Ionis Pharmaceuticals (IONS) Research & Development (2009 - 2026)

Ionis Pharmaceuticals' (IONS) quarterly Research & Development came in at $210.2 million in Q1 2026, up 4.69% year-on-year from $200.8 million in Q1 2025, and down 24.84% quarter-over-quarter from $279.6 million in Q4 2025.

Ionis Pharmaceuticals (IONS) Research & Development (2009 - 2026) Analysis & Trends

Ionis Pharmaceuticals' Research & Development history runs 18 years deep, the most recent figure standing at $210.2 million for Q1 2026.

  • On a quarterly basis, Research & Development rose 4.69% year-over-year to $210.2 million in Q1 2026; TTM through Mar 2026 was $925.0 million, a 4.16% increase from a year earlier, with the FY2025 full-year figure at $915.6 million, up 1.56% from the prior year.
  • Research & Development fell to $210.2 million in Q1 2026 per IONS's latest filing, from $279.6 million in the prior quarter.
  • Across five years, Research & Development topped out at $279.6 million in Q4 2025 and bottomed at -$444.9 million in Q4 2022.
  • The 5-year median for Research & Development is $215.3 million (2023), against an average of $176.9 million.
  • Across the five-year window, Research & Development soared 157.67% in 2023 and slipped 6.28% in 2025, its largest moves.
  • Year by year, Research & Development stood at -$444.9 million in 2022, then surged by 157.67% to $256.6 million in 2023, then dropped by 4.31% to $245.5 million in 2024, then rose by 13.91% to $279.6 million in 2025, then fell by 24.84% to $210.2 million in 2026.
  • Per Business Quant, the three latest IONS Research & Development figures stand at $210.2 million (Q1 2026), $279.6 million (Q4 2025), and $217.8 million (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) R&D (Qtr)
1 Oculis Holding AG 67,072.09 Bn 67,072.09 Bn - -17.94 Mn
2 Nanobiotix 1,894.61 Bn 1,894.55 Bn - -
3 Akari Therapeutics 1,014.18 Bn 1,014.18 Bn - 1.46 Mn
4 BeOne Medicines 471.64 Bn 466.85 Bn 1.35 Bn 541.22 Mn
5 Vertex Pharmaceuticals 121.72 Bn 114.47 Bn 2.59 Bn 961.60 Mn
6 Regeneron Pharmaceuticals 68.28 Bn 59.52 Bn 3.31 Bn 1.54 Bn
7 Belite Bio 61.40 Bn 61.40 Bn - 15.66 Mn
8 Argenx Se 56.94 Bn 56.94 Bn 1.18 Bn -443.00 Mn
9 Revolution Medicines 37.37 Bn 37.37 Bn - 343.97 Mn
10 Ionis Pharmaceuticals 9.35 Bn 7.43 Bn 243.11 Mn 210.17 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 210.17 Mn
Dec 31, 2025 279.65 Mn
Sep 30, 2025 217.75 Mn
Jun 30, 2025 217.46 Mn
Mar 31, 2025 200.76 Mn
Dec 31, 2024 245.49 Mn
Sep 30, 2024 219.76 Mn
Jun 30, 2024 222.06 Mn
Mar 31, 2024 214.22 Mn
Dec 31, 2023 256.56 Mn
Sep 30, 2023 215.33 Mn
Jun 30, 2023 229.93 Mn
Mar 31, 2023 197.81 Mn
Dec 31, 2022 -444.88 Mn
Sep 30, 2022 182.99 Mn
Jun 30, 2022 180.76 Mn
Mar 31, 2022 161.13 Mn
Dec 31, 2021 -429.08 Mn
Sep 30, 2021 184.77 Mn
Jun 30, 2021 139.31 Mn