Ionis Pharmaceuticals (IONS) Net Margin (2009 - 2026)
Ionis Pharmaceuticals (IONS) recorded Net Margin of -42.79% in Q2 2026, down 70.12 percentage points from 27.33% a year earlier and down 5.19 percentage points from the prior quarter.
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Analysis
Ionis Pharmaceuticals (IONS) Net Margin (2009 - 2026) Analysis & Trends
On a TTM basis, Ionis Pharmaceuticals' Net Margin came in at -64.66% as of Jun 30, 2026, down 36.25 percentage points year-over-year; for FY2025, it was 13.52%, up 77.89 percentage points from FY2024.
- Annual Net Margin has a five-year change of +74.44 percentage points (FY2020 to FY2025).
- Across earlier years, Net Margin came in at -64.37% in FY2024 (-17.87 pp), -46.50% in FY2023 (-0.58 pp), -45.92% in FY2022 (-42.39 pp) and -3.53% in FY2021 (+57.39 pp).
- Quarterly Net Margin has ranged from -119.50% in Q1 2024 to 51.05% in Q4 2021 over the past five years.
- On a year-over-year basis, Net Margin rose in four of the last eight quarters, with an average year-over-year change of -2.66 percentage points.
- Peak year-over-year performance for Net Margin in the last five years was a gain of 173.18 percentage points in Q4 2021, against a drop of 85.57 percentage points in Q4 2022 at the low end.
- Per Business Quant, the preceding three quarters came in at -37.60% (Q1 2026), -112.82% (Q4 2025) and -82.06% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 21.86% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 21.27% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -8.04% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 22.61% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 18.81% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 23.62% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -134.51% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | -1.65% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 32.99% |
| 10 | Ionis Pharmaceuticals | 7.55 Bn | -1.34 Bn | 265.21 Mn | -42.79% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -42.79% |
| Mar 31, 2026 | -37.60% |
| Dec 31, 2025 | -112.82% |
| Sep 30, 2025 | -82.06% |
| Jun 30, 2025 | 27.33% |
| Mar 31, 2025 | -111.64% |
| Dec 31, 2024 | -46.05% |
| Sep 30, 2024 | -104.98% |
| Jun 30, 2024 | -29.42% |
| Mar 31, 2024 | -119.50% |
| Dec 31, 2023 | -2.85% |
| Sep 30, 2023 | -102.22% |
| Jun 30, 2023 | -45.27% |
| Mar 31, 2023 | -95.25% |
| Dec 31, 2022 | -34.52% |
| Sep 30, 2022 | -29.41% |
| Jun 30, 2022 | -78.58% |
| Mar 31, 2022 | -45.92% |
| Dec 31, 2021 | 51.05% |
| Sep 30, 2021 | -61.96% |
API Access
Ionis Pharmaceuticals Net Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=net-margin&ticker=IONS&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "net-margin", "ticker": "IONS", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=net-margin&ticker=IONS&period=max&api_key=YOUR_API_KEY");
const data = await res.json();