Karyopharm Therapeutics (KPTI) Accumulated Expenses (2012 - 2026)
Karyopharm Therapeutics' (KPTI) quarterly Accumulated Expenses came in at $4.4 million in Q4 2025, down 68.53% YoY from $13.9 million in Q4 2024, and down 93.4% on a QoQ basis from $66.3 million in Q3 2025.
Karyopharm Therapeutics (KPTI) Accumulated Expenses (2012 - 2026) Analysis & Trends
Karyopharm Therapeutics (KPTI) has 14 years of Accumulated Expenses data on file, last reported at $4.4 million in Q4 2025.
- Quarterly Accumulated Expenses fell 68.53% year-over-year to $4.4 million in Q4 2025, while the trailing twelve-month figure through Dec 2025 was $4.4 million (down 68.53% YoY) and the FY2025 annual result came in at $4.4 million, down 68.53% from the prior year.
- Accumulated Expenses retreated to $4.4 million in Q4 2025, from $66.3 million in the prior quarter.
- In the past five years, Accumulated Expenses ranged from a high of $66.3 million in Q3 2025 to a low of $4.4 million in Q4 2025.
- A 5-year average of $45.3 million and a median of $54.0 million in 2021 frame the typical range for Accumulated Expenses.
- Annual changes were most pronounced in 2021 — Accumulated Expenses surged 38.86% — and 2025, when it sank 68.53%.
- Tracing KPTI's Accumulated Expenses over 5 years: stood at $22.0 million in 2021, then tumbled by 46.89% to $11.7 million in 2022, then increased by 15.26% to $13.5 million in 2023, then advanced by 3.43% to $13.9 million in 2024, then tumbled by 68.53% to $4.4 million in 2025.
- The last three Accumulated Expenses figures came in at $4.4 million (Q4 2025), $66.3 million (Q3 2025), and $62.9 million (Q2 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) |
|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 139.13 Bn | 131.28 Bn | 2.84 Bn |
| 2 | Regeneron Pharmaceuticals | 85.77 Bn | 77.77 Bn | 3.93 Bn |
| 3 | Argenx Se | 64.64 Bn | 59.46 Bn | 1.37 Bn |
| 4 | Moderna | 58.29 Bn | 53.16 Bn | 52.00 Mn |
| 5 | BeOne Medicines | 41.92 Bn | 36.82 Bn | 1.53 Bn |
| 6 | Alnylam Pharmaceuticals | 31.58 Bn | 28.28 Bn | 992.69 Mn |
| 7 | BioNTech SE | 28.12 Bn | 9.73 Bn | 668.28 Mn |
| 8 | Insmed | 27.39 Bn | 26.22 Bn | 358.27 Mn |
| 9 | Royalty Pharma | 27.27 Bn | 26.43 Bn | - |
| 10 | Karyopharm Therapeutics | 56.72 Mn | 56.72 Mn | 32.35 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Jun 30, 2026 | 78.80 Mn |
| Dec 31, 2025 | 4.38 Mn |
| Sep 30, 2025 | 66.33 Mn |
| Jun 30, 2025 | 62.93 Mn |
| Mar 31, 2025 | 57.17 Mn |
| Dec 31, 2024 | 13.92 Mn |
| Sep 30, 2024 | 50.11 Mn |
| Jun 30, 2024 | 49.81 Mn |
| Mar 31, 2024 | 54.85 Mn |
| Dec 31, 2023 | 13.45 Mn |
| Sep 30, 2023 | 55.71 Mn |
| Jun 30, 2023 | 51.81 Mn |
| Mar 31, 2023 | 47.03 Mn |
| Dec 31, 2022 | 11.67 Mn |
| Sep 30, 2022 | 55.72 Mn |
| Jun 30, 2022 | 56.37 Mn |
| Mar 31, 2022 | 58.37 Mn |
| Dec 31, 2021 | 21.98 Mn |
| Sep 30, 2021 | 64.70 Mn |
| Jun 30, 2021 | 53.21 Mn |