Karyopharm Therapeutics (KPTI) Cash from Investing Activities (2013 - 2025)

Karyopharm Therapeutics (KPTI) reported Cash from Investing Activities of $5.0 million for Q4 2025, down 66.21% on a YoY basis from $14.8 million in Q4 2024, and up 4.06% quarter-over-quarter from $4.8 million in Q3 2025.

Karyopharm Therapeutics (KPTI) Cash from Investing Activities (2013 - 2025) Analysis & Trends

Karyopharm Therapeutics has reported Cash from Investing Activities for 13 years, with the latest figure at $5.0 million in Q4 2025.

  • For the quarter ending Q4 2025, Cash from Investing Activities fell 66.21% year-over-year to $5.0 million; the trailing twelve-month figure through Dec 2025 stood at $43.4 million (down 54.57% YoY), and the FY2025 full-year result was $43.4 million, down 54.57% from the prior year.
  • Cash from Investing Activities for Q4 2025 stood at $5.0 million, up from $4.8 million in the prior quarter.
  • The five-year high for Cash from Investing Activities was $51.3 million in Q2 2024, with the low at -$65.3 million in Q4 2022.
  • Historically, Cash from Investing Activities has averaged $9.2 million across 5 years, with a median of $15.0 million in 2024.
  • Annual changes were most pronounced in 2022 — Cash from Investing Activities tumbled 312.21% — and 2024, when it jumped 197.25%.
  • Karyopharm Therapeutics' Cash from Investing Activities stood at $30.8 million in 2021, then tumbled by 312.21% to -$65.3 million in 2022, then soared by 141.11% to $26.8 million in 2023, then tumbled by 44.88% to $14.8 million in 2024, then tumbled by 66.21% to $5.0 million in 2025.
  • The last three Cash from Investing Activities figures came in at $5.0 million (Q4 2025), $4.8 million (Q3 2025), and $18.3 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Cash from Investing (Qtr)
1 Alterity Therapeutics 762,369.55 Bn 762,369.51 Bn - -
2 Belite Bio 55,096.00 Bn 55,096.00 Bn - -
3 Quantum Biopharma 17,755.80 Bn 17,755.79 Bn - -2.89 Mn
4 Legend Biotech 3,486.00 Bn 3,485.71 Bn 242.10 Mn 638.50 Mn
5 Akari Therapeutics 1,737.42 Bn 1,737.41 Bn - -
6 Evaxion A 1,551.28 Bn 1,551.26 Bn - -
7 Psyence Biomedical 227.32 Bn 227.31 Bn - -
8 Vertex Pharmaceuticals 110.84 Bn 103.59 Bn 2.59 Bn -431.90 Mn
9 Abivax 91.71 Bn 91.71 Bn - 579,519.10
10 Karyopharm Therapeutics 95.31 Mn 31.56 Mn 32.74 Mn 5.00 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 5.00 Mn
Dec 31, 2025 5.00 Mn
Sep 30, 2025 4.81 Mn
Sep 30, 2025 4.81 Mn
Jun 30, 2025 18.29 Mn
Jun 30, 2025 18.29 Mn
Mar 31, 2025 15.29 Mn
Mar 31, 2025 15.29 Mn
Dec 31, 2024 14.80 Mn
Dec 31, 2024 14.80 Mn
Sep 30, 2024 7.47 Mn
Sep 30, 2024 7.47 Mn
Jun 30, 2024 51.26 Mn
Jun 30, 2024 51.26 Mn
Mar 31, 2024 21.94 Mn
Mar 31, 2024 21.94 Mn
Dec 31, 2023 26.84 Mn
Dec 31, 2023 26.84 Mn
Sep 30, 2023 -7.69 Mn
Sep 30, 2023 -7.69 Mn