Ionis Pharmaceuticals (IONS) Change in Cash (2009 - 2026)

Ionis Pharmaceuticals' (IONS) quarterly Change in Cash came in at -$198.9 million in Q1 2026, down 999.29% year-on-year from $22.1 million in Q1 2025, and down 686.34% quarter-over-quarter from $33.9 million in Q4 2025.

Ionis Pharmaceuticals (IONS) Change in Cash (2009 - 2026) Analysis & Trends

Ionis Pharmaceuticals' Change in Cash history runs 18 years deep, the most recent figure standing at -$198.9 million for Q1 2026.

  • On a quarterly basis, Change in Cash fell 999.29% year-over-year to -$198.9 million in Q1 2026; TTM through Mar 2026 was -$90.8 million, a 7.22% decrease from a year earlier, with the FY2025 full-year figure at $130.2 million, up 182.82% from the prior year.
  • Change in Cash declined to -$198.9 million in Q1 2026 per IONS's latest filing, from $33.9 million in the prior quarter.
  • Across five years, Change in Cash topped out at $115.8 million in Q2 2023 and bottomed at -$326.7 million in Q1 2022.
  • The 5-year median for Change in Cash is -$20.6 million (2022), against an average of -$40.9 million.
  • Across the five-year window, Change in Cash sank 2080.95% in 2022 and soared 662.05% in 2023, its largest moves.
  • Year by year, Change in Cash stood at -$38.5 million in 2022, then jumped by 222.55% to $47.2 million in 2023, then plunged by 296.01% to -$92.5 million in 2024, then surged by 136.66% to $33.9 million in 2025, then plunged by 686.34% to -$198.9 million in 2026.
  • Per Business Quant, the three latest IONS Change in Cash figures stand at -$198.9 million (Q1 2026), $33.9 million (Q4 2025), and $41.0 million (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Change in Cash (Qtr)
1 Oculis Holding AG 68,785.72 Bn 68,785.72 Bn - -22.03 Mn
2 Nanobiotix 1,895.57 Bn 1,895.51 Bn - -
3 BeOne Medicines 471.35 Bn 466.56 Bn 1.35 Bn 243.78 Mn
4 NuCana 279.75 Bn 279.75 Bn - -1.34 Mn
5 Vertex Pharmaceuticals 120.24 Bn 113.00 Bn 2.59 Bn 417.10 Mn
6 Regeneron Pharmaceuticals 67.80 Bn 59.04 Bn 3.31 Bn -153.10 Mn
7 Belite Bio 62.51 Bn 62.51 Bn - -
8 Argenx Se 57.38 Bn 57.38 Bn 1.41 Bn -
9 Revolution Medicines 37.78 Bn 37.78 Bn - 57.19 Mn
10 Ionis Pharmaceuticals 9.21 Bn 7.29 Bn 243.11 Mn -198.88 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -198.88 Mn
Dec 31, 2025 33.92 Mn
Sep 30, 2025 41.04 Mn
Jun 30, 2025 33.11 Mn
Mar 31, 2025 22.12 Mn
Dec 31, 2024 -92.53 Mn
Sep 30, 2024 40.61 Mn
Jun 30, 2024 -54.90 Mn
Mar 31, 2024 -50.38 Mn
Dec 31, 2023 47.21 Mn
Sep 30, 2023 -72.73 Mn
Jun 30, 2023 115.76 Mn
Mar 31, 2023 32.56 Mn
Dec 31, 2022 -38.52 Mn
Sep 30, 2022 -206.92 Mn
Jun 30, 2022 -20.60 Mn
Mar 31, 2022 -326.68 Mn
Dec 31, 2021 236.24 Mn
Sep 30, 2021 67.83 Mn
Jun 30, 2021 150.96 Mn