Bicycle Therapeutics (BCYC) EBITDA (2018 - 2026)

Bicycle Therapeutics (BCYC) reported EBITDA of -$62.6 million for Q1 2026, little changed on a YoY basis from -$62.9 million in Q1 2025, and down 210.08% quarter-over-quarter from -$20.2 million in Q4 2025.

Bicycle Therapeutics (BCYC) EBITDA (2018 - 2026) Analysis & Trends

Bicycle Therapeutics has reported EBITDA for 9 years, with the latest figure at -$62.6 million in Q1 2026.

  • For the quarter ending Q1 2026, EBITDA changed 0.43% year-over-year to -$62.6 million; the trailing twelve-month figure through Mar 2026 stood at -$222.8 million (down 9.29% YoY), and the FY2025 full-year result was -$222.6 million, down 32.8% from the prior year.
  • EBITDA for Q1 2026 stood at -$62.6 million, down from -$20.2 million in the prior quarter.
  • The five-year high for EBITDA was -$20.2 million in Q4 2025, with the low at -$80.9 million in Q2 2025.
  • Historically, EBITDA has averaged -$43.8 million across 5 years, with a median of -$43.6 million in 2023.
  • The largest YoY upside for EBITDA was 58.42% in 2025 against a maximum downside of 139.41% in 2025.
  • Bicycle Therapeutics' EBITDA stood at -$30.1 million in 2022, then tumbled by 76.92% to -$53.3 million in 2023, then increased by 8.89% to -$48.6 million in 2024, then soared by 58.42% to -$20.2 million in 2025, then tumbled by 210.08% to -$62.6 million in 2026.
  • The last three EBITDA figures came in at -$62.6 million (Q1 2026), -$20.2 million (Q4 2025), and -$59.2 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBITDA (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -26.92 Mn
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -13.63 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -19.70 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -3.82 Mn
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -14.44 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -752,618.00
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.14 Bn
9 Abivax 91.96 Bn 91.96 Bn - -65.83 Mn
10 Bicycle Therapeutics 278.04 Mn 278.04 Mn - -62.60 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -62.60 Mn
Dec 31, 2025 -20.19 Mn
Sep 30, 2025 -59.21 Mn
Jun 30, 2025 -80.85 Mn
Mar 31, 2025 -62.33 Mn
Dec 31, 2024 -48.55 Mn
Sep 30, 2024 -52.90 Mn
Jun 30, 2024 -40.13 Mn
Mar 31, 2024 -26.04 Mn
Dec 31, 2023 -53.29 Mn
Sep 30, 2023 -46.14 Mn
Jun 30, 2023 -43.55 Mn
Mar 31, 2023 -39.38 Mn
Dec 31, 2022 -30.12 Mn
Sep 30, 2022 -27.45 Mn
Jun 30, 2022 -24.73 Mn
Mar 31, 2022 -26.64 Mn
Dec 31, 2021 -18.23 Mn
Sep 30, 2021 -14.37 Mn
Jun 30, 2021 -18.17 Mn