Structure Therapeutics (GPCR) EBITDA (2022 - 2026)
Structure Therapeutics' (GPCR) quarterly EBITDA came in at -$89.4 million in Q1 2026, down 58.72% year-on-year from -$216.5 million in Q1 2025, and down 472.58% quarter-over-quarter from $24.0 million in Q4 2025.
Structure Therapeutics (GPCR) EBITDA (2022 - 2026) Analysis & Trends
Structure Therapeutics' EBITDA history runs 5 years deep, the most recent figure standing at -$89.4 million for Q1 2026.
- On a quarterly basis, EBITDA fell 58.72% year-over-year to -$89.4 million in Q1 2026; TTM through Mar 2026 was -$209.6 million, a 14.85% decrease from a year earlier, with the FY2025 full-year figure at -$176.6 million, down 11.59% from the prior year.
- EBITDA retreated to -$89.4 million in Q1 2026 per GPCR's latest filing, from $24.0 million in the prior quarter.
- Across five years, EBITDA topped out at $24.0 million in Q4 2025 and bottomed at -$89.4 million in Q1 2026.
- The 5-year median for EBITDA is -$31.0 million (2023), against an average of -$34.1 million.
- Across the five-year window, EBITDA tumbled 139.23% in 2023 and soared 150.97% in 2025, its largest moves.
- Year by year, EBITDA stood at -$13.0 million in 2022, then tumbled by 139.23% to -$31.0 million in 2023, then slumped by 51.84% to -$47.1 million in 2024, then surged by 150.97% to $24.0 million in 2025, then sank by 472.58% to -$89.4 million in 2026.
- Per Business Quant, the three latest GPCR EBITDA figures stand at -$89.4 million (Q1 2026), $24.0 million (Q4 2025), and -$73.8 million (Q3 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | -27.75 Mn |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 249.90 Mn |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | -3.72 Mn |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 1.14 Bn |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 642.90 Mn |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | -32.68 Mn |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | 493.00 Mn |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | -445.22 Mn |
| 10 | Structure Therapeutics | 11.04 Bn | 11.04 Bn | - | -89.38 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -89.38 Mn |
| Dec 31, 2025 | 23.99 Mn |
| Sep 30, 2025 | -73.79 Mn |
| Jun 30, 2025 | -70.45 Mn |
| Mar 31, 2025 | -56.31 Mn |
| Dec 31, 2024 | -47.06 Mn |
| Sep 30, 2024 | -45.84 Mn |
| Jun 30, 2024 | -33.32 Mn |
| Mar 31, 2024 | -32.02 Mn |
| Dec 31, 2023 | -30.99 Mn |
| Sep 30, 2023 | -26.15 Mn |
| Jun 30, 2023 | -25.99 Mn |
| Mar 31, 2023 | -19.65 Mn |
| Dec 31, 2022 | -12.96 Mn |
| Sep 30, 2022 | -12.69 Mn |
| Jun 30, 2022 | -13.96 Mn |
| Mar 31, 2022 | -12.95 Mn |