Karyopharm Therapeutics (KPTI) Depreciation & Amortization (CF) (2012 - 2025)
Karyopharm Therapeutics' (KPTI) quarterly Depreciation & Amortization (CF) came in at $19000.0 in Q4 2025, down 76.54% YoY from $81000.0 in Q4 2024, and down 84.3% on a QoQ basis from $121000.0 in Q3 2025.
Karyopharm Therapeutics (KPTI) Depreciation & Amortization (CF) (2012 - 2025) Analysis & Trends
Karyopharm Therapeutics (KPTI) has 14 years of Depreciation & Amortization (CF) data on file, last reported at $19000.0 in Q4 2025.
- Quarterly Depreciation & Amortization (CF) fell 76.54% year-over-year to $19000.0 in Q4 2025, while the trailing twelve-month figure through Dec 2025 was $296000.0 (down 12.94% YoY) and the FY2025 annual result came in at $296000.0, down 12.94% from the prior year.
- Depreciation & Amortization (CF) declined to $19000.0 in Q4 2025, from $121000.0 in the prior quarter.
- In the past five years, Depreciation & Amortization (CF) ranged from a high of $290000.0 in Q1 2023 to a low of $19000.0 in Q4 2025.
- A 5-year average of $128800.0 and a median of $102000.0 in 2022 frame the typical range for Depreciation & Amortization (CF).
- Annual changes were most pronounced in 2023 — Depreciation & Amortization (CF) surged 63.84% — and 2025, when it plunged 76.54%.
- Tracing KPTI's Depreciation & Amortization (CF) over 5 years: stood at $139000.0 in 2021, then retreated by 18.71% to $113000.0 in 2022, then tumbled by 31.86% to $77000.0 in 2023, then rose by 5.19% to $81000.0 in 2024, then tumbled by 76.54% to $19000.0 in 2025.
- The last three Depreciation & Amortization (CF) figures came in at $19000.0 (Q4 2025), $121000.0 (Q3 2025), and $78000.0 (Q2 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Depreciation & Amortization (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 139.13 Bn | 131.28 Bn | 2.84 Bn | 56.50 Mn |
| 2 | Regeneron Pharmaceuticals | 85.77 Bn | 77.77 Bn | 3.93 Bn | 123.70 Mn |
| 3 | Argenx Se | 64.64 Bn | 59.46 Bn | 1.37 Bn | - |
| 4 | Moderna | 58.29 Bn | 53.16 Bn | 52.00 Mn | - |
| 5 | BeOne Medicines | 41.92 Bn | 36.82 Bn | 1.53 Bn | 40.52 Mn |
| 6 | Alnylam Pharmaceuticals | 31.58 Bn | 28.28 Bn | 992.69 Mn | - |
| 7 | BioNTech SE | 28.12 Bn | 9.73 Bn | 668.28 Mn | 191.83 Mn |
| 8 | Insmed | 27.39 Bn | 26.22 Bn | 358.27 Mn | - |
| 9 | Royalty Pharma | 27.27 Bn | 26.43 Bn | - | - |
| 10 | Karyopharm Therapeutics | 56.72 Mn | 56.72 Mn | 32.35 Mn | - |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 19,000.00 |
| Dec 31, 2025 | 19,000.00 |
| Sep 30, 2025 | 121,000.00 |
| Sep 30, 2025 | 121,000.00 |
| Jun 30, 2025 | 78,000.00 |
| Jun 30, 2025 | 78,000.00 |
| Mar 31, 2025 | 78,000.00 |
| Mar 31, 2025 | 78,000.00 |
| Dec 31, 2024 | 81,000.00 |
| Dec 31, 2024 | 81,000.00 |
| Sep 30, 2024 | 83,000.00 |
| Sep 30, 2024 | 83,000.00 |
| Jun 30, 2024 | 91,000.00 |
| Jun 30, 2024 | 91,000.00 |
| Mar 31, 2024 | 85,000.00 |
| Mar 31, 2024 | 85,000.00 |
| Dec 31, 2023 | 77,000.00 |
| Dec 31, 2023 | 77,000.00 |
| Sep 30, 2023 | 80,000.00 |
| Sep 30, 2023 | 80,000.00 |