Growth Metrics

BioNTech SE (BNTX) Change in Cash (2018 - 2025)

BioNTech SE (BNTX) posted Change in Cash of -$2.8 billion for Q4 2025, down 1450.28% on a QoQ basis from -$182.5 million in Q3 2025, and down 2045.25% year-over-year from $145.4 million in Q4 2024.

BioNTech SE (BNTX) has 8 years of Change in Cash data on file, last reported at -$2.8 billion in Q4 2025.

  • In Q4 2025, Change in Cash fell 2045.25% year-over-year to -$2.8 billion; the TTM figure through Dec 2025 stood at -$2.5 billion (down 16.5% YoY), while the FY2025 annual figure was -$2.3 billion, down 13.77% from the prior year.
  • Change in Cash eased to -$2.8 billion in Q4 2025, from -$182.5 million in the prior quarter.
  • Across five years, Change in Cash topped out at $5.0 billion in Q1 2022 and bottomed at -$2.9 billion in Q1 2024.
  • A 5-year average of $356.8 million and a median of $52.7 million in 2021 frame the typical range for Change in Cash.
  • Annual changes were most pronounced in 2022 — Change in Cash surged 1194599910.37% — and 2025, when it sank 2045.25%.
  • Year by year, Change in Cash stood at -$818.4 in 2021, then surged by 75234909.21% to $615.7 million in 2022, then plunged by 424.52% to -$2.0 billion in 2023, then jumped by 107.28% to $145.4 million in 2024, then sank by 2045.25% to -$2.8 billion in 2025.
  • The last three Change in Cash figures came in at -$2.8 billion (Q4 2025), -$182.5 million (Q3 2025), and $77.9 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Change in Cash (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - 2.44 Mn
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - -
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn 623.00 Mn
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - -2.44 Mn
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 417.10 Mn
7 Evaxion A 62.56 Bn 62.54 Bn - -
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn -153.10 Mn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 53.61 Mn
10 BioNTech SE 27.66 Bn 7.53 Bn 668.28 Mn -2.83 Bn

Historic Data

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DateValue
Dec 31, 2025 -2.83 Bn
Sep 30, 2025 -182.49 Mn
Jun 30, 2025 77.88 Mn
Mar 31, 2025 475.77 Mn
Dec 31, 2024 145.44 Mn
Sep 30, 2024 -866.39 Mn
Jun 30, 2024 1.47 Bn
Mar 31, 2024 -2.86 Bn
Dec 31, 2023 -2.00 Bn
Sep 30, 2023 -796.85 Mn
Jun 30, 2023 2.10 Bn
Mar 31, 2023 -1.83 Bn
Dec 31, 2022 615.72 Mn
Sep 30, 2022 4.08 Bn
Jun 30, 2022 3.26 Bn
Mar 31, 2022 4.96 Bn
Dec 31, 2021 -818.40
Sep 30, 2021 1.28 Bn
Jun 30, 2021 27.46 Mn
Mar 31, 2021 -415.07
Dec 31, 2020 316.79
Mar 31, 2020 -74.63 Mn
Dec 31, 2019 61.80 Mn
Dec 31, 2018 -206.39 Mn