Calidi Biotherapeutics (CLDI) Operating Income (2022 - 2026)
Calidi Biotherapeutics (CLDI) posted quarterly Operating Income of -$4.5 million for Q4 2025, down 10.93% year-over-year from -$5.0 million in Q4 2024, and up 11.53% quarter-over-quarter from -$5.0 million in Q3 2025.
Calidi Biotherapeutics (CLDI) Operating Income (2022 - 2026) Analysis & Trends
Calidi Biotherapeutics' Operating Income history runs 4 years deep, the most recent figure standing at -$4.5 million for Q4 2025.
- In Q4 2025, Operating Income fell 10.93% year-over-year to -$4.5 million; the TTM figure through Dec 2025 stood at -$20.2 million (up 7.05% YoY), while the FY2025 annual figure was -$20.2 million, up 7.05% from the prior year.
- Operating Income for Q4 2025 stood at -$4.5 million, up from -$5.0 million in the prior quarter.
- The five-year high for Operating Income was -$361622.0 in Q2 2022, with the low at -$9.8 million in Q4 2023.
- The 4-year median for Operating Income is -$5.3 million (2023), against an average of -$5.2 million.
- The sharpest annual moves came in 2023 and 2024: Operating Income tumbled 1707.69% in 2023, then jumped 59.0% in 2024.
- Calidi Biotherapeutics' Operating Income stood at -$4.7 million in 2022, then plunged by 109.47% to -$9.8 million in 2023, then surged by 59.0% to -$4.0 million in 2024, then decreased by 10.93% to -$4.5 million in 2025.
- Business Quant data shows CLDI's Operating Income at -$4.5 million in Q4 2025, -$5.0 million in Q3 2025, and -$5.7 million in Q2 2025.
Powered by 
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Op. Inc (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 138.92 Bn | 131.07 Bn | 2.84 Bn | 1.25 Bn |
| 2 | Regeneron Pharmaceuticals | 85.91 Bn | 77.91 Bn | 3.93 Bn | 1.29 Bn |
| 3 | Argenx Se | 64.87 Bn | 59.68 Bn | 1.37 Bn | 493.00 Mn |
| 4 | Moderna | 58.18 Bn | 53.04 Bn | 52.00 Mn | -815.00 Mn |
| 5 | BeOne Medicines | 41.96 Bn | 36.87 Bn | 1.53 Bn | 325.05 Mn |
| 6 | Alnylam Pharmaceuticals | 31.53 Bn | 28.23 Bn | 992.69 Mn | 231.44 Mn |
| 7 | BioNTech SE | 27.79 Bn | 9.40 Bn | 668.28 Mn | -375.75 Mn |
| 8 | Insmed | 27.46 Bn | 26.30 Bn | 358.27 Mn | -1.55 Mn |
| 9 | Royalty Pharma | 27.37 Bn | 26.53 Bn | - | 133.12 Mn |
| 10 | Calidi Biotherapeutics | 1.88 Mn | -2.22 Mn | - | -4.15 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Jun 30, 2026 | -4.15 Mn |
| Dec 31, 2025 | -4.47 Mn |
| Sep 30, 2025 | -5.05 Mn |
| Jun 30, 2025 | -5.66 Mn |
| Mar 31, 2025 | -5.06 Mn |
| Dec 31, 2024 | -4.03 Mn |
| Sep 30, 2024 | -5.23 Mn |
| Jun 30, 2024 | -5.77 Mn |
| Mar 31, 2024 | -6.75 Mn |
| Dec 31, 2023 | -9.82 Mn |
| Sep 30, 2023 | -7.22 Mn |
| Jun 30, 2023 | -6.54 Mn |
| Mar 31, 2023 | -5.41 Mn |
| Dec 31, 2022 | -4.69 Mn |
| Sep 30, 2022 | -6.99 Mn |
| Jun 30, 2022 | -361,622.00 |
| Mar 31, 2022 | -528,858.00 |