Structure Therapeutics (GPCR) EBITDA (2022 - 2026)
Quarterly EBITDA fell 68.79% to -$79.2 million in Q1 2026 from the year-ago period, while the trailing twelve-month figure was -$173.3 million through Mar 2026, down 21.72% year-over-year, with the annual reading at -$141.1 million for FY2025, 15.5% down from the prior year.
Structure Therapeutics' EBITDA history spans 5 years, with the latest figure at -$79.2 million for Q1 2026.
- EBITDA came in at -$79.2 million for Q1 2026, down from $33.2 million in the prior quarter.
- In the past five years, EBITDA ranged from a high of $33.2 million in Q4 2025 to a low of -$79.2 million in Q1 2026.
- The 5-year median for EBITDA is -$23.8 million (2023), against an average of -$28.4 million.
- The largest YoY upside for EBITDA was 186.54% in 2025 against a maximum downside of 135.0% in 2025.
- Structure Therapeutics' EBITDA stood at -$11.8 million in 2022, then crashed by 99.76% to -$23.7 million in 2023, then tumbled by 62.23% to -$38.4 million in 2024, then surged by 186.54% to $33.2 million in 2025, then crashed by 338.37% to -$79.2 million in 2026.
- Per Business Quant, the three most recent readings for GPCR's EBITDA are -$79.2 million (Q1 2026), $33.2 million (Q4 2025), and -$65.2 million (Q3 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,384,976.65 Bn | 1,384,976.64 Bn | - | -13.63 Mn |
| 2 | Alterity Therapeutics | 777,208.84 Bn | 777,208.81 Bn | - | - |
| 3 | Legend Biotech | 2,801.00 Bn | 2,800.10 Bn | 242.10 Mn | -19.70 Mn |
| 4 | Nanobiotix | 2,226.01 Bn | 2,225.95 Bn | - | - |
| 5 | Akari Therapeutics | 605.66 Bn | 605.66 Bn | - | -14.44 Mn |
| 6 | Vertex Pharmaceuticals | 110.17 Bn | 102.92 Bn | 2.59 Bn | 1.14 Bn |
| 7 | Regeneron Pharmaceuticals | 66.86 Bn | 58.11 Bn | 3.31 Bn | 661.60 Mn |
| 8 | Evaxion A | 65.12 Bn | 65.10 Bn | - | -3.82 Mn |
| 9 | Alnylam Pharmaceuticals | 39.94 Bn | 36.94 Bn | 959.66 Mn | 201.19 Mn |
| 10 | Structure Therapeutics | 8.43 Bn | 8.43 Bn | - | -79.22 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -79.22 Mn |
| Dec 31, 2025 | 33.23 Mn |
| Sep 30, 2025 | -65.25 Mn |
| Jun 30, 2025 | -62.11 Mn |
| Mar 31, 2025 | -46.93 Mn |
| Dec 31, 2024 | -38.40 Mn |
| Sep 30, 2024 | -30.65 Mn |
| Jun 30, 2024 | -26.43 Mn |
| Mar 31, 2024 | -26.65 Mn |
| Dec 31, 2023 | -23.67 Mn |
| Sep 30, 2023 | -23.78 Mn |
| Jun 30, 2023 | -23.82 Mn |
| Mar 31, 2023 | -17.72 Mn |
| Dec 31, 2022 | -11.85 Mn |
| Sep 30, 2022 | -12.47 Mn |
| Jun 30, 2022 | -14.00 Mn |
| Mar 31, 2022 | -13.12 Mn |