Karyopharm Therapeutics (KPTI) Change in Acquisitions & Divestments (2015 - 2025)
Karyopharm Therapeutics' (KPTI) quarterly Change in Acquisitions & Divestments came in at $5.0 million in Q4 2025, down 69.23% YoY from $16.2 million in Q4 2024, and up 4.06% on a QoQ basis from $4.8 million in Q3 2025.
Karyopharm Therapeutics (KPTI) Change in Acquisitions & Divestments (2015 - 2025) Analysis & Trends
Karyopharm Therapeutics (KPTI) has 11 years of Change in Acquisitions & Divestments data on file, last reported at $5.0 million in Q4 2025.
- Quarterly Change in Acquisitions & Divestments fell 69.23% year-over-year to $5.0 million in Q4 2025, while the trailing twelve-month figure through Dec 2025 was $43.4 million (down 71.91% YoY) and the FY2025 annual result came in at $43.4 million, down 71.91% from the prior year.
- Change in Acquisitions & Divestments improved to $5.0 million in Q4 2025, from $4.8 million in the prior quarter.
- In the past five years, Change in Acquisitions & Divestments ranged from a high of $69.0 million in Q1 2021 to a low of $4.8 million in Q3 2025.
- A 5-year average of $34.0 million and a median of $31.1 million in 2021 frame the typical range for Change in Acquisitions & Divestments.
- Annual changes were most pronounced in 2023 — Change in Acquisitions & Divestments soared 113.38% — and 2025, when it plunged 83.01%.
- Tracing KPTI's Change in Acquisitions & Divestments over 5 years: stood at $30.5 million in 2021, then increased by 4.34% to $31.8 million in 2022, then surged by 36.49% to $43.4 million in 2023, then tumbled by 62.56% to $16.2 million in 2024, then tumbled by 69.23% to $5.0 million in 2025.
- The last three Change in Acquisitions & Divestments figures came in at $5.0 million (Q4 2025), $4.8 million (Q3 2025), and $18.3 million (Q2 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) |
|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 139.13 Bn | 131.28 Bn | 2.84 Bn |
| 2 | Regeneron Pharmaceuticals | 85.77 Bn | 77.77 Bn | 3.93 Bn |
| 3 | Argenx Se | 64.64 Bn | 59.46 Bn | 1.37 Bn |
| 4 | Moderna | 58.29 Bn | 53.16 Bn | 52.00 Mn |
| 5 | BeOne Medicines | 41.92 Bn | 36.82 Bn | 1.53 Bn |
| 6 | Alnylam Pharmaceuticals | 31.58 Bn | 28.28 Bn | 992.69 Mn |
| 7 | BioNTech SE | 28.12 Bn | 9.73 Bn | 668.28 Mn |
| 8 | Insmed | 27.39 Bn | 26.22 Bn | 358.27 Mn |
| 9 | Royalty Pharma | 27.27 Bn | 26.43 Bn | - |
| 10 | Karyopharm Therapeutics | 56.72 Mn | 56.72 Mn | 32.35 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 5.00 Mn |
| Dec 31, 2025 | 5.00 Mn |
| Sep 30, 2025 | 4.81 Mn |
| Sep 30, 2025 | 4.81 Mn |
| Jun 30, 2025 | 18.29 Mn |
| Jun 30, 2025 | 18.29 Mn |
| Mar 31, 2025 | 15.29 Mn |
| Mar 31, 2025 | 15.29 Mn |
| Dec 31, 2024 | 16.25 Mn |
| Dec 31, 2024 | 16.25 Mn |
| Sep 30, 2024 | 28.28 Mn |
| Sep 30, 2024 | 28.28 Mn |
| Jun 30, 2024 | 56.17 Mn |
| Jun 30, 2024 | 56.17 Mn |
| Mar 31, 2024 | 53.74 Mn |
| Mar 31, 2024 | 53.74 Mn |
| Dec 31, 2023 | 43.40 Mn |
| Dec 31, 2023 | 43.40 Mn |
| Sep 30, 2023 | 38.38 Mn |
| Sep 30, 2023 | 38.38 Mn |