Karyopharm Therapeutics (KPTI) Change in Accured Expenses (2012 - 2025)
Karyopharm Therapeutics (KPTI) reported Change in Accured Expenses of $1.4 million for Q4 2025, down 77.67% on a YoY basis from $6.5 million in Q4 2024, and down 84.75% quarter-over-quarter from $9.5 million in Q3 2025.
Karyopharm Therapeutics (KPTI) Change in Accured Expenses (2012 - 2025) Analysis & Trends
Karyopharm Therapeutics has reported Change in Accured Expenses for 14 years, with the latest figure at $1.4 million in Q4 2025.
- For the quarter ending Q4 2025, Change in Accured Expenses fell 77.67% year-over-year to $1.4 million; the trailing twelve-month figure through Dec 2025 stood at $19.1 million (up 353.77% YoY), and the FY2025 full-year result was $19.1 million, up 353.77% from the prior year.
- Change in Accured Expenses for Q4 2025 stood at $1.4 million, down from $9.5 million in the prior quarter.
- The five-year high for Change in Accured Expenses was $12.1 million in Q3 2021, with the low at -$9.4 million in Q1 2023.
- Historically, Change in Accured Expenses has averaged $1.7 million across 5 years, with a median of $2.3 million in 2022.
- Annual changes were most pronounced in 2022 — Change in Accured Expenses tumbled 373.51% — and 2025, when it jumped 14957.89%.
- Karyopharm Therapeutics' Change in Accured Expenses stood at $3.7 million in 2021, then plunged by 43.34% to $2.1 million in 2022, then soared by 129.16% to $4.8 million in 2023, then jumped by 35.08% to $6.5 million in 2024, then sank by 77.67% to $1.4 million in 2025.
- The last three Change in Accured Expenses figures came in at $1.4 million (Q4 2025), $9.5 million (Q3 2025), and $8.6 million (Q2 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Change Accured Exp. (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 762,369.55 Bn | 762,369.51 Bn | - | - |
| 2 | Belite Bio | 55,096.00 Bn | 55,096.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,755.80 Bn | 17,755.79 Bn | - | - |
| 4 | Legend Biotech | 3,486.00 Bn | 3,485.71 Bn | 242.10 Mn | - |
| 5 | Akari Therapeutics | 1,737.42 Bn | 1,737.41 Bn | - | 931,000.00 |
| 6 | Evaxion A | 1,551.28 Bn | 1,551.26 Bn | - | - |
| 7 | Psyence Biomedical | 227.32 Bn | 227.31 Bn | - | 644,700.00 |
| 8 | Vertex Pharmaceuticals | 110.84 Bn | 103.59 Bn | 2.59 Bn | 70.50 Mn |
| 9 | Abivax | 91.71 Bn | 91.71 Bn | - | - |
| 10 | Karyopharm Therapeutics | 95.31 Mn | 31.56 Mn | 32.74 Mn | 1.44 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 1.44 Mn |
| Dec 31, 2025 | 1.44 Mn |
| Sep 30, 2025 | 9.45 Mn |
| Sep 30, 2025 | 9.45 Mn |
| Jun 30, 2025 | 8.58 Mn |
| Jun 30, 2025 | 8.58 Mn |
| Mar 31, 2025 | -412,000.00 |
| Mar 31, 2025 | -412,000.00 |
| Dec 31, 2024 | 6.45 Mn |
| Dec 31, 2024 | 6.45 Mn |
| Sep 30, 2024 | 2.55 Mn |
| Sep 30, 2024 | 2.55 Mn |
| Jun 30, 2024 | 57,000.00 |
| Jun 30, 2024 | 57,000.00 |
| Mar 31, 2024 | -4.86 Mn |
| Mar 31, 2024 | -4.86 Mn |
| Dec 31, 2023 | 4.78 Mn |
| Dec 31, 2023 | 4.78 Mn |
| Sep 30, 2023 | 3.30 Mn |
| Sep 30, 2023 | 3.30 Mn |