Ionis Pharmaceuticals (IONS) Free Cash Flow (2009 - 2026)
Ionis Pharmaceuticals (IONS) posted quarterly Free Cash Flow of $549.5 million for Q2 2026, up 295.19% year-over-year from $139.0 million in Q2 2025, and up 167.45% quarter-over-quarter from -$814.6 million in Q1 2026.
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Ionis Pharmaceuticals (IONS) Free Cash Flow (2009 - 2026) Analysis & Trends
Ionis Pharmaceuticals' Free Cash Flow history runs 18 years deep, the most recent figure standing at $549.5 million for Q2 2026.
- In Q2 2026, Free Cash Flow rose 295.19% year-over-year to $549.5 million; the TTM figure through Jun 2026 stood at -$560.8 million (down 93.39% YoY), while the FY2025 annual figure was -$320.0 million, up 41.41% from the prior year.
- Free Cash Flow for Q2 2026 stood at $549.5 million, up from -$814.6 million in the prior quarter.
- The five-year high for Free Cash Flow was $549.5 million in Q2 2026, with the low at -$814.6 million in Q1 2026.
- The 5-year median for Free Cash Flow is -$125.1 million (2024), against an average of -$97.4 million.
- The sharpest annual moves came in 2024 and 2026: Free Cash Flow tumbled 520.48% in 2024, then soared 295.19% in 2026.
- Ionis Pharmaceuticals' Free Cash Flow stood at -$204.3 million in 2022, then surged by 116.48% to $33.7 million in 2023, then sank by 520.48% to -$141.6 million in 2024, then dropped by 12.26% to -$159.0 million in 2025, then surged by 445.56% to $549.5 million in 2026.
- Business Quant data shows IONS's Free Cash Flow at $549.5 million in Q2 2026, -$814.6 million in Q1 2026, and -$159.0 million in Q4 2025.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Free Cash Flow (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 138.78 Bn | 130.92 Bn | 2.84 Bn | 1.01 Bn |
| 2 | Regeneron Pharmaceuticals | 85.50 Bn | 77.51 Bn | 3.93 Bn | 572.80 Mn |
| 3 | Argenx Se | 63.51 Bn | 58.32 Bn | 1.37 Bn | - |
| 4 | Moderna | 58.06 Bn | 52.92 Bn | 52.00 Mn | -563.00 Mn |
| 5 | Revolution Medicines | 44.04 Bn | 44.04 Bn | - | -389.61 Mn |
| 6 | BeOne Medicines | 40.04 Bn | 34.94 Bn | 1.53 Bn | 437.80 Mn |
| 7 | Alnylam Pharmaceuticals | 35.45 Bn | 32.14 Bn | 992.69 Mn | 292.04 Mn |
| 8 | Royalty Pharma | 28.41 Bn | 27.57 Bn | - | 477.44 Mn |
| 9 | Insmed | 27.42 Bn | 26.26 Bn | 358.27 Mn | -95.09 Mn |
| 10 | Ionis Pharmaceuticals | 9.67 Bn | 7.62 Bn | 265.21 Mn | 549.45 Mn |
Historic Data
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Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | 549.45 Mn |
| Mar 31, 2026 | -814.58 Mn |
| Dec 31, 2025 | -159.00 Mn |
| Sep 30, 2025 | -136.71 Mn |
| Jun 30, 2025 | 139.03 Mn |
| Mar 31, 2025 | -163.35 Mn |
| Dec 31, 2024 | -141.64 Mn |
| Sep 30, 2024 | -124.05 Mn |
| Jun 30, 2024 | -126.11 Mn |
| Mar 31, 2024 | -154.43 Mn |
| Dec 31, 2023 | 33.68 Mn |
| Sep 30, 2023 | -111.16 Mn |
| Jun 30, 2023 | -109.38 Mn |
| Mar 31, 2023 | -144.46 Mn |
| Dec 31, 2022 | -204.33 Mn |
| Sep 30, 2022 | -29.97 Mn |
| Jun 30, 2022 | -21.43 Mn |
| Mar 31, 2022 | -34.36 Mn |
| Dec 31, 2021 | 201.19 Mn |
| Sep 30, 2021 | -58.90 Mn |