Ionis Pharmaceuticals (IONS) Cash from Operations (2009 - 2026)

Ionis Pharmaceuticals' (IONS) quarterly Cash from Operations came in at 792819000.0 in Q1 2026, down 425.83% year-on-year from 243323484.13 in Q1 2025, and down 475.72% quarter-over-quarter from 137709000.0 in Q4 2025.

Ionis Pharmaceuticals (IONS) Cash from Operations (2009 - 2026) Analysis & Trends

Ionis Pharmaceuticals' Cash from Operations history runs 18 years deep, the most recent figure standing at 792819000.0 for Q1 2026.

  • On a quarterly basis, Cash from Operations fell 425.83% year-over-year to 792819000.0 in Q1 2026; TTM through Mar 2026 was 910627000.0, a 81.48% decrease from a year earlier, with the FY2025 full-year figure at 268583000.0, up 46.38% from the prior year.
  • Cash from Operations declined to 792819000.0 in Q1 2026 per IONS's latest filing, from 137709000.0 in the prior quarter.
  • Across five years, Cash from Operations topped out at 151338000.0 in Q2 2025 and bottomed at 792819000.0 in Q1 2026.
  • The 5-year median for Cash from Operations is 116139000.0 (2024), against an average of 126131294.12.
  • Across the five-year window, Cash from Operations slumped 453.38% in 2024 and jumped 226.24% in 2025, its largest moves.
  • Year by year, Cash from Operations stood at 200195000.0 in 2022, then soared by 116.42% to 32865000.0 in 2023, then slumped by 453.38% to 116139000.0 in 2024, then retreated by 18.57% to 137709000.0 in 2025, then plunged by 475.72% to 792819000.0 in 2026.
  • Per Business Quant, the three latest IONS Cash from Operations figures stand at 792819000.0 (Q1 2026), 137709000.0 (Q4 2025), and 131437000.0 (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Cash from Operations (Qtr)
1 Oculis Holding AG 67,072.09 Bn 67,072.09 Bn - -19.59 Mn
2 Nanobiotix 1,894.61 Bn 1,894.55 Bn - -
3 Akari Therapeutics 1,014.18 Bn 1,014.18 Bn - -2.49 Mn
4 BeOne Medicines 471.64 Bn 466.85 Bn 1.35 Bn 201.34 Mn
5 Vertex Pharmaceuticals 121.72 Bn 114.47 Bn 2.59 Bn 1.43 Bn
6 Regeneron Pharmaceuticals 68.28 Bn 59.52 Bn 3.31 Bn 1.08 Bn
7 Belite Bio 61.40 Bn 61.40 Bn - -
8 Argenx Se 56.94 Bn 56.94 Bn 1.18 Bn -
9 Revolution Medicines 37.37 Bn 37.37 Bn - -354.17 Mn
10 Ionis Pharmaceuticals 9.35 Bn 7.43 Bn 243.11 Mn -792.82 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -792.82 Mn
Mar 31, 2026 -792.82 Mn
Dec 31, 2025 -137.71 Mn
Dec 31, 2025 -137.71 Mn
Sep 30, 2025 -131.44 Mn
Sep 30, 2025 -131.44 Mn
Jun 30, 2025 151.34 Mn
Jun 30, 2025 151.34 Mn
Mar 31, 2025 -150.78 Mn
Mar 31, 2025 -150.78 Mn
Dec 31, 2024 -116.14 Mn
Dec 31, 2024 -116.14 Mn
Sep 30, 2024 -114.99 Mn
Sep 30, 2024 -114.99 Mn
Jun 30, 2024 -119.88 Mn
Jun 30, 2024 -119.88 Mn
Mar 31, 2024 -149.94 Mn
Mar 31, 2024 -149.94 Mn
Dec 31, 2023 32.87 Mn
Dec 31, 2023 32.87 Mn