Ionis Pharmaceuticals (IONS) Free Cash Flow (2009 - 2026)

Ionis Pharmaceuticals' (IONS) quarterly Free Cash Flow came in at -$814.6 million in Q1 2026, down 398.67% year-on-year from $272.7 million in Q1 2025, and down 654.0% quarter-over-quarter from -$108.0 million in Q4 2025.

Ionis Pharmaceuticals (IONS) Free Cash Flow (2009 - 2026) Analysis & Trends

Ionis Pharmaceuticals' Free Cash Flow history runs 18 years deep, the most recent figure standing at -$814.6 million for Q1 2026.

  • On a quarterly basis, Free Cash Flow fell 398.67% year-over-year to -$814.6 million in Q1 2026; TTM through Mar 2026 was -$920.3 million, a 65.77% decrease from a year earlier, with the FY2025 full-year figure at -$269.1 million, up 50.74% from the prior year.
  • Free Cash Flow fell to -$814.6 million in Q1 2026 per IONS's latest filing, from -$108.0 million in the prior quarter.
  • Across five years, Free Cash Flow topped out at $139.0 million in Q2 2025 and bottomed at -$814.6 million in Q1 2026.
  • The 5-year median for Free Cash Flow is -$124.0 million (2024), against an average of -$132.4 million.
  • Across the five-year window, Free Cash Flow plunged 520.48% in 2024 and surged 210.24% in 2025, its largest moves.
  • Year by year, Free Cash Flow stood at -$204.3 million in 2022, then soared by 116.48% to $33.7 million in 2023, then plunged by 520.48% to -$141.6 million in 2024, then rose by 23.72% to -$108.0 million in 2025, then sank by 654.0% to -$814.6 million in 2026.
  • Per Business Quant, the three latest IONS Free Cash Flow figures stand at -$814.6 million (Q1 2026), -$108.0 million (Q4 2025), and -$136.7 million (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Free Cash Flow (Qtr)
1 Oculis Holding AG 68,785.72 Bn 68,785.72 Bn - -19.58 Mn
2 Nanobiotix 1,895.57 Bn 1,895.51 Bn - -
3 BeOne Medicines 471.35 Bn 466.56 Bn 1.35 Bn 158.09 Mn
4 NuCana 279.75 Bn 279.75 Bn - -1.53 Mn
5 Vertex Pharmaceuticals 120.24 Bn 113.00 Bn 2.59 Bn 1.29 Bn
6 Regeneron Pharmaceuticals 67.80 Bn 59.04 Bn 3.31 Bn 848.30 Mn
7 Belite Bio 62.51 Bn 62.51 Bn - -
8 Argenx Se 57.38 Bn 57.38 Bn 1.41 Bn -
9 Revolution Medicines 37.78 Bn 37.78 Bn - -354.95 Mn
10 Ionis Pharmaceuticals 9.21 Bn 7.29 Bn 243.11 Mn -814.58 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -814.58 Mn
Mar 31, 2026 -814.58 Mn
Dec 31, 2025 -108.04 Mn
Dec 31, 2025 -108.04 Mn
Sep 30, 2025 -136.71 Mn
Sep 30, 2025 -136.71 Mn
Jun 30, 2025 139.03 Mn
Jun 30, 2025 139.03 Mn
Mar 31, 2025 -163.35 Mn
Mar 31, 2025 -163.35 Mn
Dec 31, 2024 -141.64 Mn
Dec 31, 2024 -141.64 Mn
Sep 30, 2024 -124.05 Mn
Sep 30, 2024 -124.05 Mn
Jun 30, 2024 -126.11 Mn
Jun 30, 2024 -126.11 Mn
Mar 31, 2024 -154.43 Mn
Mar 31, 2024 -154.43 Mn
Dec 31, 2023 33.68 Mn
Dec 31, 2023 33.68 Mn