Karyopharm Therapeutics KPTI
NASDAQ KPTI
$1.64 -0.05 (-3.02%)
As of: Sep 10, 2026 · 11:08 AM EDT

Karyopharm Therapeutics (KPTI) EBIT (2012 - 2026)

Karyopharm Therapeutics' (KPTI) quarterly EBIT came in at -$22.5 million in Q2 2026, up 7.63% on a YoY basis from -$20.9 million in Q2 2025, and down 26.24% quarter-over-quarter from -$17.8 million in Q4 2025.

Analysis

Karyopharm Therapeutics (KPTI) EBIT (2012 - 2026) Analysis & Trends

Karyopharm Therapeutics (KPTI) has reported EBIT for 15 consecutive years, with -$22.5 million the latest figure, recorded in Q2 2026.

  • For the quarter ending Q2 2026, EBIT rose 7.63% year-over-year to -$22.5 million; the trailing twelve-month figure through Jun 2026 stood at -$80.0 million (up 30.58% YoY), and the FY2025 full-year result was -$90.7 million, up 24.06% from the prior year.
  • EBIT eased to -$22.5 million in Q2 2026 per KPTI's latest filing, from -$17.8 million in the prior quarter.
  • Across five years, EBIT topped out at -$15.2 million in Q3 2025 and bottomed at -$42.9 million in Q2 2022.
  • Historically, EBIT has averaged -$29.7 million across 5 years, with a median of -$30.9 million in 2023.
  • The sharpest annual moves came in 2022 and 2025: EBIT sank 172.12% in 2022, then jumped 42.96% in 2025.
  • Over 5 years, EBIT stood at -$33.9 million in 2022, then fell by 11.63% to -$37.8 million in 2023, then gained by 17.26% to -$31.3 million in 2024, then surged by 42.96% to -$17.8 million in 2025, then fell by 26.24% to -$22.5 million in 2026.
  • According to Business Quant data, EBIT over the past three periods registered -$22.5 million, -$17.8 million, and -$15.2 million for Q2 2026, Q4 2025, and Q3 2025 respectively.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBIT (Qtr)
1 Johnson & Johnson 641.30 Bn 620.54 Bn 17.26 Bn 7.14 Bn
2 AbbVie 446.34 Bn 439.77 Bn 12.70 Bn 6.43 Bn
3 Merck 357.25 Bn 350.11 Bn 12.21 Bn -584.00 Mn
4 Novartis Ag 268.57 Bn 260.88 Bn 11.24 Bn 4.75 Bn
5 Pfizer 156.47 Bn 144.77 Bn 10.94 Bn 4.27 Bn
6 Sanofi 52.23 Bn 44.85 Bn 10.79 Bn 1.22 Bn
7 Revolution Medicines 43.14 Bn 43.14 Bn - -505.13 Mn
8 Incyte 24.83 Bn 20.29 Bn 1.57 Bn 697.90 Mn
9 United Therapeutics 21.31 Bn 18.64 Bn 683.80 Mn 330.80 Mn
10 Karyopharm Therapeutics 47.44 Mn -17.67 Mn 32.35 Mn -22.53 Mn
Historic Data

Historic Data

Download Data
DateValue
Jun 30, 2026 -22.53 Mn
Dec 31, 2025 -17.84 Mn
Sep 30, 2025 -15.22 Mn
Jun 30, 2025 -24.39 Mn
Mar 31, 2025 -33.26 Mn
Dec 31, 2024 -31.28 Mn
Sep 30, 2024 -26.28 Mn
Jun 30, 2024 -28.12 Mn
Mar 31, 2024 -33.76 Mn
Dec 31, 2023 -37.81 Mn
Sep 30, 2023 -31.26 Mn
Jun 30, 2023 -29.57 Mn
Mar 31, 2023 -30.90 Mn
Dec 31, 2022 -33.87 Mn
Sep 30, 2022 -30.84 Mn
Jun 30, 2022 -42.91 Mn
Mar 31, 2022 -34.59 Mn
Dec 31, 2021 46.96 Mn
Sep 30, 2021 -43.81 Mn
Jun 30, 2021 -49.05 Mn