Ionis Pharmaceuticals (IONS) Change in Cash (2009 - 2026)
Ionis Pharmaceuticals (IONS) recorded quarterly Change in Cash of -$198.9 million in Q1 2026, down 686.34% quarter-over-quarter from $33.9 million in Q4 2025, and down 999.29% on a YoY basis from $22.1 million in Q1 2025.
Ionis Pharmaceuticals (IONS) Change in Cash (2009 - 2026) Analysis & Trends
Ionis Pharmaceuticals' Change in Cash history runs 18 years deep, the most recent figure standing at -$198.9 million for Q1 2026.
- In Q1 2026, Change in Cash fell 999.29% year-over-year to -$198.9 million; the TTM figure through Mar 2026 stood at -$90.8 million (down 7.22% YoY), while the FY2025 annual figure was $130.2 million, up 182.82% from the prior year.
- Change in Cash was -$198.9 million for Q1 2026 at Ionis Pharmaceuticals, down from $33.9 million in the prior quarter.
- In the past five years, Change in Cash ranged from a high of $115.8 million in Q2 2023 to a low of -$326.7 million in Q1 2022.
- Historically, Change in Cash has averaged -$40.9 million across 5 years, with a median of -$20.6 million in 2022.
- The sharpest annual moves came in 2022 and 2023: Change in Cash sank 2080.95% in 2022, then jumped 662.05% in 2023.
- A 5-year view of Change in Cash shows it stood at -$38.5 million in 2022, then jumped by 222.55% to $47.2 million in 2023, then slumped by 296.01% to -$92.5 million in 2024, then surged by 136.66% to $33.9 million in 2025, then slumped by 686.34% to -$198.9 million in 2026.
- The last three Change in Cash figures came in at -$198.9 million (Q1 2026), $33.9 million (Q4 2025), and $41.0 million (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Change in Cash (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | 2.44 Mn |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | 623.00 Mn |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | - |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | -2.44 Mn |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 417.10 Mn |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | -45.97 Mn |
| 10 | Ionis Pharmaceuticals | 12.23 Bn | 10.31 Bn | 243.11 Mn | -198.88 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -198.88 Mn |
| Dec 31, 2025 | 33.92 Mn |
| Sep 30, 2025 | 41.04 Mn |
| Jun 30, 2025 | 33.11 Mn |
| Mar 31, 2025 | 22.12 Mn |
| Dec 31, 2024 | -92.53 Mn |
| Sep 30, 2024 | 40.61 Mn |
| Jun 30, 2024 | -54.90 Mn |
| Mar 31, 2024 | -50.38 Mn |
| Dec 31, 2023 | 47.21 Mn |
| Sep 30, 2023 | -72.73 Mn |
| Jun 30, 2023 | 115.76 Mn |
| Mar 31, 2023 | 32.56 Mn |
| Dec 31, 2022 | -38.52 Mn |
| Sep 30, 2022 | -206.92 Mn |
| Jun 30, 2022 | -20.60 Mn |
| Mar 31, 2022 | -326.68 Mn |
| Dec 31, 2021 | 236.24 Mn |
| Sep 30, 2021 | 67.83 Mn |
| Jun 30, 2021 | 150.96 Mn |