Bicycle Therapeutics (BCYC) EBITDA (2018 - 2026)

Bicycle Therapeutics posted quarterly EBITDA of -$62.6 million for Q1 2026, little changed year-on-year from -$62.9 million in Q1 2025, and down 210.08% on a QoQ basis from -$20.2 million in Q4 2025.

Bicycle Therapeutics (BCYC) has 9 years of EBITDA data on file, last reported at -$62.6 million in Q1 2026.

  • For the quarter ending Q1 2026, EBITDA changed 0.43% year-over-year to -$62.6 million; the trailing twelve-month figure through Mar 2026 stood at -$222.8 million (down 9.29% YoY), and the FY2025 full-year result was -$222.6 million, down 32.8% from the prior year.
  • EBITDA for Q1 2026 stood at -$62.6 million, down from -$20.2 million in the prior quarter.
  • Across five years, EBITDA topped out at -$20.2 million in Q4 2025 and bottomed at -$80.9 million in Q2 2025.
  • The 5-year median for EBITDA is -$43.6 million (2023), against an average of -$43.8 million.
  • Peak annual rise in EBITDA reached 58.42% in 2025, while the deepest fall reached 139.41% in 2025.
  • A 5-year view of EBITDA shows it stood at -$30.1 million in 2022, then slumped by 76.92% to -$53.3 million in 2023, then rose by 8.89% to -$48.6 million in 2024, then jumped by 58.42% to -$20.2 million in 2025, then slumped by 210.08% to -$62.6 million in 2026.
  • The last three EBITDA figures came in at -$62.6 million (Q1 2026), -$20.2 million (Q4 2025), and -$59.2 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBITDA (Qtr)
1 Quantum Biopharma 1,216,509.61 Bn 1,216,509.61 Bn - -13.63 Mn
2 Alterity Therapeutics 764,224.41 Bn 764,224.38 Bn - -
3 Legend Biotech 2,716.00 Bn 2,715.71 Bn 242.10 Mn -19.70 Mn
4 Nanobiotix 2,248.83 Bn 2,248.77 Bn - -
5 Akari Therapeutics 1,951.18 Bn 1,951.17 Bn - -14.44 Mn
6 Vertex Pharmaceuticals 113.69 Bn 106.44 Bn 2.59 Bn 1.14 Bn
7 Evaxion A 64.16 Bn 64.14 Bn - -3.82 Mn
8 Regeneron Pharmaceuticals 63.94 Bn 55.18 Bn 3.31 Bn 661.60 Mn
9 Alnylam Pharmaceuticals 40.13 Bn 37.12 Bn 959.66 Mn 201.19 Mn
10 Bicycle Therapeutics 326.82 Mn 326.82 Mn - -62.60 Mn

Historic Data

Download Data 🔒
DateValue
Mar 31, 2026 -62.60 Mn
Dec 31, 2025 -20.19 Mn
Sep 30, 2025 -59.21 Mn
Jun 30, 2025 -80.85 Mn
Mar 31, 2025 -62.33 Mn
Dec 31, 2024 -48.55 Mn
Sep 30, 2024 -52.90 Mn
Jun 30, 2024 -40.13 Mn
Mar 31, 2024 -26.04 Mn
Dec 31, 2023 -53.29 Mn
Sep 30, 2023 -46.14 Mn
Jun 30, 2023 -43.55 Mn
Mar 31, 2023 -39.38 Mn
Dec 31, 2022 -30.12 Mn
Sep 30, 2022 -27.45 Mn
Jun 30, 2022 -24.73 Mn
Mar 31, 2022 -26.64 Mn
Dec 31, 2021 -18.23 Mn
Sep 30, 2021 -14.37 Mn
Jun 30, 2021 -18.17 Mn
Mar 31, 2021 -16.25 Mn
Dec 31, 2020 -17.65 Mn
Sep 30, 2020 -9.40 Mn
Jun 30, 2020 -12.12 Mn
Mar 31, 2020 -13.51 Mn
Dec 31, 2019 -3.33 Mn
Sep 30, 2019 -9.91 Mn
Jun 30, 2019 -11.73 Mn
Mar 31, 2019 -5.42 Mn
Dec 31, 2018 -7.06 Mn
Sep 30, 2018 -8.23 Mn
Jun 30, 2018 -7.64 Mn
Mar 31, 2018 -2.93 Mn