Cue Biopharma (CUE) Net Margin (2018 - 2025)
Cue Biopharma's (CUE) quarterly Net Margin came in at 244.28% in Q4 2025, down 125419.0% year-on-year from N/an in Q4 2024, and up 171.2% quarter-over-quarter from 343.09% in Q3 2025.
Cue Biopharma (CUE) Net Margin (2018 - 2025) Analysis & Trends
Cue Biopharma has disclosed Net Margin across 8 years of filings, most recently posting 244.28% for Q4 2025.
- Net Margin for Q4 2025 came in at 244.28%, down 125419.0% year-over-year; the trailing twelve-month figure through Dec 2025 was 31.5% (up 4299.0% YoY), and the FY2025 annual result was 18.84%, up 5566.0% from the prior year.
- Net Margin came in at 244.28% for Q4 2025 at Cue Biopharma, up from 343.09% in the prior quarter.
- In the past five years, Net Margin ranged from a high of 1498.48% in Q4 2024 to a low of 50800.0% in Q2 2022.
- The 5-year median for Net Margin is 623.79% (2021), against an average of 4582.56%.
- Across the five-year window, Net Margin sank 5042472 bps in 2022 and surged 4986274 bps in 2023, its largest moves.
- Cue Biopharma's Net Margin stood at 95.58% in 2021, then tumbled by 9763 bps to 9426.49% in 2022, then jumped by 92 bps to 709.88% in 2023, then surged by 311 bps to 1498.48% in 2024, then plunged by 84 bps to 244.28% in 2025.
- The last three Net Margin figures came in at 244.28% (Q4 2025), 343.09% (Q3 2025), and 285.61% (Q2 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | - |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | 0.82% |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | - |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | - |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 34.53% |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | - |
| 10 | Cue Biopharma | 581.16 Mn | 553.47 Mn | - | 244.28% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 244.28% |
| Sep 30, 2025 | -343.09% |
| Jun 30, 2025 | -285.61% |
| Mar 31, 2025 | -2,881.00% |
| Dec 31, 2024 | 1,498.48% |
| Sep 30, 2024 | -253.96% |
| Jun 30, 2024 | -374.57% |
| Mar 31, 2024 | -705.07% |
| Dec 31, 2023 | -709.88% |
| Sep 30, 2023 | -510.43% |
| Jun 30, 2023 | -937.26% |
| Mar 31, 2023 | -6,812.30% |
| Dec 31, 2022 | -9,426.49% |
| Sep 30, 2022 | -16,110.29% |
| Jun 30, 2022 | -50,800.00% |
| Mar 31, 2022 | -1,425.50% |
| Dec 31, 2021 | -95.58% |
| Sep 30, 2021 | -542.51% |
| Jun 30, 2021 | -375.28% |
| Mar 31, 2021 | -805.22% |