Karyopharm Therapeutics (KPTI) EBIT (2012 - 2026)
Karyopharm Therapeutics' (KPTI) quarterly EBIT came in at -$22.5 million in Q2 2026, up 7.63% on a YoY basis from -$20.9 million in Q2 2025, and down 26.24% quarter-over-quarter from -$17.8 million in Q4 2025.
Analysis
Karyopharm Therapeutics (KPTI) EBIT (2012 - 2026) Analysis & Trends
Karyopharm Therapeutics (KPTI) has reported EBIT for 15 consecutive years, with -$22.5 million the latest figure, recorded in Q2 2026.
- For the quarter ending Q2 2026, EBIT rose 7.63% year-over-year to -$22.5 million; the trailing twelve-month figure through Jun 2026 stood at -$80.0 million (up 30.58% YoY), and the FY2025 full-year result was -$90.7 million, up 24.06% from the prior year.
- EBIT eased to -$22.5 million in Q2 2026 per KPTI's latest filing, from -$17.8 million in the prior quarter.
- Across five years, EBIT topped out at -$15.2 million in Q3 2025 and bottomed at -$42.9 million in Q2 2022.
- Historically, EBIT has averaged -$29.7 million across 5 years, with a median of -$30.9 million in 2023.
- The sharpest annual moves came in 2022 and 2025: EBIT sank 172.12% in 2022, then jumped 42.96% in 2025.
- Over 5 years, EBIT stood at -$33.9 million in 2022, then fell by 11.63% to -$37.8 million in 2023, then gained by 17.26% to -$31.3 million in 2024, then surged by 42.96% to -$17.8 million in 2025, then fell by 26.24% to -$22.5 million in 2026.
- According to Business Quant data, EBIT over the past three periods registered -$22.5 million, -$17.8 million, and -$15.2 million for Q2 2026, Q4 2025, and Q3 2025 respectively.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBIT (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 641.30 Bn | 620.54 Bn | 17.26 Bn | 7.14 Bn |
| 2 | AbbVie | 446.34 Bn | 439.77 Bn | 12.70 Bn | 6.43 Bn |
| 3 | Merck | 357.25 Bn | 350.11 Bn | 12.21 Bn | -584.00 Mn |
| 4 | Novartis Ag | 268.57 Bn | 260.88 Bn | 11.24 Bn | 4.75 Bn |
| 5 | Pfizer | 156.47 Bn | 144.77 Bn | 10.94 Bn | 4.27 Bn |
| 6 | Sanofi | 52.23 Bn | 44.85 Bn | 10.79 Bn | 1.22 Bn |
| 7 | Revolution Medicines | 43.14 Bn | 43.14 Bn | - | -505.13 Mn |
| 8 | Incyte | 24.83 Bn | 20.29 Bn | 1.57 Bn | 697.90 Mn |
| 9 | United Therapeutics | 21.31 Bn | 18.64 Bn | 683.80 Mn | 330.80 Mn |
| 10 | Karyopharm Therapeutics | 47.44 Mn | -17.67 Mn | 32.35 Mn | -22.53 Mn |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -22.53 Mn |
| Dec 31, 2025 | -17.84 Mn |
| Sep 30, 2025 | -15.22 Mn |
| Jun 30, 2025 | -24.39 Mn |
| Mar 31, 2025 | -33.26 Mn |
| Dec 31, 2024 | -31.28 Mn |
| Sep 30, 2024 | -26.28 Mn |
| Jun 30, 2024 | -28.12 Mn |
| Mar 31, 2024 | -33.76 Mn |
| Dec 31, 2023 | -37.81 Mn |
| Sep 30, 2023 | -31.26 Mn |
| Jun 30, 2023 | -29.57 Mn |
| Mar 31, 2023 | -30.90 Mn |
| Dec 31, 2022 | -33.87 Mn |
| Sep 30, 2022 | -30.84 Mn |
| Jun 30, 2022 | -42.91 Mn |
| Mar 31, 2022 | -34.59 Mn |
| Dec 31, 2021 | 46.96 Mn |
| Sep 30, 2021 | -43.81 Mn |
| Jun 30, 2021 | -49.05 Mn |