Karyopharm Therapeutics KPTI
NASDAQ KPTI
$1.96 +0.14 (+7.69%)
At close: Aug 21, 2026 · 4:00 PM EDT

Karyopharm Therapeutics (KPTI) Cash & Current Investments (2012 - 2026)

Karyopharm Therapeutics' (KPTI) quarterly Cash & Current Investments came in at $50.9 million in Q4 2025, down 64.76% YoY from $144.5 million in Q4 2024, and up 16.98% on a QoQ basis from $43.5 million in Q3 2025.

Karyopharm Therapeutics (KPTI) Cash & Current Investments (2012 - 2026) Analysis & Trends

Karyopharm Therapeutics (KPTI) has 14 years of Cash & Current Investments data on file, last reported at $50.9 million in Q4 2025.

  • Quarterly Cash & Current Investments fell 64.76% year-over-year to $50.9 million in Q4 2025, while the trailing twelve-month figure through Dec 2025 was $50.9 million (down 64.76% YoY) and the FY2025 annual result came in at $50.9 million, down 64.76% from the prior year.
  • Cash & Current Investments rose to $50.9 million in Q4 2025, from $43.5 million in the prior quarter.
  • In the past five years, Cash & Current Investments ranged from a high of $278.0 million in Q4 2022 to a low of $43.5 million in Q3 2025.
  • A 5-year average of $139.0 million and a median of $146.5 million in 2022 frame the typical range for Cash & Current Investments.
  • Annual changes were most pronounced in 2021 — Cash & Current Investments sank 82.14% — and 2022, when it soared 524.57%.
  • Tracing KPTI's Cash & Current Investments over 5 years: stood at $44.5 million in 2021, then soared by 524.57% to $278.0 million in 2022, then slumped by 31.13% to $191.4 million in 2023, then fell by 24.5% to $144.5 million in 2024, then plunged by 64.76% to $50.9 million in 2025.
  • The last three Cash & Current Investments figures came in at $50.9 million (Q4 2025), $43.5 million (Q3 2025), and $47.9 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Cash & Current Investments (Qtr)
1 Vertex Pharmaceuticals 139.13 Bn 131.28 Bn 2.84 Bn 7.85 Bn
2 Regeneron Pharmaceuticals 85.77 Bn 77.77 Bn 3.93 Bn 7.99 Bn
3 Argenx Se 64.64 Bn 59.46 Bn 1.37 Bn 5.18 Bn
4 Moderna 58.29 Bn 53.16 Bn 52.00 Mn 5.14 Bn
5 BeOne Medicines 41.92 Bn 36.82 Bn 1.53 Bn 5.10 Bn
6 Alnylam Pharmaceuticals 31.58 Bn 28.28 Bn 992.69 Mn 3.31 Bn
7 BioNTech SE 28.12 Bn 9.73 Bn 668.28 Mn 18.39 Bn
8 Insmed 27.39 Bn 26.22 Bn 358.27 Mn 1.16 Bn
9 Royalty Pharma 27.27 Bn 26.43 Bn - 836.99 Mn
10 Karyopharm Therapeutics 56.72 Mn 56.72 Mn 32.35 Mn -

Historic Data

Download Data
DateValue
Jun 30, 2026 65.11 Mn
Dec 31, 2025 50.94 Mn
Sep 30, 2025 43.55 Mn
Jun 30, 2025 47.88 Mn
Mar 31, 2025 85.43 Mn
Dec 31, 2024 144.53 Mn
Sep 30, 2024 133.53 Mn
Jun 30, 2024 152.12 Mn
Mar 31, 2024 148.58 Mn
Dec 31, 2023 191.44 Mn
Sep 30, 2023 165.21 Mn
Jun 30, 2023 236.77 Mn
Mar 31, 2023 177.17 Mn
Dec 31, 2022 277.97 Mn
Sep 30, 2022 148.38 Mn
Jun 30, 2022 89.74 Mn
Mar 31, 2022 205.31 Mn
Dec 31, 2021 44.51 Mn
Sep 30, 2021 204.21 Mn
Jun 30, 2021 95.34 Mn