Karyopharm Therapeutics KPTI
NASDAQ KPTI
$1.96 +0.14 (+7.69%)
At close: Aug 21, 2026 · 4:00 PM EDT

Karyopharm Therapeutics (KPTI) Accumulated Expenses (2012 - 2026)

Karyopharm Therapeutics' (KPTI) quarterly Accumulated Expenses came in at $4.4 million in Q4 2025, down 68.53% YoY from $13.9 million in Q4 2024, and down 93.4% on a QoQ basis from $66.3 million in Q3 2025.

Karyopharm Therapeutics (KPTI) Accumulated Expenses (2012 - 2026) Analysis & Trends

Karyopharm Therapeutics (KPTI) has 14 years of Accumulated Expenses data on file, last reported at $4.4 million in Q4 2025.

  • Quarterly Accumulated Expenses fell 68.53% year-over-year to $4.4 million in Q4 2025, while the trailing twelve-month figure through Dec 2025 was $4.4 million (down 68.53% YoY) and the FY2025 annual result came in at $4.4 million, down 68.53% from the prior year.
  • Accumulated Expenses retreated to $4.4 million in Q4 2025, from $66.3 million in the prior quarter.
  • In the past five years, Accumulated Expenses ranged from a high of $66.3 million in Q3 2025 to a low of $4.4 million in Q4 2025.
  • A 5-year average of $45.3 million and a median of $54.0 million in 2021 frame the typical range for Accumulated Expenses.
  • Annual changes were most pronounced in 2021 — Accumulated Expenses surged 38.86% — and 2025, when it sank 68.53%.
  • Tracing KPTI's Accumulated Expenses over 5 years: stood at $22.0 million in 2021, then tumbled by 46.89% to $11.7 million in 2022, then increased by 15.26% to $13.5 million in 2023, then advanced by 3.43% to $13.9 million in 2024, then tumbled by 68.53% to $4.4 million in 2025.
  • The last three Accumulated Expenses figures came in at $4.4 million (Q4 2025), $66.3 million (Q3 2025), and $62.9 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr)
1 Vertex Pharmaceuticals 139.13 Bn 131.28 Bn 2.84 Bn
2 Regeneron Pharmaceuticals 85.77 Bn 77.77 Bn 3.93 Bn
3 Argenx Se 64.64 Bn 59.46 Bn 1.37 Bn
4 Moderna 58.29 Bn 53.16 Bn 52.00 Mn
5 BeOne Medicines 41.92 Bn 36.82 Bn 1.53 Bn
6 Alnylam Pharmaceuticals 31.58 Bn 28.28 Bn 992.69 Mn
7 BioNTech SE 28.12 Bn 9.73 Bn 668.28 Mn
8 Insmed 27.39 Bn 26.22 Bn 358.27 Mn
9 Royalty Pharma 27.27 Bn 26.43 Bn -
10 Karyopharm Therapeutics 56.72 Mn 56.72 Mn 32.35 Mn

Historic Data

Download Data
DateValue
Jun 30, 2026 78.80 Mn
Dec 31, 2025 4.38 Mn
Sep 30, 2025 66.33 Mn
Jun 30, 2025 62.93 Mn
Mar 31, 2025 57.17 Mn
Dec 31, 2024 13.92 Mn
Sep 30, 2024 50.11 Mn
Jun 30, 2024 49.81 Mn
Mar 31, 2024 54.85 Mn
Dec 31, 2023 13.45 Mn
Sep 30, 2023 55.71 Mn
Jun 30, 2023 51.81 Mn
Mar 31, 2023 47.03 Mn
Dec 31, 2022 11.67 Mn
Sep 30, 2022 55.72 Mn
Jun 30, 2022 56.37 Mn
Mar 31, 2022 58.37 Mn
Dec 31, 2021 21.98 Mn
Sep 30, 2021 64.70 Mn
Jun 30, 2021 53.21 Mn