Bicycle Therapeutics (BCYC) Net Cash Flow (2018 - 2026)

Bicycle Therapeutics (BCYC) reported Net Cash Flow of -$66.7 million for Q1 2026, up 23.36% on a YoY basis from -$54.1 million in Q1 2025, and down 234.55% quarter-over-quarter from -$19.9 million in Q4 2025.

Bicycle Therapeutics (BCYC) Net Cash Flow (2018 - 2026) Analysis & Trends

Bicycle Therapeutics has reported Net Cash Flow for 9 years, with the latest figure at -$66.7 million in Q1 2026.

  • For the quarter ending Q1 2026, Net Cash Flow rose 23.36% year-over-year to -$66.7 million; the trailing twelve-month figure through Mar 2026 stood at -$231.8 million (down 169.04% YoY), and the FY2025 full-year result was -$252.2 million, down 171.27% from the prior year.
  • Net Cash Flow for Q1 2026 stood at -$66.7 million, down from -$19.9 million in the prior quarter.
  • The five-year high for Net Cash Flow was $504.6 million in Q2 2024, with the low at -$87.0 million in Q1 2025.
  • Historically, Net Cash Flow has averaged $7.2 million across 5 years, with a median of -$33.1 million in 2022.
  • Annual changes were most pronounced in 2022 — Net Cash Flow plunged 1200.46% — and 2023, when it surged 2780.59%.
  • Bicycle Therapeutics' Net Cash Flow stood at -$25.9 million in 2022, then slumped by 81.5% to -$47.0 million in 2023, then surged by 79.64% to -$9.6 million in 2024, then plunged by 108.5% to -$19.9 million in 2025, then slumped by 234.55% to -$66.7 million in 2026.
  • The last three Net Cash Flow figures came in at -$66.7 million (Q1 2026), -$19.9 million (Q4 2025), and -$71.9 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Net Cash Flow (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - 2.44 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn 625.70 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -2.44 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 457.40 Mn
9 Abivax 91.96 Bn 91.96 Bn - 664,983.53
10 Bicycle Therapeutics 278.04 Mn 278.04 Mn - -66.69 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -66.69 Mn
Mar 31, 2026 -66.69 Mn
Dec 31, 2025 -19.94 Mn
Dec 31, 2025 -19.94 Mn
Sep 30, 2025 -71.88 Mn
Sep 30, 2025 -71.88 Mn
Jun 30, 2025 -73.33 Mn
Jun 30, 2025 -73.33 Mn
Mar 31, 2025 -87.02 Mn
Mar 31, 2025 -87.02 Mn
Dec 31, 2024 -9.56 Mn
Dec 31, 2024 -9.56 Mn
Sep 30, 2024 -72.20 Mn
Sep 30, 2024 -72.20 Mn
Jun 30, 2024 504.56 Mn
Jun 30, 2024 504.56 Mn
Mar 31, 2024 -69.01 Mn
Mar 31, 2024 -69.01 Mn
Dec 31, 2023 -46.95 Mn
Dec 31, 2023 -46.95 Mn