International Stem Cell ISCO
OTC ISCO
$0.33 +0.00 (+0.00%)
At close: Sep 8, 2026 · 4:00 PM EDT

International Stem Cell (ISCO) FCF Margin (2010 - 2025)

International Stem Cell's (ISCO) quarterly FCF Margin came in at 1.35% in Q4 2025, up 441.0% year-over-year from 0.25% in Q4 2024, and down 30.7% quarter-over-quarter from 1.94% in Q3 2025.

Analysis

International Stem Cell (ISCO) FCF Margin (2010 - 2025) Analysis & Trends

International Stem Cell (ISCO) has reported FCF Margin for 16 consecutive years, with 1.35% the latest figure, recorded in Q4 2025.

  • On a quarterly basis, FCF Margin rose 441.0% year-over-year to 1.35% in Q4 2025; TTM through Dec 2025 was 0.38%, a 130.0% increase from a year earlier, with the FY2025 full-year figure at 0.38%, up 130.0% from the prior year.
  • FCF Margin was 1.35% for Q4 2025 at International Stem Cell, down from 1.94% in the prior quarter.
  • Over five years, FCF Margin peaked at 23.85% in Q2 2023 and troughed at 23.76% in Q1 2021.
  • A 5-year average of 0.94% and a median of 1.64% in 2025 frame the typical range for FCF Margin.
  • Across the five-year window, FCF Margin plunged 3487 bps in 2021 and jumped 2928 bps in 2022, its largest moves.
  • Over 5 years, FCF Margin stood at 17.69% in 2021, then surged by 118 bps to 3.25% in 2022, then jumped by 162 bps to 8.52% in 2023, then plunged by 136 bps to 3.07% in 2024, then jumped by 144 bps to 1.35% in 2025.
  • The last three FCF Margin figures came in at 1.35% (Q4 2025), 1.94% (Q3 2025), and 13.57% (Q2 2025), per Business Quant data.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) FCF Margin (Qtr)
1 Krystal Biotech 10.27 Bn 9.43 Bn 112.79 Mn 59.74%
2 CRISPR Therapeutics AG 5.17 Bn 5.17 Bn - -826.50%
3 Iovance Biotherapeutics 3.79 Bn 3.49 Bn 55.72 Mn -66.71%
4 Legend Biotech 3.68 Bn 2.71 Bn 251.50 Mn -3.46%
5 uniQure 3.05 Bn 3.05 Bn 5.49 Mn -497.31%
6 Beam Therapeutics 2.65 Bn 2.65 Bn - -13,981.63%
7 Precigen 2.44 Bn 2.44 Bn 52.17 Mn -33.11%
8 Sarepta Therapeutics 2.33 Bn 1.53 Bn 251.87 Mn 48.98%
9 Vericel 1.99 Bn 1.83 Bn 56.40 Mn 18.67%
10 International Stem Cell 2.84 Mn 1.75 Mn 1.46 Mn -
Historic Data

Historic Data

Download Data
DateValue
Dec 31, 2025 1.35%
Sep 30, 2025 1.94%
Jun 30, 2025 -13.57%
Mar 31, 2025 10.43%
Dec 31, 2024 -3.07%
Sep 30, 2024 10.10%
Jun 30, 2024 -4.16%
Mar 31, 2024 -9.44%
Dec 31, 2023 8.52%
Sep 30, 2023 2.43%
Jun 30, 2023 23.85%
Mar 31, 2023 9.64%
Dec 31, 2022 3.25%
Sep 30, 2022 4.93%
Jun 30, 2022 9.47%
Mar 31, 2022 -1.14%
Dec 31, 2021 -17.69%
Sep 30, 2021 -12.16%
Jun 30, 2021 -19.80%
Mar 31, 2021 -23.76%