International Stem Cell (ISCO) FCF Margin (2010 - 2025)
International Stem Cell's (ISCO) quarterly FCF Margin came in at 1.35% in Q4 2025, up 441.0% year-over-year from 0.25% in Q4 2024, and down 30.7% quarter-over-quarter from 1.94% in Q3 2025.
Analysis
International Stem Cell (ISCO) FCF Margin (2010 - 2025) Analysis & Trends
International Stem Cell (ISCO) has reported FCF Margin for 16 consecutive years, with 1.35% the latest figure, recorded in Q4 2025.
- On a quarterly basis, FCF Margin rose 441.0% year-over-year to 1.35% in Q4 2025; TTM through Dec 2025 was 0.38%, a 130.0% increase from a year earlier, with the FY2025 full-year figure at 0.38%, up 130.0% from the prior year.
- FCF Margin was 1.35% for Q4 2025 at International Stem Cell, down from 1.94% in the prior quarter.
- Over five years, FCF Margin peaked at 23.85% in Q2 2023 and troughed at 23.76% in Q1 2021.
- A 5-year average of 0.94% and a median of 1.64% in 2025 frame the typical range for FCF Margin.
- Across the five-year window, FCF Margin plunged 3487 bps in 2021 and jumped 2928 bps in 2022, its largest moves.
- Over 5 years, FCF Margin stood at 17.69% in 2021, then surged by 118 bps to 3.25% in 2022, then jumped by 162 bps to 8.52% in 2023, then plunged by 136 bps to 3.07% in 2024, then jumped by 144 bps to 1.35% in 2025.
- The last three FCF Margin figures came in at 1.35% (Q4 2025), 1.94% (Q3 2025), and 13.57% (Q2 2025), per Business Quant data.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | FCF Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Krystal Biotech | 10.27 Bn | 9.43 Bn | 112.79 Mn | 59.74% |
| 2 | CRISPR Therapeutics AG | 5.17 Bn | 5.17 Bn | - | -826.50% |
| 3 | Iovance Biotherapeutics | 3.79 Bn | 3.49 Bn | 55.72 Mn | -66.71% |
| 4 | Legend Biotech | 3.68 Bn | 2.71 Bn | 251.50 Mn | -3.46% |
| 5 | uniQure | 3.05 Bn | 3.05 Bn | 5.49 Mn | -497.31% |
| 6 | Beam Therapeutics | 2.65 Bn | 2.65 Bn | - | -13,981.63% |
| 7 | Precigen | 2.44 Bn | 2.44 Bn | 52.17 Mn | -33.11% |
| 8 | Sarepta Therapeutics | 2.33 Bn | 1.53 Bn | 251.87 Mn | 48.98% |
| 9 | Vericel | 1.99 Bn | 1.83 Bn | 56.40 Mn | 18.67% |
| 10 | International Stem Cell | 2.84 Mn | 1.75 Mn | 1.46 Mn | - |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Dec 31, 2025 | 1.35% |
| Sep 30, 2025 | 1.94% |
| Jun 30, 2025 | -13.57% |
| Mar 31, 2025 | 10.43% |
| Dec 31, 2024 | -3.07% |
| Sep 30, 2024 | 10.10% |
| Jun 30, 2024 | -4.16% |
| Mar 31, 2024 | -9.44% |
| Dec 31, 2023 | 8.52% |
| Sep 30, 2023 | 2.43% |
| Jun 30, 2023 | 23.85% |
| Mar 31, 2023 | 9.64% |
| Dec 31, 2022 | 3.25% |
| Sep 30, 2022 | 4.93% |
| Jun 30, 2022 | 9.47% |
| Mar 31, 2022 | -1.14% |
| Dec 31, 2021 | -17.69% |
| Sep 30, 2021 | -12.16% |
| Jun 30, 2021 | -19.80% |
| Mar 31, 2021 | -23.76% |