Karyopharm Therapeutics (KPTI) Accumulated Expenses (2012 - 2025)

Karyopharm Therapeutics (KPTI) reported Accumulated Expenses of $10.3 million for Q4 2025, down 25.66% on a YoY basis from $13.9 million in Q4 2024, and down 84.4% quarter-over-quarter from $66.3 million in Q3 2025.

Karyopharm Therapeutics (KPTI) Accumulated Expenses (2012 - 2025) Analysis & Trends

Karyopharm Therapeutics has reported Accumulated Expenses for 14 years, with the latest figure at $10.3 million in Q4 2025.

  • For the quarter ending Q4 2025, Accumulated Expenses fell 25.66% year-over-year to $10.3 million; the trailing twelve-month figure through Dec 2025 stood at $10.3 million (down 25.66% YoY), and the FY2025 full-year result was $10.3 million, down 25.66% from the prior year.
  • Accumulated Expenses for Q4 2025 stood at $10.3 million, down from $66.3 million in the prior quarter.
  • The five-year high for Accumulated Expenses was $66.3 million in Q3 2025, with the low at $10.3 million in Q4 2025.
  • Historically, Accumulated Expenses has averaged $46.0 million across 5 years, with a median of $54.0 million in 2021.
  • Annual changes were most pronounced in 2021 — Accumulated Expenses surged 60.71% — and 2025, when it dropped 25.66%.
  • Karyopharm Therapeutics' Accumulated Expenses stood at $19.7 million in 2021, then fell by 0.31% to $19.6 million in 2022, then decreased by 15.87% to $16.5 million in 2023, then decreased by 15.72% to $13.9 million in 2024, then retreated by 25.66% to $10.3 million in 2025.
  • The last three Accumulated Expenses figures came in at $10.3 million (Q4 2025), $66.3 million (Q3 2025), and $62.9 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr)
1 Alterity Therapeutics 762,369.55 Bn 762,369.51 Bn -
2 Belite Bio 55,096.00 Bn 55,096.00 Bn -
3 Quantum Biopharma 17,755.80 Bn 17,755.79 Bn -
4 Legend Biotech 3,486.00 Bn 3,485.71 Bn 242.10 Mn
5 Akari Therapeutics 1,737.42 Bn 1,737.41 Bn -
6 Evaxion A 1,551.28 Bn 1,551.26 Bn -
7 Psyence Biomedical 227.32 Bn 227.31 Bn -
8 Vertex Pharmaceuticals 110.84 Bn 103.59 Bn 2.59 Bn
9 Abivax 91.71 Bn 91.71 Bn -
10 Karyopharm Therapeutics 95.31 Mn 31.56 Mn 32.74 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 10.34 Mn
Sep 30, 2025 66.33 Mn
Jun 30, 2025 62.93 Mn
Mar 31, 2025 57.17 Mn
Dec 31, 2024 13.92 Mn
Sep 30, 2024 50.11 Mn
Jun 30, 2024 49.81 Mn
Mar 31, 2024 54.85 Mn
Dec 31, 2023 16.51 Mn
Sep 30, 2023 55.71 Mn
Jun 30, 2023 51.81 Mn
Mar 31, 2023 47.03 Mn
Dec 31, 2022 19.63 Mn
Sep 30, 2022 55.72 Mn
Jun 30, 2022 56.37 Mn
Mar 31, 2022 58.37 Mn
Dec 31, 2021 19.69 Mn
Sep 30, 2021 64.70 Mn
Jun 30, 2021 53.21 Mn
Mar 31, 2021 55.61 Mn