Karyopharm Therapeutics KPTI
NASDAQ KPTI
$1.96 +0.14 (+7.69%)
At close: Aug 21, 2026 · 4:00 PM EDT

Karyopharm Therapeutics (KPTI) Cash from Investing Activities (2013 - 2025)

Karyopharm Therapeutics' (KPTI) quarterly Cash from Investing Activities came in at $5.0 million in Q4 2025, down 66.21% YoY from $14.8 million in Q4 2024, and up 4.06% on a QoQ basis from $4.8 million in Q3 2025.

Karyopharm Therapeutics (KPTI) Cash from Investing Activities (2013 - 2025) Analysis & Trends

Karyopharm Therapeutics (KPTI) has 13 years of Cash from Investing Activities data on file, last reported at $5.0 million in Q4 2025.

  • Quarterly Cash from Investing Activities fell 66.21% year-over-year to $5.0 million in Q4 2025, while the trailing twelve-month figure through Dec 2025 was $43.4 million (down 54.57% YoY) and the FY2025 annual result came in at $43.4 million, down 54.57% from the prior year.
  • Cash from Investing Activities improved to $5.0 million in Q4 2025, from $4.8 million in the prior quarter.
  • In the past five years, Cash from Investing Activities ranged from a high of $51.3 million in Q2 2024 to a low of -$65.3 million in Q4 2022.
  • A 5-year average of $9.2 million and a median of $15.0 million in 2024 frame the typical range for Cash from Investing Activities.
  • Annual changes were most pronounced in 2022 — Cash from Investing Activities tumbled 312.21% — and 2024, when it jumped 197.25%.
  • Tracing KPTI's Cash from Investing Activities over 5 years: stood at $30.8 million in 2021, then tumbled by 312.21% to -$65.3 million in 2022, then soared by 141.11% to $26.8 million in 2023, then tumbled by 44.88% to $14.8 million in 2024, then tumbled by 66.21% to $5.0 million in 2025.
  • The last three Cash from Investing Activities figures came in at $5.0 million (Q4 2025), $4.8 million (Q3 2025), and $18.3 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Cash from Investing Activities (Qtr)
1 Vertex Pharmaceuticals 139.13 Bn 131.28 Bn 2.84 Bn -45.80 Mn
2 Regeneron Pharmaceuticals 85.77 Bn 77.77 Bn 3.93 Bn -92.70 Mn
3 Argenx Se 64.64 Bn 59.46 Bn 1.37 Bn -
4 Moderna 58.29 Bn 53.16 Bn 52.00 Mn 329.00 Mn
5 BeOne Medicines 41.92 Bn 36.82 Bn 1.53 Bn -49.35 Mn
6 Alnylam Pharmaceuticals 31.58 Bn 28.28 Bn 992.69 Mn -363.46 Mn
7 BioNTech SE 28.12 Bn 9.73 Bn 668.28 Mn -3.17 Bn
8 Insmed 27.39 Bn 26.22 Bn 358.27 Mn 24.51 Mn
9 Royalty Pharma 27.27 Bn 26.43 Bn - -229.72 Mn
10 Karyopharm Therapeutics 56.72 Mn 56.72 Mn 32.35 Mn -

Historic Data

Download Data
DateValue
Dec 31, 2025 5.00 Mn
Dec 31, 2025 5.00 Mn
Sep 30, 2025 4.81 Mn
Sep 30, 2025 4.81 Mn
Jun 30, 2025 18.29 Mn
Jun 30, 2025 18.29 Mn
Mar 31, 2025 15.29 Mn
Mar 31, 2025 15.29 Mn
Dec 31, 2024 14.80 Mn
Dec 31, 2024 14.80 Mn
Sep 30, 2024 7.47 Mn
Sep 30, 2024 7.47 Mn
Jun 30, 2024 51.26 Mn
Jun 30, 2024 51.26 Mn
Mar 31, 2024 21.94 Mn
Mar 31, 2024 21.94 Mn
Dec 31, 2023 26.84 Mn
Dec 31, 2023 26.84 Mn
Sep 30, 2023 -7.69 Mn
Sep 30, 2023 -7.69 Mn