Design Therapeutics, Inc. (DSGN) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

56,656,667Shares Outstanding

6,621,153Shares held by institutions

$67,006,068Value of institutional holdings

67.32%Institutional ownership %

13.79%Shares Changed QoQ

111No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

According to SEC filings for the period ending December 2025, Design Therapeutics, Inc. (NASDAQ:DSGN) is held by 111 institutional firms.

The percentage of Design Therapeutics owned by institutions changed from 63.6% in September 2025 to 67.3% in December 2025, marking a slight up trend.
In percentage terms, this reflects as a holdings change of 13.79% quarter on quarter, and an increase of 15.62% year over year.
A review of institutional activity for Design Therapeutics shows 66 of 111 filers increasing their positions, while 28 reduced their stake, and 17 remained unchanged.
This class of investors increased its holdings in Design Therapeutics to 38.14Mn shares for the 13F-cycle ending December 2025, up by 4.62Mn shares quarter on quarter, and up 4.68Mn shares year over year.
The top institutional stake in Design Therapeutics as of December 31, 2025 belongs to SR ONE CAPITAL MANAGEMENT, LP, which owns 6.53Mn shares, or 11.52% of the company.
Among the most significant buyers of Design Therapeutics during December 2025 were Point72 Asset Management, L.P. (2.03Mn), Vivo Capital, LLC (1.61Mn), RA CAPITAL MANAGEMENT, L.P. (985.68K), MORGAN STANLEY (526.32K), BAKER BROS. ADVISORS LP (520.22K).
Leading sellers of Design Therapeutics stock in December 2025 included Almitas Capital LLC (1.53Mn), Frazier Life Sciences Management, L.P. (1.43Mn), Logos Global Management LP (1.16Mn), Kynam Capital Management, LP (244.97K), BRIDGEWAY CAPITAL MANAGEMENT, LLC (109.70K).
The top 10 institutional holders of Design Therapeutics for the quarter ending December 2025 included SR ONE CAPITAL MANAGEMENT, LP (6.53Mn), Point72 Asset Management, L.P. (5.37Mn), Logos Global Management LP (2.50Mn), BAKER BROS. ADVISORS LP (2.23Mn), BlackRock, Inc. (2.12Mn), VANGUARD GROUP INC (1.63Mn), Vivo Capital, LLC (1.61Mn), Almitas Capital LLC (1.53Mn), RA CAPITAL MANAGEMENT, L.P. (1.46Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (1.18Mn).

111 Institutional Holders

6,621,153 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
SR ONE CAPITAL MANAGEMENT, LP	31 Dec, 2025	6,526,476	0	0.00%	$61,218,345.00
Point72 Asset Management, L.P.	31 Dec, 2025	5,372,004	2,031,452	60.81%	$50,389,398.00
Logos Global Management LP	31 Dec, 2025	2,500,000	-1,155,000	-31.60%	$23,450,000.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	2,233,099	520,217	30.37%	$20,946,469.00
BlackRock, Inc.	31 Dec, 2025	2,117,156	72,768	3.56%	$19,858,924.00
VANGUARD GROUP INC	31 Dec, 2025	1,630,910	187,209	12.97%	$15,297,936.00
Vivo Capital, LLC	31 Dec, 2025	1,612,903	1,612,903	0.00%	$15,129,030.00
Almitas Capital LLC	31 Dec, 2025	1,530,435	-1,530,435	-50.00%	$14,355,480.00
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	1,461,381	985,682	207.21%	$13,707,754.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	1,179,817	103,581	9.62%	$11,066,683.00
Woodline Partners LP	31 Dec, 2025	944,039	331,327	54.08%	$8,855,086.00
Kynam Capital Management, LP	31 Dec, 2025	784,606	-244,973	-23.79%	$7,359,604.00
FMR LLC	31 Dec, 2025	771,268	30,419	4.11%	$7,234,494.00
MORGAN STANLEY	31 Dec, 2025	702,306	526,315	299.06%	$6,587,630.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	679,590	-16,023	-2.30%	$6,375,975.00
STATE STREET CORP	31 Dec, 2025	647,636	13,239	2.09%	$6,074,826.00
ACADIAN ASSET MANAGEMENT LLC	31 Dec, 2025	612,768	-4,721	-0.76%	$5,742.00
Frazier Life Sciences Management, L.P.	31 Dec, 2025	521,000	-1,432,547	-73.33%	$4,886,980.00
Caption Management, LLC	31 Dec, 2025	500,000	500,000	0.00%	$4,690,000.00
CITADEL ADVISORS LLC	31 Dec, 2025	459,874	-94,146	-16.99%	$4,313,618.00

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