Karyopharm Therapeutics KPTI
NASDAQ KPTI
$1.96 +0.14 (+7.69%)
At close: Aug 21, 2026 · 4:00 PM EDT

Karyopharm Therapeutics (KPTI) Change in Accured Expenses (2012 - 2025)

Karyopharm Therapeutics' (KPTI) quarterly Change in Accured Expenses came in at $1.4 million in Q4 2025, down 77.67% YoY from $6.5 million in Q4 2024, and down 84.75% on a QoQ basis from $9.5 million in Q3 2025.

Karyopharm Therapeutics (KPTI) Change in Accured Expenses (2012 - 2025) Analysis & Trends

Karyopharm Therapeutics (KPTI) has 14 years of Change in Accured Expenses data on file, last reported at $1.4 million in Q4 2025.

  • Quarterly Change in Accured Expenses fell 77.67% year-over-year to $1.4 million in Q4 2025, while the trailing twelve-month figure through Dec 2025 was $19.1 million (up 353.77% YoY) and the FY2025 annual result came in at $19.1 million, up 353.77% from the prior year.
  • Change in Accured Expenses retreated to $1.4 million in Q4 2025, from $9.5 million in the prior quarter.
  • In the past five years, Change in Accured Expenses ranged from a high of $12.1 million in Q3 2021 to a low of -$9.4 million in Q1 2023.
  • A 5-year average of $1.7 million and a median of $2.3 million in 2022 frame the typical range for Change in Accured Expenses.
  • Annual changes were most pronounced in 2022 — Change in Accured Expenses tumbled 373.51% — and 2025, when it jumped 14957.89%.
  • Tracing KPTI's Change in Accured Expenses over 5 years: stood at $3.7 million in 2021, then plunged by 43.34% to $2.1 million in 2022, then soared by 129.16% to $4.8 million in 2023, then jumped by 35.08% to $6.5 million in 2024, then sank by 77.67% to $1.4 million in 2025.
  • The last three Change in Accured Expenses figures came in at $1.4 million (Q4 2025), $9.5 million (Q3 2025), and $8.6 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Change in Accured Expenses (Qtr)
1 Vertex Pharmaceuticals 139.13 Bn 131.28 Bn 2.84 Bn 222.50 Mn
2 Regeneron Pharmaceuticals 85.77 Bn 77.77 Bn 3.93 Bn 492.70 Mn
3 Argenx Se 64.64 Bn 59.46 Bn 1.37 Bn -
4 Moderna 58.29 Bn 53.16 Bn 52.00 Mn 11.00 Mn
5 BeOne Medicines 41.92 Bn 36.82 Bn 1.53 Bn 212.44 Mn
6 Alnylam Pharmaceuticals 31.58 Bn 28.28 Bn 992.69 Mn 61.62 Mn
7 BioNTech SE 28.12 Bn 9.73 Bn 668.28 Mn -
8 Insmed 27.39 Bn 26.22 Bn 358.27 Mn 68.82 Mn
9 Royalty Pharma 27.27 Bn 26.43 Bn - -
10 Karyopharm Therapeutics 56.72 Mn 56.72 Mn 32.35 Mn -

Historic Data

Download Data
DateValue
Dec 31, 2025 1.44 Mn
Dec 31, 2025 1.44 Mn
Sep 30, 2025 9.45 Mn
Sep 30, 2025 9.45 Mn
Jun 30, 2025 8.58 Mn
Jun 30, 2025 8.58 Mn
Mar 31, 2025 -412,000.00
Mar 31, 2025 -412,000.00
Dec 31, 2024 6.45 Mn
Dec 31, 2024 6.45 Mn
Sep 30, 2024 2.55 Mn
Sep 30, 2024 2.55 Mn
Jun 30, 2024 57,000.00
Jun 30, 2024 57,000.00
Mar 31, 2024 -4.86 Mn
Mar 31, 2024 -4.86 Mn
Dec 31, 2023 4.78 Mn
Dec 31, 2023 4.78 Mn
Sep 30, 2023 3.30 Mn
Sep 30, 2023 3.30 Mn