Karyopharm Therapeutics (KPTI) Common Equity (2012 - 2025)

Karyopharm Therapeutics (KPTI) reported Common Equity of -$292.9 million for Q4 2025, down 57.47% on a YoY basis from -$688.8 million in Q4 2024, and down 8.79% quarter-over-quarter from -$269.3 million in Q3 2025.

Karyopharm Therapeutics (KPTI) Common Equity (2012 - 2025) Analysis & Trends

Karyopharm Therapeutics has reported Common Equity for 14 years, with the latest figure at -$292.9 million in Q4 2025.

  • For the quarter ending Q4 2025, Common Equity fell 57.47% year-over-year to -$292.9 million; the trailing twelve-month figure through Dec 2025 stood at -$292.9 million (down 57.47% YoY), and the FY2025 full-year result was -$292.9 million, down 57.47% from the prior year.
  • Common Equity for Q4 2025 stood at -$292.9 million, down from -$269.3 million in the prior quarter.
  • The five-year high for Common Equity was -$16.7 million in Q4 2022, with the low at -$292.9 million in Q4 2025.
  • Historically, Common Equity has averaged -$134.6 million across 5 years, with a median of -$129.1 million in 2021.
  • Annual changes were most pronounced in 2022 — Common Equity surged 79.09% — and 2023, when it plunged 717.76%.
  • Karyopharm Therapeutics' Common Equity stood at -$79.7 million in 2021, then surged by 79.09% to -$16.7 million in 2022, then sank by 717.76% to -$136.2 million in 2023, then tumbled by 36.57% to -$186.0 million in 2024, then slumped by 57.47% to -$292.9 million in 2025.
  • The last three Common Equity figures came in at -$292.9 million (Q4 2025), -$269.3 million (Q3 2025), and -$238.9 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Common Equity (Qtr)
1 Alterity Therapeutics 762,369.55 Bn 762,369.51 Bn - 35.63 Mn
2 Belite Bio 55,096.00 Bn 55,096.00 Bn - -
3 Quantum Biopharma 17,755.80 Bn 17,755.79 Bn - -1.42 Mn
4 Legend Biotech 3,486.00 Bn 3,485.71 Bn 242.10 Mn -
5 Akari Therapeutics 1,737.42 Bn 1,737.41 Bn - 14.38 Mn
6 Evaxion A 1,551.28 Bn 1,551.26 Bn - 13.21 Mn
7 Psyence Biomedical 227.32 Bn 227.31 Bn - 11.87 Mn
8 Vertex Pharmaceuticals 110.84 Bn 103.59 Bn 2.59 Bn 19.36 Bn
9 Abivax 91.71 Bn 91.71 Bn - -
10 Karyopharm Therapeutics 95.31 Mn 31.56 Mn 32.74 Mn -292.93 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 -292.93 Mn
Sep 30, 2025 -269.26 Mn
Jun 30, 2025 -238.93 Mn
Mar 31, 2025 -205.88 Mn
Dec 31, 2024 -186.02 Mn
Sep 30, 2024 -159.65 Mn
Jun 30, 2024 -132.14 Mn
Mar 31, 2024 -168.96 Mn
Dec 31, 2023 -136.21 Mn
Sep 30, 2023 -100.40 Mn
Jun 30, 2023 -71.25 Mn
Mar 31, 2023 -45.17 Mn
Dec 31, 2022 -16.66 Mn
Sep 30, 2022 -140.28 Mn
Jun 30, 2022 -116.34 Mn
Mar 31, 2022 -83.08 Mn
Dec 31, 2021 -79.67 Mn
Sep 30, 2021 -125.98 Mn
Jun 30, 2021 -83.13 Mn
Mar 31, 2021 -39.64 Mn