Karyopharm Therapeutics (KPTI) Depreciation and Depletion (2020 - 2025)
Karyopharm Therapeutics' Depreciation and Depletion was $19,000 in Q4 2025, down 76.5% from $81,000 a year earlier and down 84.3% from the prior quarter.
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Analysis
Karyopharm Therapeutics (KPTI) Depreciation and Depletion (2020 - 2025) Analysis & Trends
For FY2025, Depreciation and Depletion at Karyopharm Therapeutics came in at $296,000, down 12.9% from FY2024.
- Depreciation and Depletion has now declined for six consecutive years, with a five-year compound annual growth rate of -21.2% (FY2020 to FY2025).
- In earlier years, Depreciation and Depletion was $340,000 in FY2024 (-35.8%), $530,000 in FY2023 (-14.7%), $621,000 in FY2022 (-21.3%) and $789,000 in FY2021 (-18.8%).
- The Q4 2025 figure marks the lowest quarterly Depreciation and Depletion in data going back to Q1 2020.
- Compared with a year earlier, Depreciation and Depletion was higher in four of the last eight quarters, with an average decline of 13.2%.
- The best year-over-year quarter for Depreciation and Depletion over five years was Q1 2023 (growth of 63.8%); the worst was Q4 2025 (a decline of 76.5%).
- Per Business Quant data, KPTI's Depreciation and Depletion in the three quarters before Q4 2025 was $121,000 (Q3 2025), $78,000 (Q2 2025) and $78,000 (Q1 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Dep. & Depletion (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,076.25 Bn | 1,044.84 Bn | 19.71 Bn | - |
| 2 | Johnson & Johnson | 617.18 Bn | 535.70 Bn | 17.26 Bn | - |
| 3 | AbbVie | 464.58 Bn | 437.73 Bn | 12.70 Bn | 194.00 Mn |
| 4 | Merck | 356.04 Bn | 310.47 Bn | 12.21 Bn | 599.00 Mn |
| 5 | Novartis Ag | 269.07 Bn | 224.94 Bn | 11.24 Bn | - |
| 6 | Astrazeneca | 243.21 Bn | 216.77 Bn | 12.86 Bn | - |
| 7 | Amgen | 217.88 Bn | 173.28 Bn | 7.24 Bn | - |
| 8 | Gilead Sciences | 179.62 Bn | 153.74 Bn | 6.22 Bn | 98.00 Mn |
| 9 | Pfizer | 158.45 Bn | 105.40 Bn | 10.94 Bn | - |
| 10 | Karyopharm Therapeutics | 23.15 Mn | -203.27 Mn | 32.35 Mn | - |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Dec 31, 2025 | 19,000.00 |
| Sep 30, 2025 | 121,000.00 |
| Jun 30, 2025 | 78,000.00 |
| Mar 31, 2025 | 78,000.00 |
| Dec 31, 2024 | 81,000.00 |
| Sep 30, 2024 | 83,000.00 |
| Jun 30, 2024 | 91,000.00 |
| Mar 31, 2024 | 85,000.00 |
| Dec 31, 2023 | 77,000.00 |
| Sep 30, 2023 | 80,000.00 |
| Jun 30, 2023 | 83,000.00 |
| Mar 31, 2023 | 290,000.00 |
| Dec 31, 2022 | 113,000.00 |
| Sep 30, 2022 | 182,000.00 |
| Jun 30, 2022 | 149,000.00 |
| Mar 31, 2022 | 177,000.00 |
| Dec 31, 2021 | 139,000.00 |
| Sep 30, 2021 | 186,000.00 |
| Jun 30, 2021 | 229,000.00 |
| Mar 31, 2021 | 235,000.00 |
API Access
Karyopharm Therapeutics Depreciation and Depletion API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=depreciation-and-depletion&ticker=KPTI&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "depreciation-and-depletion", "ticker": "KPTI", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=depreciation-and-depletion&ticker=KPTI&period=max&api_key=YOUR_API_KEY");
const data = await res.json();