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Ionis Pharmaceuticals (IONS) Free Cash Flow (2016 - 2025)

Ionis Pharmaceuticals has reported Free Cash Flow over the past 17 years, most recently at -$108.0 million for Q4 2025.

  • Quarterly results put Free Cash Flow at -$108.0 million for Q4 2025, up 23.72% from a year ago — trailing twelve months through Dec 2025 was -$269.1 million (up 50.74% YoY), and the annual figure for FY2025 was -$269.1 million, up 50.74%.
  • Free Cash Flow for Q4 2025 was -$108.0 million at Ionis Pharmaceuticals, up from -$136.7 million in the prior quarter.
  • Over the last five years, Free Cash Flow for IONS hit a ceiling of $201.2 million in Q4 2021 and a floor of -$204.3 million in Q4 2022.
  • Median Free Cash Flow over the past 5 years was -$108.7 million (2023), compared with a mean of -$70.9 million.
  • Biggest five-year swings in Free Cash Flow: crashed 564.24% in 2021 and later surged 210.24% in 2025.
  • Ionis Pharmaceuticals' Free Cash Flow stood at $201.2 million in 2021, then plummeted by 201.57% to -$204.3 million in 2022, then skyrocketed by 116.48% to $33.7 million in 2023, then plummeted by 520.48% to -$141.6 million in 2024, then grew by 23.72% to -$108.0 million in 2025.
  • The last three reported values for Free Cash Flow were -$108.0 million (Q4 2025), -$136.7 million (Q3 2025), and $139.0 million (Q2 2025) per Business Quant data.