Cue Biopharma (CUE) Net Margin (2018 - 2025)

Cue Biopharma's (CUE) quarterly Net Margin came in at 244.28% in Q4 2025, down 125419.0% year-on-year from N/an in Q4 2024, and up 171.2% quarter-over-quarter from 343.09% in Q3 2025.

Cue Biopharma (CUE) Net Margin (2018 - 2025) Analysis & Trends

Cue Biopharma has disclosed Net Margin across 8 years of filings, most recently posting 244.28% for Q4 2025.

  • Net Margin for Q4 2025 came in at 244.28%, down 125419.0% year-over-year; the trailing twelve-month figure through Dec 2025 was 31.5% (up 4299.0% YoY), and the FY2025 annual result was 18.84%, up 5566.0% from the prior year.
  • Net Margin came in at 244.28% for Q4 2025 at Cue Biopharma, up from 343.09% in the prior quarter.
  • In the past five years, Net Margin ranged from a high of 1498.48% in Q4 2024 to a low of 50800.0% in Q2 2022.
  • The 5-year median for Net Margin is 623.79% (2021), against an average of 4582.56%.
  • Across the five-year window, Net Margin sank 5042472 bps in 2022 and surged 4986274 bps in 2023, its largest moves.
  • Cue Biopharma's Net Margin stood at 95.58% in 2021, then tumbled by 9763 bps to 9426.49% in 2022, then jumped by 92 bps to 709.88% in 2023, then surged by 311 bps to 1498.48% in 2024, then plunged by 84 bps to 244.28% in 2025.
  • The last three Net Margin figures came in at 244.28% (Q4 2025), 343.09% (Q3 2025), and 285.61% (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Net Margin (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn 0.82%
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 34.53%
9 Abivax 91.96 Bn 91.96 Bn - -
10 Cue Biopharma 581.16 Mn 553.47 Mn - 244.28%

Historic Data

Download Data
DateValue
Dec 31, 2025 244.28%
Sep 30, 2025 -343.09%
Jun 30, 2025 -285.61%
Mar 31, 2025 -2,881.00%
Dec 31, 2024 1,498.48%
Sep 30, 2024 -253.96%
Jun 30, 2024 -374.57%
Mar 31, 2024 -705.07%
Dec 31, 2023 -709.88%
Sep 30, 2023 -510.43%
Jun 30, 2023 -937.26%
Mar 31, 2023 -6,812.30%
Dec 31, 2022 -9,426.49%
Sep 30, 2022 -16,110.29%
Jun 30, 2022 -50,800.00%
Mar 31, 2022 -1,425.50%
Dec 31, 2021 -95.58%
Sep 30, 2021 -542.51%
Jun 30, 2021 -375.28%
Mar 31, 2021 -805.22%