Annexon (ANNX) Return on Equity [ROE] (2020 - 2026)
Annexon's Return on Equity [ROE] was -107.81% in Q2 2026, down 17.00 percentage points from -90.81% a year earlier and down 9.27 percentage points from the prior quarter.
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Analysis
Annexon (ANNX) Return on Equity [ROE] (2020 - 2026) Analysis & Trends
For FY2025, Return on Equity [ROE] at Annexon came in at -85.75%, down 29.07 percentage points from FY2024.
- Return on Equity [ROE] shows a five-year change of -33.73 percentage points (FY2020 to FY2025).
- In earlier years, Return on Equity [ROE] was -56.68% in FY2024 (+2.99 pp), -59.67% in FY2023 (+3.21 pp), -62.88% in FY2022 (-17.51 pp) and -45.37% in FY2021 (+6.64 pp).
- Quarterly Return on Equity [ROE] has moved between -121.31% (Q3 2025) and -38.00% (Q3 2024) over five years.
- Compared with a year earlier, Return on Equity [ROE] has declined for six straight quarters, with an average year-over-year change of -24.15 percentage points over the last eight quarters.
- The best year-over-year quarter for Return on Equity [ROE] over five years was Q3 2024 (a gain of 50.07 percentage points); the worst was Q3 2025 (a drop of 83.30 percentage points).
- Per Business Quant data, ANNX's Return on Equity [ROE] in the three quarters before Q2 2026 was -98.54% (Q1 2026), -116.01% (Q4 2025) and -121.31% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROE (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 638.12 Bn | 556.64 Bn | 17.26 Bn | 25.32% |
| 2 | AbbVie | 462.60 Bn | 435.75 Bn | 12.70 Bn | - |
| 3 | Merck | 358.70 Bn | 313.13 Bn | 12.21 Bn | 7.21% |
| 4 | Novartis Ag | 272.16 Bn | 228.03 Bn | 11.24 Bn | 84.40% |
| 5 | Astrazeneca | 250.36 Bn | 223.92 Bn | 12.86 Bn | 21.39% |
| 6 | Amgen | 227.87 Bn | 183.27 Bn | 7.24 Bn | 83.75% |
| 7 | Gilead Sciences | 184.97 Bn | 159.08 Bn | 6.22 Bn | -18.38% |
| 8 | Pfizer | 162.61 Bn | 109.56 Bn | 10.94 Bn | 4.97% |
| 9 | Vertex Pharmaceuticals | 132.45 Bn | 104.46 Bn | 2.84 Bn | 22.24% |
| 10 | Annexon | 738.58 Mn | 738.58 Mn | - | -107.81% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -107.81% |
| Mar 31, 2026 | -98.54% |
| Dec 31, 2025 | -116.01% |
| Sep 30, 2025 | -121.31% |
| Jun 30, 2025 | -90.81% |
| Mar 31, 2025 | -68.13% |
| Dec 31, 2024 | -49.33% |
| Sep 30, 2024 | -38.00% |
| Jun 30, 2024 | -40.72% |
| Mar 31, 2024 | -51.10% |
| Dec 31, 2023 | -70.56% |
| Sep 30, 2023 | -88.07% |
| Jun 30, 2023 | -75.93% |
| Mar 31, 2023 | -67.89% |
| Dec 31, 2022 | -59.21% |
| Sep 30, 2022 | -68.29% |
| Jun 30, 2022 | -79.15% |
| Mar 31, 2022 | -64.63% |
| Dec 31, 2021 | -52.60% |
| Sep 30, 2021 | -41.55% |
API Access
Annexon Return on Equity [ROE] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=ANNX&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-equity-[roe]", "ticker": "ANNX", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=ANNX&period=max&api_key=YOUR_API_KEY");
const data = await res.json();