Ionis Pharmaceuticals (IONS) Change in Cash (2009 - 2026)

Ionis Pharmaceuticals (IONS) recorded quarterly Change in Cash of -$198.9 million in Q1 2026, down 686.34% quarter-over-quarter from $33.9 million in Q4 2025, and down 999.29% on a YoY basis from $22.1 million in Q1 2025.

Ionis Pharmaceuticals (IONS) Change in Cash (2009 - 2026) Analysis & Trends

Ionis Pharmaceuticals' Change in Cash history runs 18 years deep, the most recent figure standing at -$198.9 million for Q1 2026.

  • In Q1 2026, Change in Cash fell 999.29% year-over-year to -$198.9 million; the TTM figure through Mar 2026 stood at -$90.8 million (down 7.22% YoY), while the FY2025 annual figure was $130.2 million, up 182.82% from the prior year.
  • Change in Cash was -$198.9 million for Q1 2026 at Ionis Pharmaceuticals, down from $33.9 million in the prior quarter.
  • In the past five years, Change in Cash ranged from a high of $115.8 million in Q2 2023 to a low of -$326.7 million in Q1 2022.
  • Historically, Change in Cash has averaged -$40.9 million across 5 years, with a median of -$20.6 million in 2022.
  • The sharpest annual moves came in 2022 and 2023: Change in Cash sank 2080.95% in 2022, then jumped 662.05% in 2023.
  • A 5-year view of Change in Cash shows it stood at -$38.5 million in 2022, then jumped by 222.55% to $47.2 million in 2023, then slumped by 296.01% to -$92.5 million in 2024, then surged by 136.66% to $33.9 million in 2025, then slumped by 686.34% to -$198.9 million in 2026.
  • The last three Change in Cash figures came in at -$198.9 million (Q1 2026), $33.9 million (Q4 2025), and $41.0 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Change in Cash (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - 2.44 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn 623.00 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -2.44 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 417.10 Mn
9 Abivax 91.96 Bn 91.96 Bn - -45.97 Mn
10 Ionis Pharmaceuticals 12.23 Bn 10.31 Bn 243.11 Mn -198.88 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -198.88 Mn
Dec 31, 2025 33.92 Mn
Sep 30, 2025 41.04 Mn
Jun 30, 2025 33.11 Mn
Mar 31, 2025 22.12 Mn
Dec 31, 2024 -92.53 Mn
Sep 30, 2024 40.61 Mn
Jun 30, 2024 -54.90 Mn
Mar 31, 2024 -50.38 Mn
Dec 31, 2023 47.21 Mn
Sep 30, 2023 -72.73 Mn
Jun 30, 2023 115.76 Mn
Mar 31, 2023 32.56 Mn
Dec 31, 2022 -38.52 Mn
Sep 30, 2022 -206.92 Mn
Jun 30, 2022 -20.60 Mn
Mar 31, 2022 -326.68 Mn
Dec 31, 2021 236.24 Mn
Sep 30, 2021 67.83 Mn
Jun 30, 2021 150.96 Mn