Karyopharm Therapeutics (KPTI) Change in Acquisitions & Divestments (2015 - 2025)

Karyopharm Therapeutics (KPTI) reported Change in Acquisitions & Divestments of $5.0 million for Q4 2025, down 69.23% on a YoY basis from $16.2 million in Q4 2024, and up 4.06% quarter-over-quarter from $4.8 million in Q3 2025.

Karyopharm Therapeutics (KPTI) Change in Acquisitions & Divestments (2015 - 2025) Analysis & Trends

Karyopharm Therapeutics has reported Change in Acquisitions & Divestments for 11 years, with the latest figure at $5.0 million in Q4 2025.

  • For the quarter ending Q4 2025, Change in Acquisitions & Divestments fell 69.23% year-over-year to $5.0 million; the trailing twelve-month figure through Dec 2025 stood at $43.4 million (down 71.91% YoY), and the FY2025 full-year result was $43.4 million, down 71.91% from the prior year.
  • Change in Acquisitions & Divestments for Q4 2025 stood at $5.0 million, up from $4.8 million in the prior quarter.
  • The five-year high for Change in Acquisitions & Divestments was $69.0 million in Q1 2021, with the low at $4.8 million in Q3 2025.
  • Historically, Change in Acquisitions & Divestments has averaged $34.0 million across 5 years, with a median of $31.1 million in 2021.
  • Annual changes were most pronounced in 2023 — Change in Acquisitions & Divestments soared 113.38% — and 2025, when it plunged 83.01%.
  • Karyopharm Therapeutics' Change in Acquisitions & Divestments stood at $30.5 million in 2021, then increased by 4.34% to $31.8 million in 2022, then surged by 36.49% to $43.4 million in 2023, then tumbled by 62.56% to $16.2 million in 2024, then tumbled by 69.23% to $5.0 million in 2025.
  • The last three Change in Acquisitions & Divestments figures came in at $5.0 million (Q4 2025), $4.8 million (Q3 2025), and $18.3 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr)
1 Alterity Therapeutics 762,369.55 Bn 762,369.51 Bn -
2 Belite Bio 55,096.00 Bn 55,096.00 Bn -
3 Quantum Biopharma 17,755.80 Bn 17,755.79 Bn -
4 Legend Biotech 3,486.00 Bn 3,485.71 Bn 242.10 Mn
5 Akari Therapeutics 1,737.42 Bn 1,737.41 Bn -
6 Evaxion A 1,551.28 Bn 1,551.26 Bn -
7 Psyence Biomedical 227.32 Bn 227.31 Bn -
8 Vertex Pharmaceuticals 110.84 Bn 103.59 Bn 2.59 Bn
9 Abivax 91.71 Bn 91.71 Bn -
10 Karyopharm Therapeutics 95.31 Mn 31.56 Mn 32.74 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 5.00 Mn
Dec 31, 2025 5.00 Mn
Sep 30, 2025 4.81 Mn
Sep 30, 2025 4.81 Mn
Jun 30, 2025 18.29 Mn
Jun 30, 2025 18.29 Mn
Mar 31, 2025 15.29 Mn
Mar 31, 2025 15.29 Mn
Dec 31, 2024 16.25 Mn
Dec 31, 2024 16.25 Mn
Sep 30, 2024 28.28 Mn
Sep 30, 2024 28.28 Mn
Jun 30, 2024 56.17 Mn
Jun 30, 2024 56.17 Mn
Mar 31, 2024 53.74 Mn
Mar 31, 2024 53.74 Mn
Dec 31, 2023 43.40 Mn
Dec 31, 2023 43.40 Mn
Sep 30, 2023 38.38 Mn
Sep 30, 2023 38.38 Mn