Karyopharm Therapeutics KPTI
NASDAQ KPTI
$1.96 +0.14 (+7.69%)
At close: Aug 21, 2026 · 4:00 PM EDT

Karyopharm Therapeutics (KPTI) Depreciation & Amortization (CF) (2012 - 2025)

Karyopharm Therapeutics' (KPTI) quarterly Depreciation & Amortization (CF) came in at $19000.0 in Q4 2025, down 76.54% YoY from $81000.0 in Q4 2024, and down 84.3% on a QoQ basis from $121000.0 in Q3 2025.

Karyopharm Therapeutics (KPTI) Depreciation & Amortization (CF) (2012 - 2025) Analysis & Trends

Karyopharm Therapeutics (KPTI) has 14 years of Depreciation & Amortization (CF) data on file, last reported at $19000.0 in Q4 2025.

  • Quarterly Depreciation & Amortization (CF) fell 76.54% year-over-year to $19000.0 in Q4 2025, while the trailing twelve-month figure through Dec 2025 was $296000.0 (down 12.94% YoY) and the FY2025 annual result came in at $296000.0, down 12.94% from the prior year.
  • Depreciation & Amortization (CF) declined to $19000.0 in Q4 2025, from $121000.0 in the prior quarter.
  • In the past five years, Depreciation & Amortization (CF) ranged from a high of $290000.0 in Q1 2023 to a low of $19000.0 in Q4 2025.
  • A 5-year average of $128800.0 and a median of $102000.0 in 2022 frame the typical range for Depreciation & Amortization (CF).
  • Annual changes were most pronounced in 2023 — Depreciation & Amortization (CF) surged 63.84% — and 2025, when it plunged 76.54%.
  • Tracing KPTI's Depreciation & Amortization (CF) over 5 years: stood at $139000.0 in 2021, then retreated by 18.71% to $113000.0 in 2022, then tumbled by 31.86% to $77000.0 in 2023, then rose by 5.19% to $81000.0 in 2024, then tumbled by 76.54% to $19000.0 in 2025.
  • The last three Depreciation & Amortization (CF) figures came in at $19000.0 (Q4 2025), $121000.0 (Q3 2025), and $78000.0 (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Depreciation & Amortization (Qtr)
1 Vertex Pharmaceuticals 139.13 Bn 131.28 Bn 2.84 Bn 56.50 Mn
2 Regeneron Pharmaceuticals 85.77 Bn 77.77 Bn 3.93 Bn 123.70 Mn
3 Argenx Se 64.64 Bn 59.46 Bn 1.37 Bn -
4 Moderna 58.29 Bn 53.16 Bn 52.00 Mn -
5 BeOne Medicines 41.92 Bn 36.82 Bn 1.53 Bn 40.52 Mn
6 Alnylam Pharmaceuticals 31.58 Bn 28.28 Bn 992.69 Mn -
7 BioNTech SE 28.12 Bn 9.73 Bn 668.28 Mn 191.83 Mn
8 Insmed 27.39 Bn 26.22 Bn 358.27 Mn -
9 Royalty Pharma 27.27 Bn 26.43 Bn - -
10 Karyopharm Therapeutics 56.72 Mn 56.72 Mn 32.35 Mn -

Historic Data

Download Data
DateValue
Dec 31, 2025 19,000.00
Dec 31, 2025 19,000.00
Sep 30, 2025 121,000.00
Sep 30, 2025 121,000.00
Jun 30, 2025 78,000.00
Jun 30, 2025 78,000.00
Mar 31, 2025 78,000.00
Mar 31, 2025 78,000.00
Dec 31, 2024 81,000.00
Dec 31, 2024 81,000.00
Sep 30, 2024 83,000.00
Sep 30, 2024 83,000.00
Jun 30, 2024 91,000.00
Jun 30, 2024 91,000.00
Mar 31, 2024 85,000.00
Mar 31, 2024 85,000.00
Dec 31, 2023 77,000.00
Dec 31, 2023 77,000.00
Sep 30, 2023 80,000.00
Sep 30, 2023 80,000.00