International Stem Cell (ISCO) EV to CFO (2010 - 2025)
International Stem Cell's (ISCO) quarterly EV to CFO came in at 3.99 in Q4 2025, down 49.95% year-over-year from 7.97 in Q4 2024, and up 162.05% quarter-over-quarter from 1.52 in Q3 2025.
Powered by 
Analysis
International Stem Cell (ISCO) EV to CFO (2010 - 2025) Analysis & Trends
International Stem Cell (ISCO) has reported EV to CFO for 16 consecutive years, with 3.99 the latest figure, recorded in Q4 2025.
- On a quarterly basis, EV to CFO fell 49.95% year-over-year to 3.99 in Q4 2025; TTM through Dec 2025 was 15.95, a 135.17% increase from a year earlier, with the FY2025 full-year figure at 15.95, up 135.17% from the prior year.
- EV to CFO was 3.99 for Q4 2025 at International Stem Cell, up from 1.52 in the prior quarter.
- Over five years, EV to CFO peaked at 27.33 in Q3 2022 and troughed at 149.74 in Q1 2022.
- A 5-year average of 9.48 and a median of 1.68 in 2025 frame the typical range for EV to CFO.
- Across the five-year window, EV to CFO soared 263.8% in 2022 and sank 4952.56% in 2024, its largest moves.
- Over 5 years, EV to CFO stood at 11.36 in 2021, then surged by 177.84% to 8.85 in 2022, then sank by 177.78% to 6.88 in 2023, then soared by 215.81% to 7.97 in 2024, then tumbled by 49.95% to 3.99 in 2025.
- The last three EV to CFO figures came in at 3.99 (Q4 2025), 1.52 (Q3 2025), and 1.2 (Q2 2025), per Business Quant data.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) |
|---|---|---|---|---|
| 1 | Krystal Biotech | 10.27 Bn | 9.43 Bn | 112.79 Mn |
| 2 | CRISPR Therapeutics AG | 5.17 Bn | 5.17 Bn | - |
| 3 | Iovance Biotherapeutics | 3.79 Bn | 3.49 Bn | 55.72 Mn |
| 4 | Legend Biotech | 3.68 Bn | 2.71 Bn | 251.50 Mn |
| 5 | uniQure | 3.05 Bn | 3.05 Bn | 5.49 Mn |
| 6 | Beam Therapeutics | 2.65 Bn | 2.65 Bn | - |
| 7 | Precigen | 2.44 Bn | 2.44 Bn | 52.17 Mn |
| 8 | Sarepta Therapeutics | 2.33 Bn | 1.53 Bn | 251.87 Mn |
| 9 | Vericel | 1.99 Bn | 1.83 Bn | 56.40 Mn |
| 10 | International Stem Cell | 2.84 Mn | 1.75 Mn | 1.46 Mn |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Dec 31, 2025 | 3.99 |
| Sep 30, 2025 | 1.52 |
| Jun 30, 2025 | -1.20 |
| Mar 31, 2025 | -2.17 |
| Dec 31, 2024 | 7.97 |
| Sep 30, 2024 | -3.22 |
| Jun 30, 2024 | -35.21 |
| Mar 31, 2024 | 3.03 |
| Dec 31, 2023 | -6.88 |
| Sep 30, 2023 | -7.57 |
| Jun 30, 2023 | -0.70 |
| Mar 31, 2023 | 2.30 |
| Dec 31, 2022 | 8.85 |
| Sep 30, 2022 | 27.33 |
| Jun 30, 2022 | 14.04 |
| Mar 31, 2022 | -149.74 |
| Dec 31, 2021 | -11.36 |
| Sep 30, 2021 | -16.68 |
| Jun 30, 2021 | -12.71 |
| Mar 31, 2021 | -11.13 |