$97.48 million in FY2021.
- Quarterly EBITDA has run from a low of -$52.14 million in Q1 2021 to a high of $47.1 million in Q4 2021 over five years.
- According to Business Quant data, EBITDA for the three prior quarters was -$15.1 million (Q3 2025), -$24.31 million (Q2 2025) and -$33.18 million (Q1 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,136.97 Bn | 1,105.55 Bn | 19.71 Bn | 12.29 Bn |
| 2 | Johnson & Johnson | 619.72 Bn | 538.25 Bn | 17.26 Bn | 9.10 Bn |
| 3 | AbbVie | 503.40 Bn | 476.52 Bn | 12.70 Bn | 8.33 Bn |
| 4 | Merck | 370.15 Bn | 324.53 Bn | 12.21 Bn | 999.00 Mn |
| 5 | Novartis Ag | 298.64 Bn | 262.63 Bn | 11.24 Bn | - |
| 6 | Astrazeneca | 261.07 Bn | 234.76 Bn | 12.86 Bn | 5.09 Bn |
| 7 | Amgen | 237.00 Bn | 192.40 Bn | 7.24 Bn | 4.63 Bn |
| 8 | Gilead Sciences | 191.24 Bn | 165.43 Bn | 6.22 Bn | -9.70 Bn |
| 9 | Pfizer | 170.31 Bn | 116.96 Bn | 10.94 Bn | 5.89 Bn |
| 10 | Karyopharm Therapeutics | 12.16 Mn | -214.27 Mn | 32.35 Mn | - |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Dec 31, 2025 | -15.38 Mn |
| Sep 30, 2025 | -12.29 Mn |
| Jun 30, 2025 | -21.59 Mn |
| Mar 31, 2025 | -30.61 Mn |
| Dec 31, 2024 | -28.84 Mn |
| Sep 30, 2024 | -23.79 Mn |
| Jun 30, 2024 | -26.63 Mn |
| Mar 31, 2024 | -33.47 Mn |
| Dec 31, 2023 | -37.51 Mn |
| Sep 30, 2023 | -30.98 Mn |
| Jun 30, 2023 | -29.30 Mn |
| Mar 31, 2023 | -30.41 Mn |
| Dec 31, 2022 | -33.55 Mn |
| Sep 30, 2022 | -30.46 Mn |
| Jun 30, 2022 | -42.56 Mn |
| Mar 31, 2022 | -34.21 Mn |
| Dec 31, 2021 | 47.30 Mn |
| Sep 30, 2021 | -43.43 Mn |
| Jun 30, 2021 | -48.62 Mn |
| Mar 31, 2021 | -51.95 Mn |
API Access
Karyopharm Therapeutics EBITDA API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=ebitda&ticker=KPTI&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "ebitda", "ticker": "KPTI", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=ebitda&ticker=KPTI&period=max&api_key=YOUR_API_KEY");
const data = await res.json();