Karyopharm Therapeutics (KPTI) Accumulated Expenses (2012 - 2025)
Karyopharm Therapeutics (KPTI) reported Accumulated Expenses of $10.3 million for Q4 2025, down 25.66% on a YoY basis from $13.9 million in Q4 2024, and down 84.4% quarter-over-quarter from $66.3 million in Q3 2025.
Karyopharm Therapeutics (KPTI) Accumulated Expenses (2012 - 2025) Analysis & Trends
Karyopharm Therapeutics has reported Accumulated Expenses for 14 years, with the latest figure at $10.3 million in Q4 2025.
- For the quarter ending Q4 2025, Accumulated Expenses fell 25.66% year-over-year to $10.3 million; the trailing twelve-month figure through Dec 2025 stood at $10.3 million (down 25.66% YoY), and the FY2025 full-year result was $10.3 million, down 25.66% from the prior year.
- Accumulated Expenses for Q4 2025 stood at $10.3 million, down from $66.3 million in the prior quarter.
- The five-year high for Accumulated Expenses was $66.3 million in Q3 2025, with the low at $10.3 million in Q4 2025.
- Historically, Accumulated Expenses has averaged $46.0 million across 5 years, with a median of $54.0 million in 2021.
- Annual changes were most pronounced in 2021 — Accumulated Expenses surged 60.71% — and 2025, when it dropped 25.66%.
- Karyopharm Therapeutics' Accumulated Expenses stood at $19.7 million in 2021, then fell by 0.31% to $19.6 million in 2022, then decreased by 15.87% to $16.5 million in 2023, then decreased by 15.72% to $13.9 million in 2024, then retreated by 25.66% to $10.3 million in 2025.
- The last three Accumulated Expenses figures came in at $10.3 million (Q4 2025), $66.3 million (Q3 2025), and $62.9 million (Q2 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) |
|---|---|---|---|---|
| 1 | Alterity Therapeutics | 762,369.55 Bn | 762,369.51 Bn | - |
| 2 | Belite Bio | 55,096.00 Bn | 55,096.00 Bn | - |
| 3 | Quantum Biopharma | 17,755.80 Bn | 17,755.79 Bn | - |
| 4 | Legend Biotech | 3,486.00 Bn | 3,485.71 Bn | 242.10 Mn |
| 5 | Akari Therapeutics | 1,737.42 Bn | 1,737.41 Bn | - |
| 6 | Evaxion A | 1,551.28 Bn | 1,551.26 Bn | - |
| 7 | Psyence Biomedical | 227.32 Bn | 227.31 Bn | - |
| 8 | Vertex Pharmaceuticals | 110.84 Bn | 103.59 Bn | 2.59 Bn |
| 9 | Abivax | 91.71 Bn | 91.71 Bn | - |
| 10 | Karyopharm Therapeutics | 95.31 Mn | 31.56 Mn | 32.74 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 10.34 Mn |
| Sep 30, 2025 | 66.33 Mn |
| Jun 30, 2025 | 62.93 Mn |
| Mar 31, 2025 | 57.17 Mn |
| Dec 31, 2024 | 13.92 Mn |
| Sep 30, 2024 | 50.11 Mn |
| Jun 30, 2024 | 49.81 Mn |
| Mar 31, 2024 | 54.85 Mn |
| Dec 31, 2023 | 16.51 Mn |
| Sep 30, 2023 | 55.71 Mn |
| Jun 30, 2023 | 51.81 Mn |
| Mar 31, 2023 | 47.03 Mn |
| Dec 31, 2022 | 19.63 Mn |
| Sep 30, 2022 | 55.72 Mn |
| Jun 30, 2022 | 56.37 Mn |
| Mar 31, 2022 | 58.37 Mn |
| Dec 31, 2021 | 19.69 Mn |
| Sep 30, 2021 | 64.70 Mn |
| Jun 30, 2021 | 53.21 Mn |
| Mar 31, 2021 | 55.61 Mn |