Ionis Pharmaceuticals (IONS) Net Cash Flow (2009 - 2026)

Ionis Pharmaceuticals (IONS) recorded quarterly Net Cash Flow of -$198.7 million in Q1 2026, down 685.19% quarter-over-quarter from $34.0 million in Q4 2025, and down 1008.2% on a YoY basis from $21.9 million in Q1 2025.

Ionis Pharmaceuticals (IONS) Net Cash Flow (2009 - 2026) Analysis & Trends

Ionis Pharmaceuticals' Net Cash Flow history runs 18 years deep, the most recent figure standing at -$198.7 million for Q1 2026.

  • In Q1 2026, Net Cash Flow fell 1008.2% year-over-year to -$198.7 million; the TTM figure through Mar 2026 stood at -$91.1 million (down 7.52% YoY), while the FY2025 annual figure was $129.5 million, up 182.52% from the prior year.
  • Net Cash Flow was -$198.7 million for Q1 2026 at Ionis Pharmaceuticals, down from $34.0 million in the prior quarter.
  • In the past five years, Net Cash Flow ranged from a high of $115.7 million in Q2 2023 to a low of -$326.5 million in Q1 2022.
  • Historically, Net Cash Flow has averaged -$40.9 million across 5 years, with a median of -$20.2 million in 2022.
  • The sharpest annual moves came in 2022 and 2023: Net Cash Flow sank 2065.0% in 2022, then surged 673.14% in 2023.
  • A 5-year view of Net Cash Flow shows it stood at -$39.1 million in 2022, then jumped by 219.99% to $46.9 million in 2023, then sank by 296.35% to -$92.0 million in 2024, then surged by 136.9% to $34.0 million in 2025, then plunged by 685.19% to -$198.7 million in 2026.
  • The last three Net Cash Flow figures came in at -$198.7 million (Q1 2026), $34.0 million (Q4 2025), and $41.1 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Net Cash Flow (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - 2.44 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn 625.70 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -2.44 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 457.40 Mn
9 Abivax 91.96 Bn 91.96 Bn - 664,983.53
10 Ionis Pharmaceuticals 12.23 Bn 10.31 Bn 243.11 Mn -198.74 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -198.74 Mn
Mar 31, 2026 -198.74 Mn
Dec 31, 2025 33.96 Mn
Dec 31, 2025 33.96 Mn
Sep 30, 2025 41.12 Mn
Sep 30, 2025 41.12 Mn
Jun 30, 2025 32.52 Mn
Jun 30, 2025 32.52 Mn
Mar 31, 2025 21.88 Mn
Mar 31, 2025 21.88 Mn
Dec 31, 2024 -92.04 Mn
Dec 31, 2024 -92.04 Mn
Sep 30, 2024 40.26 Mn
Sep 30, 2024 40.26 Mn
Jun 30, 2024 -54.87 Mn
Jun 30, 2024 -54.87 Mn
Mar 31, 2024 -50.26 Mn
Mar 31, 2024 -50.26 Mn
Dec 31, 2023 46.88 Mn
Dec 31, 2023 46.88 Mn