Karyopharm Therapeutics Inc. (KPTI) EBIT Margin (2012 - 2026)
Karyopharm Therapeutics (KPTI) recorded EBIT Margin of -67.38% in Q2 2026, down 3.08 percentage points from -64.30% a year earlier.
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Analysis
Karyopharm Therapeutics Inc. (KPTI) EBIT Margin (2012 - 2026) Analysis & Trends
On a TTM basis, Karyopharm Therapeutics' EBIT Margin came in at -53.50% as of Jun 30, 2026, up 30.43 percentage points year-over-year; for FY2025, it came in at -62.10%, up 20.14 percentage points from FY2024.
- Annual EBIT Margin has increased for three straight years, with a five-year change of +96.90 percentage points (FY2020 to FY2025).
- Across earlier years, EBIT Margin came in at -82.24% in FY2024 (+6.47 pp), -88.71% in FY2023 (+1.83 pp), -90.53% in FY2022 (-43.70 pp) and -46.84% in FY2021 (+112.16 pp).
- The Q2 2026 figure is the lowest quarterly EBIT Margin since Q1 2025.
- On a year-over-year basis, EBIT Margin rose in five of the last seven quarters, with an average year-over-year change of +14.48 percentage points.
- Peak year-over-year performance for EBIT Margin in the last five years was a gain of 152.61 percentage points in Q1 2022, against a drop of 138.05 percentage points in Q4 2022 at the low end.
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Historic Data
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Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -67.38% |
| Dec 31, 2025 | -52.36% |
| Sep 30, 2025 | -34.56% |
| Jun 30, 2025 | -64.30% |
| Mar 31, 2025 | -110.80% |
| Dec 31, 2024 | -102.42% |
| Sep 30, 2024 | -67.77% |
| Jun 30, 2024 | -65.72% |
| Mar 31, 2024 | -101.91% |
| Dec 31, 2023 | -112.03% |
| Sep 30, 2023 | -86.81% |
| Jun 30, 2023 | -78.70% |
| Mar 31, 2023 | -79.85% |
| Dec 31, 2022 | -100.86% |
| Sep 30, 2022 | -85.32% |
| Jun 30, 2022 | -108.14% |
| Mar 31, 2022 | -72.55% |
| Dec 31, 2021 | 37.19% |
| Sep 30, 2021 | -116.25% |
| Jun 30, 2021 | -217.02% |
API Access
Karyopharm Therapeutics Inc. EBIT Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=ebit-margin&ticker=KPTI&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "ebit-margin", "ticker": "KPTI", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=ebit-margin&ticker=KPTI&period=max&api_key=YOUR_API_KEY");
const data = await res.json();