Design Therapeutics, Inc. (DSGN) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

0Shares Outstanding

12,803,837Shares held by institutions

$132,775,790Value of institutional holdings

59.30%Institutional ownership %

-5.37%Shares Changed QoQ

91No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Design Therapeutics, Inc. (NASDAQ:DSGN) has 114 institutional investors that have filed 13F reports for the period ending December 2025.

They owned 66.9% of outstanding stock in December 2025, up from 63.4% the prior quarter.
Their total shares held in DSGN increased 13.52% quarter over quarter, and separately, investors owning Design Therapeutics increased 18.75% from a year ago.
Among the 114 funds, 68 bought more Design Therapeutics shares, 29 sold down, and 17 held their ground.
Institutional investors collectively held 38.12Mn shares in Design Therapeutics as of December 2025, up by 4.54Mn shares quarter on quarter, and up 4.23Mn shares year over year.
SR ONE CAPITAL MANAGEMENT, LP holds the largest position in DSGN at 6.53Mn shares as of December 31, 2025, or 11.46% of shares outstanding.
The most significant purchases of DSGN for the quarter ending December 2025 came from Point72 Asset Management, L.P. (2.03Mn), Vivo Capital, LLC (1.61Mn), RA CAPITAL MANAGEMENT, L.P. (985.68K), Morgan Stanley (526.32K), BAKER BROS. ADVISORS LP (520.22K).
Leading sellers of Design Therapeutics shares for the quarter ending December 2025 were Almitas Capital LLC (1.53Mn), Frazier Life Sciences Management, L.P. (1.43Mn), Logos Global Management LP (1.16Mn), Kynam Capital Management, LP (244.97K), BRIDGEWAY CAPITAL MANAGEMENT, LLC (109.7K).
According to Business Quant data, leading holders of DSGN for December 2025 are SR ONE CAPITAL MANAGEMENT, LP (6.53Mn), Point72 Asset Management, L.P. (5.37Mn), Logos Global Management LP (2.5Mn), BAKER BROS. ADVISORS LP (2.23Mn), BlackRock, Inc. (2.12Mn), VANGUARD GROUP INC (1.63Mn), Vivo Capital, LLC (1.61Mn), Almitas Capital LLC (1.53Mn), RA CAPITAL MANAGEMENT, L.P. (1.46Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (1.18Mn).

114 Institutional Holders

12,803,837 Total Shares Held

Rows:

Download Data

Owner Name	Date	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	72,768	3.56%	$0.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	520,217	30.37%	$0.00
SR ONE CAPITAL MANAGEMENT, LP	31 Dec, 2025	0	0.00%	$0.00
Barclays Plc	31 Dec, 2025	-97,751	-52.89%	$0.00
VANGUARD GROUP INC	31 Dec, 2025	187,209	12.97%	$0.00
Point72 Asset Management, L.P.	31 Dec, 2025	2,031,452	60.81%	$0.00
Rockefeller Capital Management L.P.	31 Dec, 2025	1,476	0.00%	$0.00
Almitas Capital LLC	31 Dec, 2025	-1,530,435	-50.00%	$0.00
Logos Global Management LP	31 Dec, 2025	-1,155,000	-31.60%	$0.00
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	985,682	207.21%	$0.00
Vivo Capital, LLC	31 Dec, 2025	1,612,903	0.00%	$0.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	103,581	9.62%	$0.00
Woodline Partners LP	31 Dec, 2025	331,327	54.08%	$0.00
FMR LLC	31 Dec, 2025	30,419	4.11%	$0.00
Kynam Capital Management, LP	31 Dec, 2025	-244,973	-23.79%	$0.00
Morgan Stanley	31 Dec, 2025	526,315	299.06%	$0.00
Frazier Life Sciences Management, L.P.	31 Dec, 2025	-1,432,547	-73.33%	$0.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	-16,023	-2.30%	$0.00
Elmind Capital, LP	31 Dec, 2025	207,900	0.00%	$0.00
State Street Corp	31 Dec, 2025	13,239	2.09%	$0.00

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