Design Therapeutics (DSGN) Return on Capital Employed (2021 - 2026)

Design Therapeutics' (DSGN) quarterly Return on Capital Employed came in at 36.1% in Q1 2026, down 719.0% year-on-year from 5.83% in Q1 2025, and up 6.44% quarter-over-quarter from 38.59% in Q4 2025.

Design Therapeutics (DSGN) Return on Capital Employed (2021 - 2026) Analysis & Trends

Design Therapeutics has disclosed Return on Capital Employed across 6 years of filings, most recently posting 36.1% for Q1 2026.

  • Return on Capital Employed for Q1 2026 came in at 36.1%, down 719.0% year-over-year; the trailing twelve-month figure through Mar 2026 was 36.1% (down 719.0% YoY), and the FY2025 annual result was 35.15%, down 1137.0% from the prior year.
  • Return on Capital Employed came in at 36.1% for Q1 2026 at Design Therapeutics, up from 38.59% in the prior quarter.
  • In the past five years, Return on Capital Employed ranged from a high of 11.48% in Q1 2022 to a low of 38.59% in Q4 2025.
  • The 5-year median for Return on Capital Employed is 25.6% (2024), against an average of 25.98%.
  • Across the five-year window, Return on Capital Employed surged 456 bps in 2024 and slumped 1428 bps in 2025, its largest moves.
  • Design Therapeutics' Return on Capital Employed stood at 20.05% in 2022, then plunged by 37 bps to 27.42% in 2023, then advanced by 8 bps to 25.11% in 2024, then tumbled by 54 bps to 38.59% in 2025, then climbed by 6 bps to 36.1% in 2026.
  • The last three Return on Capital Employed figures came in at 36.1% (Q1 2026), 38.59% (Q4 2025), and 37.83% (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) ROCE (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - 450.31%
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn 51.73%
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -107.40%
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 21.10%
9 Abivax 91.96 Bn 91.96 Bn - -50.43%
10 Design Therapeutics 763.94 Mn 541.11 Mn - -36.10%

Historic Data

Download Data
DateValue
Mar 31, 2026 -36.10%
Dec 31, 2025 -38.59%
Sep 30, 2025 -37.83%
Jun 30, 2025 -33.84%
Mar 31, 2025 -28.92%
Dec 31, 2024 -25.11%
Sep 30, 2024 -23.55%
Jun 30, 2024 -23.67%
Mar 31, 2024 -25.60%
Dec 31, 2023 -27.42%
Sep 30, 2023 -28.11%
Jun 30, 2023 -27.06%
Mar 31, 2023 -23.43%
Dec 31, 2022 -20.05%
Sep 30, 2022 -16.91%
Jun 30, 2022 -14.06%
Mar 31, 2022 -11.48%
Dec 31, 2021 -9.18%
Sep 30, 2021 -7.19%
Jun 30, 2021 -4.84%