Growth Metrics

Calidi Biotherapeutics (CLDI) Research & Development (2022 - 2025)

Calidi Biotherapeutics' quarterly Research & Development came in at $2.4 million in Q4 2025, up 29.92% year-on-year from $1.8 million in Q4 2024, and little changed quarter-over-quarter from $2.4 million in Q3 2025.

Calidi Biotherapeutics has reported Research & Development for 4 years, with the latest figure at $2.4 million in Q4 2025.

  • For the quarter ending Q4 2025, Research & Development rose 29.92% year-over-year to $2.4 million; the trailing twelve-month figure through Dec 2025 stood at $9.7 million (up 9.68% YoY), and the FY2025 full-year result was $9.7 million, up 9.68% from the prior year.
  • Research & Development for Q4 2025 stood at $2.4 million, roughly flat from $2.4 million in the prior quarter.
  • The five-year high for Research & Development was $4.0 million in Q4 2023, with the low at $1.8 million in Q4 2024.
  • Average Research & Development over 4 years is $2.6 million, with a median of $2.4 million recorded in 2025.
  • Year-over-year, Research & Development soared 74.9% in 2023 and slumped 54.14% in 2024.
  • Tracing CLDI's Research & Development over 4 years: stood at $2.3 million in 2022, then soared by 74.9% to $4.0 million in 2023, then tumbled by 54.14% to $1.8 million in 2024, then advanced by 29.92% to $2.4 million in 2025.
  • The last three Research & Development figures came in at $2.4 million (Q4 2025), $2.4 million (Q3 2025), and $2.6 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) R&D (Qtr)
1 Quantum Biopharma 1,638,563.89 Bn 1,638,563.89 Bn - 626,092.00
2 Alterity Therapeutics 767,934.24 Bn 767,934.20 Bn - 4.32 Mn
3 Legend Biotech 2,937.00 Bn 2,936.10 Bn 242.10 Mn -101.30 Mn
4 Nanobiotix 2,282.79 Bn 2,282.72 Bn - -
5 Akari Therapeutics 2,169.69 Bn 2,169.69 Bn - 1.46 Mn
6 Vertex Pharmaceuticals 110.41 Bn 103.16 Bn 2.59 Bn 961.60 Mn
7 Regeneron Pharmaceuticals 66.44 Bn 57.69 Bn 3.31 Bn 1.54 Bn
8 Evaxion A 65.44 Bn 65.42 Bn - -2.30 Mn
9 Alnylam Pharmaceuticals 39.53 Bn 36.52 Bn 959.66 Mn 364.87 Mn
10 Calidi Biotherapeutics - - - 2.36 Mn

Historic Data

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DateValue
Dec 31, 2025 2.36 Mn
Sep 30, 2025 2.36 Mn
Jun 30, 2025 2.59 Mn
Mar 31, 2025 2.43 Mn
Dec 31, 2024 1.82 Mn
Sep 30, 2024 2.15 Mn
Jun 30, 2024 2.17 Mn
Mar 31, 2024 2.74 Mn
Dec 31, 2023 3.96 Mn
Sep 30, 2023 3.25 Mn
Jun 30, 2023 3.18 Mn
Mar 31, 2023 2.62 Mn
Dec 31, 2022 2.26 Mn
Sep 30, 2022 1.95 Mn