Ionis Pharmaceuticals (IONS) EBITDA Margin (2013 - 2026)
Ionis Pharmaceuticals (IONS) recorded EBITDA Margin of -36.63% in Q2 2026, down 68.20 percentage points from 31.56% a year earlier but up 9.47 percentage points from the prior quarter.
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Ionis Pharmaceuticals (IONS) EBITDA Margin (2013 - 2026) Analysis & Trends
On a TTM basis, Ionis Pharmaceuticals' EBITDA Margin came in at -66.30% as of Jun 30, 2026, down 39.27 percentage points year-over-year; for FY2025, it came in at -39.13%, up 26.55 percentage points from FY2024.
- Annual EBITDA Margin has a five-year change of -17.65 percentage points (FY2020 to FY2025).
- Across earlier years, EBITDA Margin came in at -65.68% in FY2024 (-22.40 pp), -43.28% in FY2023 (+23.71 pp), -66.99% in FY2022 (-65.46 pp) and -1.52% in FY2021 (+19.96 pp).
- Quarterly EBITDA Margin has ranged from -134.56% in Q4 2022 to 51.14% in Q4 2021 over the past five years.
- On a year-over-year basis, EBITDA Margin rose in four of the last eight quarters, with an average year-over-year change of -4.78 percentage points.
- Peak year-over-year performance for EBITDA Margin in the last five years was a gain of 133.66 percentage points in Q4 2023, against a drop of 185.70 percentage points in Q4 2022 at the low end.
- Per Business Quant, the preceding three quarters came in at -46.11% (Q1 2026), -103.56% (Q4 2025) and -100.37% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 35.95% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 49.01% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | 6.02% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | - |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 33.11% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 46.01% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -124.26% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 39.16% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 39.10% |
| 10 | Ionis Pharmaceuticals | 7.55 Bn | -1.34 Bn | 265.21 Mn | -36.63% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -36.63% |
| Mar 31, 2026 | -46.11% |
| Dec 31, 2025 | -103.56% |
| Sep 30, 2025 | -100.37% |
| Jun 30, 2025 | 31.56% |
| Mar 31, 2025 | -109.45% |
| Dec 31, 2024 | -47.72% |
| Sep 30, 2024 | -108.87% |
| Jun 30, 2024 | -27.97% |
| Mar 31, 2024 | -122.45% |
| Dec 31, 2023 | -0.90% |
| Sep 30, 2023 | -97.14% |
| Jun 30, 2023 | -46.14% |
| Mar 31, 2023 | -84.99% |
| Dec 31, 2022 | -134.56% |
| Sep 30, 2022 | -34.26% |
| Jun 30, 2022 | -60.64% |
| Mar 31, 2022 | -37.49% |
| Dec 31, 2021 | 51.14% |
| Sep 30, 2021 | -61.26% |
API Access
Ionis Pharmaceuticals EBITDA Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=ebitda-margin&ticker=IONS&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "ebitda-margin", "ticker": "IONS", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=ebitda-margin&ticker=IONS&period=max&api_key=YOUR_API_KEY");
const data = await res.json();