Karyopharm Therapeutics (KPTI) Change in Accured Expenses (2012 - 2025)
Karyopharm Therapeutics' (KPTI) quarterly Change in Accured Expenses came in at $1.4 million in Q4 2025, down 77.67% YoY from $6.5 million in Q4 2024, and down 84.75% on a QoQ basis from $9.5 million in Q3 2025.
Karyopharm Therapeutics (KPTI) Change in Accured Expenses (2012 - 2025) Analysis & Trends
Karyopharm Therapeutics (KPTI) has 14 years of Change in Accured Expenses data on file, last reported at $1.4 million in Q4 2025.
- Quarterly Change in Accured Expenses fell 77.67% year-over-year to $1.4 million in Q4 2025, while the trailing twelve-month figure through Dec 2025 was $19.1 million (up 353.77% YoY) and the FY2025 annual result came in at $19.1 million, up 353.77% from the prior year.
- Change in Accured Expenses retreated to $1.4 million in Q4 2025, from $9.5 million in the prior quarter.
- In the past five years, Change in Accured Expenses ranged from a high of $12.1 million in Q3 2021 to a low of -$9.4 million in Q1 2023.
- A 5-year average of $1.7 million and a median of $2.3 million in 2022 frame the typical range for Change in Accured Expenses.
- Annual changes were most pronounced in 2022 — Change in Accured Expenses tumbled 373.51% — and 2025, when it jumped 14957.89%.
- Tracing KPTI's Change in Accured Expenses over 5 years: stood at $3.7 million in 2021, then plunged by 43.34% to $2.1 million in 2022, then soared by 129.16% to $4.8 million in 2023, then jumped by 35.08% to $6.5 million in 2024, then sank by 77.67% to $1.4 million in 2025.
- The last three Change in Accured Expenses figures came in at $1.4 million (Q4 2025), $9.5 million (Q3 2025), and $8.6 million (Q2 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Change in Accured Expenses (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 139.13 Bn | 131.28 Bn | 2.84 Bn | 222.50 Mn |
| 2 | Regeneron Pharmaceuticals | 85.77 Bn | 77.77 Bn | 3.93 Bn | 492.70 Mn |
| 3 | Argenx Se | 64.64 Bn | 59.46 Bn | 1.37 Bn | - |
| 4 | Moderna | 58.29 Bn | 53.16 Bn | 52.00 Mn | 11.00 Mn |
| 5 | BeOne Medicines | 41.92 Bn | 36.82 Bn | 1.53 Bn | 212.44 Mn |
| 6 | Alnylam Pharmaceuticals | 31.58 Bn | 28.28 Bn | 992.69 Mn | 61.62 Mn |
| 7 | BioNTech SE | 28.12 Bn | 9.73 Bn | 668.28 Mn | - |
| 8 | Insmed | 27.39 Bn | 26.22 Bn | 358.27 Mn | 68.82 Mn |
| 9 | Royalty Pharma | 27.27 Bn | 26.43 Bn | - | - |
| 10 | Karyopharm Therapeutics | 56.72 Mn | 56.72 Mn | 32.35 Mn | - |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 1.44 Mn |
| Dec 31, 2025 | 1.44 Mn |
| Sep 30, 2025 | 9.45 Mn |
| Sep 30, 2025 | 9.45 Mn |
| Jun 30, 2025 | 8.58 Mn |
| Jun 30, 2025 | 8.58 Mn |
| Mar 31, 2025 | -412,000.00 |
| Mar 31, 2025 | -412,000.00 |
| Dec 31, 2024 | 6.45 Mn |
| Dec 31, 2024 | 6.45 Mn |
| Sep 30, 2024 | 2.55 Mn |
| Sep 30, 2024 | 2.55 Mn |
| Jun 30, 2024 | 57,000.00 |
| Jun 30, 2024 | 57,000.00 |
| Mar 31, 2024 | -4.86 Mn |
| Mar 31, 2024 | -4.86 Mn |
| Dec 31, 2023 | 4.78 Mn |
| Dec 31, 2023 | 4.78 Mn |
| Sep 30, 2023 | 3.30 Mn |
| Sep 30, 2023 | 3.30 Mn |